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PFM01 

Cat. No.: HY-116770
Handling Instructions

PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor.

For research use only. We do not sell to patients.

PFM01 Chemical Structure

PFM01 Chemical Structure

CAS No. : 1558598-41-6

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Description

PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor[1][2].

IC50 & Target

Endonuclease[1]

In Vitro

PFM01 (100 μM) rescues the repair defect in 48BR (WT) and HSC62 (BRCA2-defective) primary cells[1].
PFM01 (100 μM) diminishes the RAD51 foci formation in 1BR3 (WT) and HSC62 (BRCA2-defective) cells[1].
PFM01 (100 μM) enhances non-homologous end-joining (NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells[1].
PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells[1].

Molecular Weight

293.40

Formula

C₁₄H₁₅NO₂S₂

CAS No.

1558598-41-6

SMILES

O=C1N(CC(C)C)C(S/C1=C\C2=CC=C(O)C=C2)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PFM01PFM 01PFM-01OthersN-alkylatedMirinderivativeMRE11endonucleaseNHEJDSBInhibitorinhibitorinhibit

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