2-Iminobiotin  (Synonyms: Guanidinobiotin)

2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with K_is of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively^[1]. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage^[2].

Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

243.33

Solid

C₁₀H₁₇N₃O₂S

13395-35-2

[H][[email protected]](CS[[email protected]]1CCCCC(O)=O)([[email protected]]1([H])N2)NC2=N

Room temperature in continental US; may vary elsewhere.

• [1]. Sup SJ, et al. 2-Iminobiotin is an inhibitor of nitric oxide synthases. Biochem Biophys Res Commun. 1994 Oct 28;204(2):962-8.  [Content Brief]

  [2]. Zitta K, et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study. Front Pharmacol. 2018 Jan 11;8:971.  [Content Brief]