1. Metabolic Enzyme/Protease
  2. Aldose Reductase
  3. Fidarestat

Fidarestat (Synonyms: SNK 860)

Cat. No.: HY-105185
Handling Instructions

Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.

For research use only. We do not sell to patients.

Fidarestat Chemical Structure

Fidarestat Chemical Structure

CAS No. : 136087-85-9

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Description

Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.

IC50 & Target

IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10)[1]

In Vitro

Fidarestat is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively[1].

In Vivo

Fidarestat (SNK-860; 1 or 4 mg/kg. p.o., daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats[2].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

279.22

Formula

C₁₂H₁₀FN₃O₄

CAS No.

136087-85-9

SMILES

O=C1NC(N[[email protected]@]12C3=C(C=CC(F)=C3)O[[email protected]](C(N)=O)C2)=O

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Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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Fidarestat

Cat. No.: HY-105185