Quercetin 3-gentiobioside
Based on 1 Customer Validation
Quercetin 3-gentiobioside is a flavonoid found in Artemisia iwayomogi. Quercetin 3-gentiobioside inhibits aromatase with an Ki of 46.77 nM. Quercetin 3-gentiobioside inhibits aldose reductase (AR) and the formation of advanced glycation end products (AGEs), with IC50 values of 10.60 μM and 109.46 μM, respectively. Quercetin 3-gentiobioside inhibits proliferation of cancer cells and fibroblast-like synoviocytes. Quercetin 3-gentiobioside can be used for the research of cancer, such as lung carcinoma.
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 7431-83-6
- Formula: C27H30O17
- Molecular Weight:626.52
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Quercetin 3-gentiobioside binds to human placental aromatase (PDB:3EQM) with a binding affinity of -10 kcal/mol and an estimated Ki of 46.77 nM, forming specific hydrogen and non-bonded interactions within the enzyme's binding pocket[1].
Quercetin 3-gentiobioside (25-100 μM; 48 h) significantly inhibits the proliferation of NCI-N87, A375, and A549 cells[2].
Quercetin 3-gentiobioside (50-300 μM; 48 h) significantly inhibits the proliferation of HFLS-RA cells, with a maximum inhibition rate of 42.99%[2].
Quercetin 3-gentiobioside inhibits aldose reductase (AR) and the formation of advanced glycation end products (AGEs), with IC50 values of 10.60 μM and 109.46 μM, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-N87 (gastric cancer), A375 (melanoma), A549 (type II epithelial lung carcinoma)
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Concentration:25 μM, 50 μM, 100 μM
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Incubation Time:48 h
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Result:Inhibited NCI-N87 cell proliferation by 42.45% (p < 0.05) at 100 μM.
Inhibited A375 cell proliferation by 75.99% (p < 0.05) at 100 μM.
Exhibited antiproliferative effects on A549 cells with no significant difference in activity across tested concentrations.
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Cell Line:HFLS-RA (fibroblast-like synoviocyte rheumatoid arthritis)
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Concentration:50 μM, 100 μM, 200 μM, 300 μM
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Incubation Time:48 h
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Result:Inhibited HFLS-RA cell proliferation by 42.99% at 300 μM.
Chemical Information
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CAS No. 7431-83-6
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Appearance Solid
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Molecular Weight 626.52
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Formula C27H30O17
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Color Light yellow to yellow
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SMILES
O=C1C(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)=C(C4=CC(O)=C(O)C=C4)OC5=CC(O)=CC(O)=C51
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (159.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.99 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.99 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Lee Y K, et al. Inhibitory effect of chemical constituents isolated from Artemisia iwayomogi on polyol pathway and simultaneous quantification of major bioactive compounds[J]. BioMed Research International, 2017, 2017(1): 7375615. [Content Brief]
[2]. Mallur DJ, et al. Exploring okra-derived compounds as prospective aromatase inhibitors: a computational study for enhanced breast cancer therapy. J Biomol Struct Dyn. 2025;43(17):9857-9865. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5961 mL | 7.9806 mL | 15.9612 mL | 39.9030 mL |
| 5 mM | 0.3192 mL | 1.5961 mL | 3.1922 mL | 7.9806 mL | |
| 10 mM | 0.1596 mL | 0.7981 mL | 1.5961 mL | 3.9903 mL | |
| 15 mM | 0.1064 mL | 0.5320 mL | 1.0641 mL | 2.6602 mL | |
| 20 mM | 0.0798 mL | 0.3990 mL | 0.7981 mL | 1.9951 mL | |
| 25 mM | 0.0638 mL | 0.3192 mL | 0.6384 mL | 1.5961 mL | |
| 30 mM | 0.0532 mL | 0.2660 mL | 0.5320 mL | 1.3301 mL | |
| 40 mM | 0.0399 mL | 0.1995 mL | 0.3990 mL | 0.9976 mL | |
| 50 mM | 0.0319 mL | 0.1596 mL | 0.3192 mL | 0.7981 mL | |
| 60 mM | 0.0266 mL | 0.1330 mL | 0.2660 mL | 0.6650 mL | |
| 80 mM | 0.0200 mL | 0.0998 mL | 0.1995 mL | 0.4988 mL | |
| 100 mM | 0.0160 mL | 0.0798 mL | 0.1596 mL | 0.3990 mL |
Quercetin 3-gentiobioside Related Classifications
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