1. Metabolic Enzyme/Protease
  2. Aldose Reductase
  3. Risarestat

Risarestat (Synonyms: CT 112)

Cat. No.: HY-16433 Purity: 98.09%
Handling Instructions

Risarestat (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications.

For research use only. We do not sell to patients.

Risarestat Chemical Structure

Risarestat Chemical Structure

CAS No. : 79714-31-1

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5 mg USD 500 In-stock
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Description

Risarestat (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications.

In Vivo

Risarestat inhibits the accumulation of dulcitol in a dose-dependent manner, except for the 1.0% solution which has an activity comparable to the 0.25% solution[1]. Risarestat peaks in the corneal epithelium, stroma, endothelium and aqueous humor in 30 minutes following instillation, then gradually diminishes time-dependently over a period of 24 hours. Risarestat remains detectable in the lens up to 24 hours, with a peak concentration at 2 hours after instillation[2]. The anterior surface area of superficial cells in the group treated with Risarestat is significantly decreases from a mean value of 881 to 728 microns2. Corneal sensitivity significantly improves from 5.36 to 1.37 g/mm2[3]. Animals treated with Risarestat shows a significant increase in the mean blinkresponse compared to untreated galactose-fed rats and does not differ significantly from controls towards the completion of the 7 month study. Animals treated topically with Risarestat and untreated galactose-fed rats develop bilateral nuclear cataracts within 3 weeks[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

323.41

Formula

C₁₆H₂₁NO₄S

CAS No.
SMILES

O=C(N1)SC(C2=CC=C(OCCCCC)C(OCC)=C2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 105 mg/mL (324.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0921 mL 15.4603 mL 30.9205 mL
5 mM 0.6184 mL 3.0921 mL 6.1841 mL
10 mM 0.3092 mL 1.5460 mL 3.0921 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5.25 mg/mL (16.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1][2]

Rats: The other 5 groups are fed on a 50% galactose diet, and 0.1, 0.25, 0.5 or 1.0% Risarestat ophthalmic solution or its vehicle is instilled in both eyes 4 times a day in each of the 5 treated groups. After 2 weeks, the corneal epithelium is scraped off in all rats and its dulcitol content is determined by gas chromatography[1].

Rabbits: Risarestat is prepared in acetate-buffered saline. 50 μL of 0.5% Risarestat in 7mM acetate-buffered saline (pH 5.2, 290 mOsm) containing 0.15% chlorbutanol as a preservative is instilled to both conjunctival sac of rabbits. This ophthalmic solution is proven to be untoxic to the external eye after 90 days' instillation to the rabbits 9 times a day. The rabbits are then sacrificed at, 15 and 30 minutes, 1, 2, 4, 8, and 24 hours after instillation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

RisarestatCT 112CT112CT-112Aldose ReductaseInhibitorinhibitorinhibit

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Risarestat
Cat. No.:
HY-16433
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