13395-35-2
Chemical Structure
2-Iminobiotin
Synonym(s): Guanidinobiotin
- CAS No.: 13395-35-2
- Formula:C10H17N3O2S
- Molecular Weight:243.33
IUPAC Name: 5-((3aS,4S,6aR)-2-iminohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid
InChIKey: WWVANQJRLPIHNS-ZKWXMUAHSA-N
SMILES: [H][C@](CS[C@H]1CCCCC(O)=O)([C@]1([H])N2)NC2=N
Biological Activity: 2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2].
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2-Iminobiotin | 99.95% | 2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage. | ||||||||||||||||||||
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- [1]. Sup SJ, et al. 2-Iminobiotin is an inhibitor of nitric oxide synthases. Biochem Biophys Res Commun. 1994 Oct 28;204(2):962-8. [Content Brief]
- [2]. Zitta K, et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study. Front Pharmacol. 2018 Jan 11;8:971. [Content Brief]
Keywords
