Mariaterpenoside A 

Mariaterpenoside A is an inducible nitric oxide synthase (iNOS) inhibitor. Mariaterpenoside A interacts with the active cavity of iNOS protein via hydrogen bonds with specific residues of the binding site. Mariaterpenoside A suppresses NO release in LPS (HY-D1056)-induced murine microglial BV-2 cells. Mariaterpenoside A can be used for the research of neurodegenerative disease^[1].

Mariaterpenoside A (Compound 3) potently inhibits LPS-induced NO production in murine microglial BV-2 cells with an IC₅₀ of 14.1 μM without significant cytotoxicity^[1].
Mariaterpenoside A interacts with the active cavity of iNOS protein (PDB code: 3E6T) with a binding energy of -8.28 kcal/mol, targeting residues GLY-365, TYR-367, GLU-371, PRO-344, and TRP-366^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

344.36

C₁₆H₂₄O₈

2097442-40-3

O[C@H]1[C@H](OC2=C(CO)C=CC(C(C)(C)O)=C2)O[C@H](CO)[C@@H](O)[C@@H]1O

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• [1]. Qin NB, et al. Bioactive terpenoids from Silybum marianum and their suppression on NO release in LPS-induced BV-2 cells and interaction with iNOS. Bioorg Med Chem Lett. 2017;27(10):2161-2165.  [Content Brief]