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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
rat aldose reductase
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "rat aldose reductase" in MCE Product Catalog:
11
11 Publications Verification
Cat. No.: HY-N0033
CAS No.: 94079-81-9
Category:
Cardiovascular Disease Callicarpa formosana Rolfe Plants Simple Phenylpropanols Scrophulariaceae Extract Phenols Polyphenols Phenylpropanoids Verbenaceae Extract Disease Research Fields Inflammation/Immunology Brandisia hancei Hook. f.
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2
2 Cited Publications
Cat. No.: HY-N0311
CAS No.: 23313-21-5
Category:
Quinones Anthraquinones Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer
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1
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Ranirestat (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC50s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a Ki of 0.38 nM for recombinant human AR. Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment. Ranirestat also has a neuroprotective effect on diabetic retinas .
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Alrestatin (AY-22284) is an aldose reductase inhibitor. Alrestatin reduces fructose levels in the uterine fluid of mice. Alrestatin interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin can be used in studies related to diabetes and reproductive diseases .
Cat. No.: HY-119842
CAS No.: 97677-19-5
Synonyms: AL1567
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ALO1567 (AL1567) is an orally available aldose reductase inhibitor with an IC50 of 27 nM for rat lens aldose reductase. ALO1567 can be used in the research of diabetes .
Cat. No.: HY-N7962
CAS No.: 40661-45-8
Category:
Phyla nodiflora (L.) E. L. Greene Quinones Benzene Quinones Plants Verbenaceae Extract Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-N9335
CAS No.: 203734-35-4
Category:
Flavonoids Rhododendron dauricum Linn. Flavonones Phenols Polyphenols Ericaceae Extract Plants
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Cat. No.: HY-151946
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ALR2-IN-2 is a potent inhibitor of aldose reductase (ALR2), with IC50s of 27 nM and 228 nM for rat ALR2 and ALR1, respectively. ALR2-IN-2 can be used for the research of diabetic complications .
Cat. No.: HY-151947
CAS No.: 3062622-02-7
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ALR2-IN-2 is a potent inhibitor of aldose reductase (ALR2), with IC50s of 22 nM and 116 nM for rat ALR2 and ALR1, respectively. ALR2-IN-2 can be used for the research of diabetic complications .
Cat. No.: HY-N1517A
CAS No.: 98296-48-1
Category:
Terpenoids Polyporaceae Extract Ganoderma lucidum (Leyss. Ex Fr.) Karst. Diterpenoids Plants
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Cat. No.: HY-B1202A
CAS No.: 51876-97-2
Synonyms: AY-22284A
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Alrestatin (AY-22284) sodium is an aldose reductase inhibitor. Alrestatin sodium reduces fructose levels in the uterine fluid of mice. Alrestatin sodium interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin sodium decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin sodium enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin sodium can be used in studies related to diabetes and reproductive diseases .
Cat. No.: HY-N0033R
CAS No.: 94079-81-9
Category:
Simple Phenylpropanols Scrophulariaceae Extract Callicarpa formosana Rolfe Phenols Polyphenols Phenylpropanoids Plants Verbenaceae Extract Brandisia hancei Hook. f.
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Cat. No.: HY-101555
CAS No.: 128851-36-5
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M 16209 is an orally active aldose reductase (AR) inhibitor. M 16209 inhibits partially purified AR from various sources with IC50 values of 0.12, 0.24, 4.5, 1.2 and 9.3 μM for rat lens AR, bovine lens AR, bovine kidney AR, canine lens AR and human placental AR. M 16209 can be used for the research of metabolic disease, such as diabetes .
Cat. No.: HY-146329R
CAS No.: 2581109-51-3
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Ganoderic acid C2 (Standard) is the analytical standard of Ganoderic acid C2. This product is intended for research and analytical applications. Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 exhibits high inhibitory activity against the rat lens aldose reductase (RLAR) with an IC50 of 3.8 µM .
Cat. No.: HY-N3716
CAS No.: 517885-72-2
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Cat. No.: HY-B1202R
CAS No.: 51411-04-2
Synonyms: AY-22284 (Standard)
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Alrestatin (AY-22284) Standard is the analytical standard of Alrestatin (HY-B1202). This product is intended for research and analytical applications. Alrestatin (AY-22284) is an aldose reductase inhibitor. Alrestatin reduces fructose levels in the uterine fluid of mice. Alrestatin interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin can be used in studies related to diabetes and reproductive diseases.
Cat. No.: HY-N0311R
CAS No.: 23313-21-5
Cat. No.: HY-W151897
CAS No.: 309283-89-4
Synonyms: CMTI
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Cemtirestat (CMTI) is a carboxymethylated thiatriazinoindole inhibitor of aldose reductase (ALR2). Cemtirestat potently inhibits rat ocular lens ALR2 with an IC50 of 0.116 μM, and exhibits a 302-fold selectivity for rat kidney ALR1. Cemtirestat is applicable to the research of advanced diabetic complications .
Cat. No.: HY-119058
CAS No.: 463976-07-0
Synonyms: CP-744809
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ARI-809 (CP-744809) is a highly selective, orally active aldose reductase inhibitor with an IC50 of 1 nM. ARI-809 blocks excessive glucose flux through the polyol pathway. ARI-809 normalizes elevated sorbitol and fructose levels in sciatic nerve tissues of diabetic rat models, inhibits sorbitol accumulation in lens tissues, and brings elevated urinary albumin excretion close to normal. ARI-809 can be used in diabetes research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
