Alitretinoin (Synonyms: 9-cis-Retinoic acid; 9-cis-レチノイン酸)

Name: 9-cis-Retinoic acid
Brand: MedChemExpress
SKU: HY-15128
Rating: 5.0 (5 reviews)

製品番号: HY-15128 純度: 99.92%: Data Sheet SDS COA 取扱説明書
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9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities.

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CAS 番号 : 5300-03-8

容量	価格（税別）	在庫状況	数量
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
5 mg	$150	在庫あり	Estimated Time of Arrival: December 31
10 mg	$250	在庫あり	Estimated Time of Arrival: December 31
25 mg	$480	在庫あり	Estimated Time of Arrival: December 31
50 mg	$750	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1200	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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カスタマーレビュー

Based on 5 publication(s) in Google Scholar

Other Forms of 9-cis-Retinoic acid:

9-cis-Retinoic acid-d₅ 在庫あり
9-cis-Retinoic acid (Standard) お問い合わせ

顧客検証

Others

Cell Imaging/Staining

: 9-cis-Retinoic acid purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 29;302(3):111211. [Abstract]; MutuDC1940 cells were treated for 20 h with 1 μM 9-cis-Retinoic acid (9cRA), then subjected to Western blotting.

: 9-cis-Retinoic acid purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 29;302(3):111211. [Abstract]; MutuDC1940 cells were treated for 20 h with 1 μM 9-cis-Retinoic acid (9cRA), then assayed for RALDH activity in the suspension cell format, utilising the indicated RAL concentrations for 20 min.

: 9-cis-Retinoic acid purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 29;302(3):111211. [Abstract]; mutuDC1940 cells were treated with 1 μM 9-cis-Retinoic acid (9cRA) for 20 hours (with or without), and then AldeRed retention assays were performed with or without 1 μM Win446 or 10 μM DEAB.

