1. Metabolic Enzyme/Protease
  2. Aldose Reductase
  3. Sorbinil

Sorbinil 

Cat. No.: HY-50289 Purity: 99.12%
COA Handling Instructions

Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.

For research use only. We do not sell to patients.

Sorbinil Chemical Structure

Sorbinil Chemical Structure

CAS No. : 68367-52-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 143 In-stock
Solution
10 mM * 1 mL in DMSO USD 143 In-stock
Solid
1 mg USD 50 In-stock
5 mg USD 130 In-stock
10 mg USD 210 In-stock
25 mg USD 420 In-stock
50 mg USD 670 In-stock
100 mg USD 1070 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.

In Vitro

Sorbinil (10 μM; 24 h) results an aldose reductase inhibition and attenuates LPS-induced oxidative stress/ROS production in Raw264.7 murine macrophages[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sorbinil (10 mg/kg; ip; single dose ) attenuates LPS-induced uveitis in mice eyes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

236.20

Formula

C11H9FN2O3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@]12C3=CC(F)=CC=C3OCC1)NC(N2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (423.37 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2337 mL 21.1685 mL 42.3370 mL
5 mM 0.8467 mL 4.2337 mL 8.4674 mL
10 mM 0.4234 mL 2.1169 mL 4.2337 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.85%

References
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Sorbinil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Sorbinil
Cat. No.:
HY-50289
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