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Cat. No.: HY-N19854

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Mariaterpenoside A

Mariaterpenoside A is an inducible nitric oxide synthase (iNOS) inhibitor. Mariaterpenoside A interacts with the active cavity of iNOS protein via hydrogen bonds with specific residues of the binding site. Mariaterpenoside A suppresses NO release in LPS (HY-D1056)-induced murine microglial BV-2 cells. Mariaterpenoside A can be used for the research of neurodegenerative disease.

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CAS No.: 2097442-40-3
Formule: C₁₆H₂₄O₈
Masse moléculaire:344.36

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Mariaterpenoside A Chemical Structure

CAS No.: 2097442-40-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
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Bioz

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Description

IC₅₀ & Target^[1]

iNOS

Voir tous les produits spécifiques à Isoform NO Synthase :

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	14.1 μM Compound: 3	Inhibition of LPS-induced NO production in mouse BV2 cells after 20 hrs by Griess assay Inhibition of LPS-induced NO production in mouse BV2 cells after 20 hrs by Griess assay	[PMID: 28377060]

In Vitro

Mariaterpenoside A (Compound 3) potently inhibits LPS-induced NO production in murine microglial BV-2 cells with an IC₅₀ of 14.1 μM without significant cytotoxicity^[1].
Mariaterpenoside A interacts with the active cavity of iNOS protein (PDB code: 3E6T) with a binding energy of -8.28 kcal/mol, targeting residues GLY-365, TYR-367, GLU-371, PRO-344, and TRP-366^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2097442-40-3
Masse moléculaire 344.36
Formule C₁₆H₂₄O₈
SMILES

O[C@H]1[C@H](OC2=C(CO)C=CC(C(C)(C)O)=C2)O[C@H](CO)[C@@H](O)[C@@H]1O
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
- Plants
- Compositae
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Qin NB, et al. Bioactive terpenoids from Silybum marianum and their suppression on NO release in LPS-induced BV-2 cells and interaction with iNOS. Bioorg Med Chem Lett. 2017;27(10):2161-2165. [Content Brief]

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Mariaterpenoside A

Voir tous les produits spécifiques à Isoform NO Synthase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Mariaterpenoside A Related Classifications

HY-N19854 Related Classifications