Sorbinil
Based on 2 publication(s) in Google Scholar
Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.08%
- CAS 番号: 68367-52-2
- 分子式: C11H9FN2O3
- 分子量:236.20
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Anti-diabetic Compound Library
HY-L040
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Glucose Metabolism Compound Library
HY-L092
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Human Metabolite Library
HY-L123
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HY-L146
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Clinical Compound Library
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Drug Repurposing Compound Library
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MedChemExpress（MCE）の使用を引用している文献 Sorbinil
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生物活性
Sorbinil (10 μM; 24 h) results an aldose reductase inhibition and attenuates LPS-induced oxidative stress/ROS production in Raw264.7 murine macrophages[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 68367-52-2
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性状 Solid
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分子量 236.20
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分子式 C11H9FN2O3
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Color White to off-white
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SMILES
O=C([C@@]12C3=CC(F)=CC=C3OCC1)NC(N2)=O
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別名
ソルビニール
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Regen Biomater
Fabrication of a 3D bioprinting model for posterior capsule opacification using GelMA and PLMA hydrogel-coated resin. [Abstract]2024 Mar 1:11:rbae020. PMID: 38529352 -
溶剤 & 溶解度
DMSO : 100 mg/mL (423.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Huang Q, et al. Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications. Med Chem. 2019;15(1):3-7. [Content Brief]
[2]. Chang KC, et al. Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues. Chem Biol Interact. 2013 Feb 25;202(1-3):283-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2337 mL | 21.1685 mL | 42.3370 mL | 105.8425 mL |
| 5 mM | 0.8467 mL | 4.2337 mL | 8.4674 mL | 21.1685 mL | |
| 10 mM | 0.4234 mL | 2.1169 mL | 4.2337 mL | 10.5843 mL | |
| 15 mM | 0.2822 mL | 1.4112 mL | 2.8225 mL | 7.0562 mL | |
| 20 mM | 0.2117 mL | 1.0584 mL | 2.1169 mL | 5.2921 mL | |
| 25 mM | 0.1693 mL | 0.8467 mL | 1.6935 mL | 4.2337 mL | |
| 30 mM | 0.1411 mL | 0.7056 mL | 1.4112 mL | 3.5281 mL | |
| 40 mM | 0.1058 mL | 0.5292 mL | 1.0584 mL | 2.6461 mL | |
| 50 mM | 0.0847 mL | 0.4234 mL | 0.8467 mL | 2.1169 mL | |
| 60 mM | 0.0706 mL | 0.3528 mL | 0.7056 mL | 1.7640 mL | |
| 80 mM | 0.0529 mL | 0.2646 mL | 0.5292 mL | 1.3230 mL | |
| 100 mM | 0.0423 mL | 0.2117 mL | 0.4234 mL | 1.0584 mL |
Sorbinil 関連分類
HY-50289 関連分類
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