RAR/RXR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

RXRα RXRβ RXRγ

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

生物活性
純度とドキュメンテーション
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製品説明

IC₅₀ & Target

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
CV-1	EC₅₀	1.5 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha	[PMID: 11428923]
CV-1	EC₅₀	0.2 3 Compound: 36, 9cRA	Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at after 6 hrs by Dual-light chemiluminescent assay Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at after 6 hrs by Dual-light chemiluminescent assay	[PMID: 19216008]
HL-60	EC₅₀	2 1 Compound: 9-cis-RA	Induction of transglutaminase (TGase) activity in HL-60 cells Induction of transglutaminase (TGase) activity in HL-60 cells	[PMID: 8784454]
CV-1	EC₅₀	140 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay	10.1016/0960-894X(95)00588-K
HL-60	EC₅₀	2 1 Compound: 9-cis RA	Transglutaminase activity in HL-60 cdm-1 cells Transglutaminase activity in HL-60 cdm-1 cells	[PMID: 7636843]
CV-1	EC₅₀	191 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	3 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR beta Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR beta	[PMID: 11428923]
CV-1	EC₅₀	200 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	4 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR gamma Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR gamma	[PMID: 11428923]
CV-1	EC₅₀	250 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	0.2 3 Compound: 36, 9cRA	Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at after 6 hrs by Dual-light chemiluminescent assay Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at after 6 hrs by Dual-light chemiluminescent assay	[PMID: 19216008]
CV-1	EC₅₀	45 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	4.5 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gamma Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gamma	[PMID: 11428923]
CV-1	EC₅₀	50 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay	10.1016/0960-894X(95)00588-K
HEK293	EC₅₀	10 1 Compound: 9CisRA	Agonist activity at human RXRalpha expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at human RXRalpha expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 25305688]
HEK293	EC₅₀	10 1 Compound: 9CisRA	Agonist activity at human RXRalpha expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at human RXRalpha expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 25305688]
HEK293	EC₅₀	120 1 Compound: 9cRA	Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay	[PMID: 24801499]
HEK-293T	EC₅₀	1.09 3 Compound: 13	Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay	[PMID: 28169169]
HEK-293T	EC₅₀	1.09 3 Compound: 13	Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay	[PMID: 28169169]
HEK-293T	EC₅₀	1.73 3 Compound: 13	Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay	[PMID: 28169169]
CV-1	EC₅₀	0.2 3 Compound: 36, 9cRA	Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at after 6 hrs by Dual-light chemiluminescent assay Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at after 6 hrs by Dual-light chemiluminescent assay	[PMID: 19216008]
HEK-293T	EC₅₀	1.73 3 Compound: 13	Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay	[PMID: 28169169]
CV-1	EC₅₀	21 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR alpha Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR alpha	[PMID: 11428923]
CV-1	EC₅₀	1.5 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha	[PMID: 11428923]
CV-1	EC₅₀	29 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR beta Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR beta	[PMID: 12482435]
CV-1	EC₅₀	29 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR beta Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR beta	[PMID: 11428923]
CV-1	EC₅₀	100 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid X alpha receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid X alpha receptors co-transfected into CV-1 cells	[PMID: 8308867]
CV-1	EC₅₀	124 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing mouse Retinoid X receptor RXR gamma Transcriptional activation in CV-1 cells expressing mouse Retinoid X receptor RXR gamma	[PMID: 12482435]
CV-1	EC₅₀	45 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells	[PMID: 8308867]
CV-1	EC₅₀	128 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing mouse Retinoid X receptor RXR beta Transcriptional activation in CV-1 cells expressing mouse Retinoid X receptor RXR beta	[PMID: 12482435]
CV-1	EC₅₀	45 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	140 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	50 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid beta receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid beta receptors co-transfected into CV-1 cells	[PMID: 8308867]
CV-1	EC₅₀	140 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid X gamma receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid X gamma receptors co-transfected into CV-1 cells	[PMID: 8308867]
CV-1	EC₅₀	50 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	50 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR gamma Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR gamma	[PMID: 12482435]
CV-1	EC₅₀	191 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	191 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid alpha receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid alpha receptors co-transfected into CV-1 cells	[PMID: 8308867]
CV-1	EC₅₀	52 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta	[PMID: 8709094]
CV-1	EC₅₀	195 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing human Retinoid X receptor RXR-alpha Transcriptional activation in CV-1 cells expressing human Retinoid X receptor RXR-alpha	[PMID: 12482435]
