2. Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Tyrosinase SOD COX NO Synthase Keap1-Nrf2
  4. Mycosporine 2 glycine

Mycosporine 2 glycine is an anti-inflammatory agent and TYRP1 inhibitor. Mycosporine 2 glycine inhibits the expression of inflammatory genes and reduces nitric oxide production. Mycosporine 2 glycine binds tightly to the active pocket of TYRP1 and inhibits the activity of melanogenesis-related enzymes. Mycosporine 2 glycine can be used in the research of hyperpigmentation and inflammation-related diseases.

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Mycosporine 2 glycine

Mycosporine 2 glycine 화학구조

CAS No. : 149092-45-5

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Mycosporine 2 glycine Related Antibodies

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제품 설명

Mycosporine 2 glycine is an anti-inflammatory agent and TYRP1 inhibitor. Mycosporine 2 glycine inhibits the expression of inflammatory genes and reduces nitric oxide production. Mycosporine 2 glycine binds tightly to the active pocket of TYRP1 and inhibits the activity of melanogenesis-related enzymes. Mycosporine 2 glycine can be used in the research of hyperpigmentation and inflammation-related diseases[1][2].

In Vitro

Mycosporine 2 glycine (0.1-10 μM; 20 h) exhibits excellent biocompatibility with RAW 264.7 murine macrophages, with no decrease in cell viability[1].
Mycosporine 2 glycine (0.1-10 μM; 1 h pretreatment) potently inhibits LPS (HY-D1056)-induced NO production and the expression of key inflammatory genes iNOS and COX-2 in RAW 264.7 mouse macrophages[1].
Mycosporine 2 glycine (5-10 μM; 1 h pretreatment) inhibits the H2O2-induced upregulated expression of antioxidant genes Sod1, Cat and Nrf2, as well as the increased enzymatic activities of SOD and CAT, in RAW 264.7 mouse macrophages[1].
Mycosporine 2 glycine binds tightly to human TYRP1 with high binding affinity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mycosporine 2 glycine Related Antibodies

Cell Viability Assay[1]

Cell Line: RAW 264.7 murine macrophage cells
Concentration: 0.1, 1, 5, 10 μM
Incubation Time: 20 h
Result: Showed no reduction in cell viability, with viability values of 100.3%, 105.1%, 106.1%, and 110.1% relative to untreated controls (100%).
Significantly increased cell viability at 5 μM and 10 μM compared to controls.
Caused no visible morphological changes between untreated and treated cells.

RT-PCR[1]

Cell Line: H2O2-stressed RAW 264.7 murine macrophage cells
Concentration: 5, 10 μM
Incubation Time: 1 h pretreatment prior to H2O2 exposure
Result: Suppressed H2O2-induced upregulation of Sod1, Cat, and Nrf2 mRNA at both 5 μM and 10 μM, with significant reductions observed for all three genes.
분자량

302.28

화학식

C12H18N2O7
CAS No.
SMILES

COC1=C(NCC(O)=O)C[C@@](O)(CO)C/C1=N\CC(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
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Mycosporine 2 glycine Related Classifications

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Keywords:

Mycosporine 2 glycine149092-45-5TyrosinaseSODCOXNO SynthaseKeap1-Nrf2Superoxide DismutaseCyclooxygenaseNitric oxide synthasesNOSCOX-2NF-κB pathwaynitric oxideadvanced glycation end-productSod1RAW 264.7 murine macrophage cellsiNOSNrf2TYRP1CatInhibitorinhibitorinhibit

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Mycosporine 2 glycine
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