51876-97-2
Chemical Structure
Alrestatin sodium
Synonym(s): AY-22284A
- No. CAS: 51876-97-2
- Formula:C14H8NNaO4
- Molecular Weight:277.21
IUPAC Name: sodium 2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetate
InChIKey: FKZUETPACPDEAD-UHFFFAOYSA-M
SMILES: O=C([O-])CN(C(C1=CC=CC2=CC=CC3=C12)=O)C3=O.[Na+]
Biological Activity: Alrestatin (AY-22284) sodium is an aldose reductase inhibitor. Alrestatin sodium reduces fructose levels in the uterine fluid of mice. Alrestatin sodium interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin sodium decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin sodium enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin sodium can be used in studies related to diabetes and reproductive diseases[1][2].
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Alrestatin sodium | Alrestatin (AY-22284) sodium is an aldose reductase inhibitor. Alrestatin sodium reduces fructose levels in the uterine fluid of mice. Alrestatin sodium interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin sodium decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin sodium enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin sodium can be used in studies related to diabetes and reproductive diseases. | |||||||||||||||||||||
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- [1]. Kobric M, et al. Effect of alrestatin sodium on glucose-stimulated insulin secretion in the fasted anaesthetized rat. Horm Metab Res. 1978;10(6):495-500. [Content Brief]
- [2]. Lei Y, et al. Expression of aldose reductase in mouse endometrial epithelial cells and its role in sperm capacitation. Theriogenology. 2023;209:243-250. [Content Brief]
Keywords
