82159-09-9
82159-09-9
Chemical Structure
Epalrestat
Synonym(s): ONO2235
- CAS. Nr.: 82159-09-9
- Formula:C15H13NO3S2
- Molecular Weight:319.40
IUPAC Name: 2-((Z)-5-((E)-2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid
InChIKey: CHNUOJQWGUIOLD-NFZZJPOKSA-N
SMILES: O=C(O)CN(C/1=O)C(SC1=C/C(C)=C/C2=CC=CC=C2)=S
Biological Activity: Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy[1][2][3].
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Epalrestat | 99.62% | Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy. | ||||||||||||||||||||
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Epalrestat (Standard) | 98.59% | Epalrestat (Standard) is the analytical standard of Epalrestat. This product is intended for research and analytical applications. Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy. | ||||||||||||||||||||
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Epalrestat-d5 | Epalrestat-d5 is deuterium labeled Epalrestat. Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy. | |||||||||||||||||||||
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References
- [1]. Ramirez, M.A. and N.L. Borja, Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy. Pharmacotherapy, 2008. 28(5): p. 646-55. [Content Brief]
- [2]. Okamoto, H., et al., Effects of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy and gastroparesis. Intern Med, 2003. 42(8): p. 655-64. [Content Brief]
- [3]. Hotta, N., et al., Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: multicenter study. Diabetic Neuropathy Study Group in Japan. J Diabetes Complications, 1996. 10(3): p. 168-72. [Content Brief]