CV-1	EC₅₀	74 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma	[PMID: 8709094]
CV-1	EC₅₀	200 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	100 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid X alpha receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid X alpha receptors co-transfected into CV-1 cells	[PMID: 8308867]
CV-1	EC₅₀	200 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid X beta receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid X beta receptors co-transfected into CV-1 cells	[PMID: 8308867]
HEK293	EC₅₀	120 1 Compound: 9cRA	Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay	[PMID: 24801499]
CV-1	EC₅₀	124 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing mouse Retinoid X receptor RXR gamma Transcriptional activation in CV-1 cells expressing mouse Retinoid X receptor RXR gamma	[PMID: 12482435]
CV-1	EC₅₀	200 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta	[PMID: 8709094]
CV-1	EC₅₀	21 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR alpha Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR alpha	[PMID: 11428923]
CV-1	EC₅₀	128 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing mouse Retinoid X receptor RXR beta Transcriptional activation in CV-1 cells expressing mouse Retinoid X receptor RXR beta	[PMID: 12482435]
CV-1	EC₅₀	219 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma	[PMID: 8709094]
CV-1	EC₅₀	140 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid X gamma receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid X gamma receptors co-transfected into CV-1 cells	[PMID: 8308867]
CV-1	EC₅₀	220 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR alpha Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR alpha	[PMID: 12482435]
CV-1	EC₅₀	140 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	250 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	191 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid alpha receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid alpha receptors co-transfected into CV-1 cells	[PMID: 8308867]
CV-1	EC₅₀	29 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR beta Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR beta	[PMID: 11428923]
CV-1	EC₅₀	191 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	29 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR beta Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR beta	[PMID: 12482435]
CV-1	EC₅₀	195 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing human Retinoid X receptor RXR-alpha Transcriptional activation in CV-1 cells expressing human Retinoid X receptor RXR-alpha	[PMID: 12482435]
CV-1	EC₅₀	3 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR beta Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR beta	[PMID: 11428923]
CV-1	EC₅₀	200 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid X beta receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid X beta receptors co-transfected into CV-1 cells	[PMID: 8308867]
CV-1	EC₅₀	304 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha	[PMID: 8709094]
CV-1	EC₅₀	200 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	316 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha	[PMID: 8709094]
CV-1	EC₅₀	200 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta	[PMID: 8709094]
CV-1	EC₅₀	219 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma	[PMID: 8709094]
CV-1	EC₅₀	4 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR gamma Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR gamma	[PMID: 11428923]
CV-1	EC₅₀	4.5 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gamma Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gamma	[PMID: 11428923]
CV-1	EC₅₀	220 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR alpha Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR alpha	[PMID: 12482435]
CV-1	EC₅₀	45 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	250 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	304 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha	[PMID: 8709094]
CV-1	EC₅₀	45 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells	[PMID: 8308867]
CV-1	EC₅₀	316 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha	[PMID: 8709094]
CV-1	EC₅₀	50 1 Compound: 9-cis RA	Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR gamma Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR gamma	[PMID: 12482435]
CV-1	EC₅₀	50 1 Compound: 9-cis-RA	Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay	10.1016/0960-894X(95)00588-K
CV-1	EC₅₀	50 1 Compound: 9-cis-RA	Binding affinity against retinoic Acid beta receptors co-transfected into CV-1 cells Binding affinity against retinoic Acid beta receptors co-transfected into CV-1 cells	[PMID: 8308867]
CV-1	EC₅₀	52 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta	[PMID: 8709094]
CV-1	EC₅₀	74 1 Compound: 9-cis-RA	Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma	[PMID: 8709094]
HEK-293T	EC₅₀	1.09 3 Compound: 13	Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay	[PMID: 28169169]
HEK-293T	EC₅₀	1.73 3 Compound: 13	Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay	[PMID: 28169169]
HEK293	EC₅₀	10 1 Compound: 9CisRA	Agonist activity at human RXRalpha expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at human RXRalpha expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 25305688]
HEK293	EC₅₀	120 1 Compound: 9cRA	Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay	[PMID: 24801499]
HL-60	EC₅₀	2 1 Compound: 9-cis RA	Transglutaminase activity in HL-60 cdm-1 cells Transglutaminase activity in HL-60 cdm-1 cells	[PMID: 7636843]
HL-60	EC₅₀	2 1 Compound: 9-cis-RA	Induction of transglutaminase (TGase) activity in HL-60 cells Induction of transglutaminase (TGase) activity in HL-60 cells	[PMID: 8784454]

