76985-52-9
Chemical Structure
2-Iminobiotin hydrobromide
Synonym(s): Guanidinobiotin hydrobromide
- CAS No.: 76985-52-9
- Formula:C10H18BrN3O2S
- Molecular Weight:324.24
IUPAC Name: 5-((3aS,4S,6aR)-2-iminohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid hydrobromide
InChIKey: JKIJLCYOCQWMQL-UFLZEWODSA-N
SMILES: [H][C@](CS[C@H]1CCCCC(O)=O)([C@]1([H])N2)NC2=N.Br
Biological Activity: 2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2].
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2-Iminobiotin hydrobromide | 98.0% | 2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage. | ||||||||||||||||||||
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2-Iminobiotin hydrobromide (Standard) | ≥98% | H-Gly-Gly-Gly-OH (Standard) is the analytical standard of H-Gly-Gly-Gly-OH. This product is intended for research and analytical applications. H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases. | ||||||||||||||||||||
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- [1]. Sup SJ, et al. 2-Iminobiotin is an inhibitor of nitric oxide synthases. Biochem Biophys Res Commun. 1994 Oct 28;204(2):962-8. [Content Brief]
- [2]. Zitta K, et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study. Front Pharmacol. 2018 Jan 11;8:971. [Content Brief]
