2. Metabolic Enzyme/Protease
  3. Aldose Reductase
  4. Sorbinil

Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.

For research use only. We do not sell to patients.

Sorbinil Chemical Structure

Sorbinil Chemical Structure

CAS No. : 68367-52-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 143 In-stock
Solution
10 mM * 1 mL in DMSO USD 143 In-stock
Solid
1 mg USD 50 In-stock
5 mg USD 130 In-stock
10 mg USD 210 In-stock
25 mg USD 420 In-stock
50 mg USD 670 In-stock
100 mg USD 1070 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Sorbinil Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sorbinil

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.

In Vitro

Sorbinil (10 μM; 24 h) results an aldose reductase inhibition and attenuates LPS-induced oxidative stress/ROS production in Raw264.7 murine macrophages[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sorbinil Related Antibodies
In Vivo

Sorbinil (10 mg/kg; ip; single dose ) attenuates LPS-induced uveitis in mice eyes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

236.20

Formula

C11H9FN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@]12C3=CC(F)=CC=C3OCC1)NC(N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (423.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2337 mL 21.1685 mL 42.3370 mL
5 mM 0.8467 mL 4.2337 mL 8.4674 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.85%

COA (255 KB) LCMS (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2337 mL 21.1685 mL 42.3370 mL 105.8425 mL
5 mM 0.8467 mL 4.2337 mL 8.4674 mL 21.1685 mL
10 mM 0.4234 mL 2.1169 mL 4.2337 mL 10.5843 mL
15 mM 0.2822 mL 1.4112 mL 2.8225 mL 7.0562 mL
20 mM 0.2117 mL 1.0584 mL 2.1169 mL 5.2921 mL
25 mM 0.1693 mL 0.8467 mL 1.6935 mL 4.2337 mL
30 mM 0.1411 mL 0.7056 mL 1.4112 mL 3.5281 mL
40 mM 0.1058 mL 0.5292 mL 1.0584 mL 2.6461 mL
50 mM 0.0847 mL 0.4234 mL 0.8467 mL 2.1169 mL
60 mM 0.0706 mL 0.3528 mL 0.7056 mL 1.7640 mL
80 mM 0.0529 mL 0.2646 mL 0.5292 mL 1.3230 mL
100 mM 0.0423 mL 0.2117 mL 0.4234 mL 1.0584 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Sorbinil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sorbinil68367-52-2Aldose ReductaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Sorbinil
Cat. No.:
HY-50289
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.