2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Cytochrome P450 DNA/RNA Synthesis
  4. β-​Apo-​8'-​carotenal

β-​Apo-​8'-​carotenal  (Synonyms: Apocarotenal)

Art. -Nr.: HY-N6677 Reinheit: 96.24%
COA
SDS
Handling Instructions Technical Support

β-Apo-8'-carotenal (Apocarotenal), an orally active provitamin A carotenoid. β-Apo-8'-carotenal can induce the expression of CYP1A through the Ah receptor-dependent pathway. β-Apo-8'-carotenal can induce cancer cells DNA strand breaks and lipid peroxidation. β-Apo-8'-carotenal can be used for the researches of cancer and metabolic disease.

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β-​Apo-​8'-​carotenal

β-​Apo-​8'-​carotenal Chemische Struktur

CAS. Nr. : 1107-26-2

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β-​Apo-​8'-​carotenal Related Antibodies

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Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen:

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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Beschreibung

β-Apo-8'-carotenal (Apocarotenal), an orally active provitamin A carotenoid. β-Apo-8'-carotenal can induce the expression of CYP1A through the Ah receptor-dependent pathway. β-Apo-8'-carotenal can induce cancer cells DNA strand breaks and lipid peroxidation. β-Apo-8'-carotenal can be used for the researches of cancer and metabolic disease[1][2][3].

IC50 & Target[1]

CYP1A1

 

CYP1A2

 

In Vitro

β-Apo-8'-carotenal (2-20 μM, retreated for 1 h) induces DNA strand breaks and lipid peroxidation and upregulates CYP1A2 protein expression in human lung adenocarcinoma A549 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-​Apo-​8'-​carotenal Related Antibodies
In Vivo

β-Apo-8'-carotenal (300 mg/kg free diet; 15 days) induces hepatic CYP1A1 and CYP1A2 expression in Wistar rats[1].
β-Apo-8'-carotenal (300 mg/kg free diet; 14 days) induces CYP1A2 protein expression and has no inductive effect on CYP1A1 in male Ah receptor-responsive C57BL/6 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molekulargewicht

416.64

Formel

C30H40O
CAS. Nr.
Appearance

Solid

Color

Dark blue to black

SMILES

O=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C
Structure Classification
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 1 mg/mL (2.40 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4002 mL 12.0008 mL 24.0015 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  Corn Oil

    Solubility: 4.17 mg/mL (10.01 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 96.24%

SDS (393 KB)

COA (241 KB) HNMR (283 KB) LCMS (111 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4002 mL 12.0008 mL 24.0015 mL 60.0038 mL
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β-​Apo-​8'-​carotenal Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-​Apo-​8'-​carotenal1107-26-2ApocarotenalCytochrome P450DNA/RNA SynthesisCYPsprovitaminAcarotenoidInhibitorinhibitorinhibit

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