1. Metabolic Enzyme/Protease
  2. Aldose Reductase
  3. Epalrestat

Epalrestat (Synonyms: ONO2235)

Cat. No.: HY-66009 Purity: >98.0%
Handling Instructions

Epalrestat is an aldose reductase inhibitor for the treatment of diabetic neuropathy.

For research use only. We do not sell to patients.

Epalrestat Chemical Structure

Epalrestat Chemical Structure

CAS No. : 82159-09-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 160 In-stock
Estimated Time of Arrival: December 31
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Description

Epalrestat is an aldose reductase inhibitor for the treatment of diabetic neuropathy. Target: Aldose Reductase Epalrestat may affect or delay progression of the underlying disease process. Data from six clinical trials were evaluated, and it was determined that epalrestat 50 mg 3 times/day may improve motor and sensory nerve conduction velocity and subjective neuropathy symptoms as compared with baseline and placebo. Epalrestat may serve as a new therapeutic option to prevent or slow the progression of diabetic neuropathy [1]. Epalrestat significantly increased the amplitude of 3 cpm waves on EGG and improved the spectral analytical parameters of heart rate variability. These findings suggest that epalrestat is useful for the treatment of diabetic gastroparesis [2]. Epalrestat is a highly effective and safe agent for the treatment of diabetic neuropathy [3].

Clinical Trial
Molecular Weight

319.40

Formula

C₁₅H₁₃NO₃S₂

CAS No.

82159-09-9

SMILES

O=C(O)CN(C/1=O)C(SC1=C/C(C)=C/C2=CC=CC=C2)=S

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 3.2 mg/mL (10.02 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1309 mL 15.6544 mL 31.3087 mL
5 mM 0.6262 mL 3.1309 mL 6.2617 mL
10 mM 0.3131 mL 1.5654 mL 3.1309 mL
*Please refer to the solubility information to select the appropriate solvent.
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Epalrestat
Cat. No.:
HY-66009
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