2. Metabolic Enzyme/Protease
  3. Aldose Reductase
  4. Alrestatin sodium

Alrestatin (AY-22284) sodium is an aldose reductase inhibitor. Alrestatin sodium reduces fructose levels in the uterine fluid of mice. Alrestatin sodium interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin sodium decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin sodium enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin sodium can be used in studies related to diabetes and reproductive diseases.

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Alrestatin sodium

Alrestatin sodium Chemical Structure

CAS No. : 51876-97-2

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Alrestatin sodium Related Antibodies

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Description

Alrestatin (AY-22284) sodium is an aldose reductase inhibitor. Alrestatin sodium reduces fructose levels in the uterine fluid of mice. Alrestatin sodium interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin sodium decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin sodium enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin sodium can be used in studies related to diabetes and reproductive diseases[1][2].

In Vitro

Alrestatin (1-5 mg/mL; 15 min) sodium dose-dependently inhibits basal and tyramine-stimulated 3H-norepinephrine release from rat splenic and pancreatic tissue samples in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alrestatin sodium Related Antibodies
In Vivo

Alrestatin (0.75 mmol/kg; intravenous injection; single bolus) sodium significantly enhances glucose-stimulated insulin secretion and improves glucose clearance in fasted, anesthetized non-diabetic male Sprague-Dawley rats, but exerts no effect on basal plasma glucose or insulin levels[1].
Alrestatin (0.15 μg/μL; intrauterine infusion) sodium significantly reduces fructose levels in mouse uterine fluid without altering glucose or sorbitol levels[2].
Alrestatin (1.5 mmol/L; intrauterine injection) sodium significantly reduces sperm capacitation rate and fertilization rate in mice, while co-administration of fructose or sorbitol reverses these effects[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 200-250 g, fasted, anaesthetized)[1]
Dosage: 0.75 mmol/kg
Administration: i.v.; single bolus
Result: Produced significantly greater mean incremental plasma insulin levels compared to vehicle.
Reduced mean incremental plasma glucose levels significantly compared to vehicle.
Did not significantly alter basal fasting plasma glucose or insulin levels relative to vehicle when administered without glucose.
Molecular Weight

277.21

Formula

C14H8NNaO4
CAS No.
SMILES

O=C([O-])CN(C(C1=CC=CC2=CC=CC3=C12)=O)C3=O.[Na+]
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Purity & Documentation
References
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Alrestatin sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alrestatin51876-97-2AY-22284AAldose Reductasepolyol pathwaymouse sperm capacitationrat pancreatic preparationsinsulinnorepinephrinemouse fertilizationmouse uterine fluiddiabetes mellitusaldose reductaselens aldose reductaseInhibitorinhibitorinhibit

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