体外実験

9-cis-Retinoic acid (1-10 μM; 0-5 days; CA 9-22 and NA cells) treatment significantly decreases proliferation in a dose-dependent manner in CA 9-22 and NA cells^[1].
9-cis-Retinoic acid (1 μM; 24 hours) treatment significantly increases PPARγ functional activity by >200% in CA 9-22 and NA aerodigestive cells^[1].
9-cis-Retinoic acid treatment results in the formation of a nuclear PPARγ-RXRα heterodimer supershift complex in CA 9-22 cells^[1].
9-cis-Retinoic acid inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma (CTCL) in a dose-dependent and time-dependent manner. 9-cis-Retinoic acid also induces G0/G1 cell cycle arrest by downregulation of cyclin D1. 9-cis-Retinoic acid significantly decreases phosphorylation of JAK1, STAT3, and STAT5 and downregulated Bcl-xL and cyclin D1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	CA 9-22 and NA cells
Concentration:	1 μM, 10 μM
Incubation Time:	0 day, 1 day, 3 days, 5 days
Result:	Significantly decreased proliferation.

体内実験

9-cis-Retinoic acid (1 mg/kg; intravenous injection; daily; for 10 days; male C57BL/6J mice) treatment significantly decreases the serum ALT and AST level, alleviates hepatic necrosis of the bile duct ligation (BDL)-mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6J mice (6-8 weeks; 19-22 g) treatment with bile duct ligated^[3]
Dosage:	1 mg/kg
Administration:	Intravenous injection; daily; for 10 days
Result:	Significantly decreased the serum ALT and AST level, alleviated hepatic necrosis.

臨床実験

分子量

300.44

分子式

C₂₀H₂₈O₂

CAS 番号

5300-03-8

Appearance

Solid

Color

White to yellow

SMILES

CC(/C=C/C(C(C)(CCC1)C)=C1C)=C/C=C/C(C)=C/C(O)=O

Structure Classification

Initial Source

Endogenous metabolite

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (83.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3285 mL	16.6423 mL	33.2845 mL
5 mM	0.6657 mL	3.3285 mL	6.6569 mL
10 mM	0.3328 mL	1.6642 mL	3.3285 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (8.32 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (8.32 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.92%

Select Batch:

データシート (278 KB) SDS (557 KB)

COA (247 KB) HNMR (254 KB) RP-HPLC (248 KB) LCMS (107 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Raul Rosas, et al. Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells. Anticancer Res. 2020 Jun;40(6):3071-3080. [Content Brief]

[2]. Hua Yang, et al. Effects of 9-cis-retinoic Acid on the Proliferation and Apoptosis of Cutaneous T-cell Lymphoma Cells. Anticancer Drugs. 2019 Jan;30(1):56-64. [Content Brief]

[3]. Zhiqing Yuan, et al. 9-cis-retinoic Acid Elevates MRP3 Expression by Inhibiting Sumoylation of RXRα to Alleviate Cholestatic Liver Injury. Biochem Biophys Res Commun. 2018 Sep 3;503(1):188-194. [Content Brief]

[4]. V M Manzano, et al. Human Renal Mesangial Cells Are a Target for the Anti-Inflammatory Action of 9-cis Retinoic Acid. Br J Pharmacol. 2000 Dec;131(8):1673-83. [Content Brief]

[5]. Gro H Mathisen, et al. Delayed Translocation of NGFI-B/RXR in Glutamate Stimulated Neurons Allows Late Protection by 9-cis Retinoic Acid. Biochem Biophys Res Commun. 2011 Oct 14;414(1):90-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3285 mL	16.6423 mL	33.2845 mL	83.2113 mL
	5 mM	0.6657 mL	3.3285 mL	6.6569 mL	16.6423 mL
	10 mM	0.3328 mL	1.6642 mL	3.3285 mL	8.3211 mL
	15 mM	0.2219 mL	1.1095 mL	2.2190 mL	5.5474 mL
	20 mM	0.1664 mL	0.8321 mL	1.6642 mL	4.1606 mL
	25 mM	0.1331 mL	0.6657 mL	1.3314 mL	3.3285 mL
	30 mM	0.1109 mL	0.5547 mL	1.1095 mL	2.7737 mL
	40 mM	0.0832 mL	0.4161 mL	0.8321 mL	2.0803 mL
	50 mM	0.0666 mL	0.3328 mL	0.6657 mL	1.6642 mL
	60 mM	0.0555 mL	0.2774 mL	0.5547 mL	1.3869 mL
	80 mM	0.0416 mL	0.2080 mL	0.4161 mL	1.0401 mL

9-cis-Retinoic acid Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Alitretinoin (Synonyms: 9-cis-Retinoic acid; 9-cis-レチノイン酸)

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Complete Stock Solution Preparation Table

9-cis-Retinoic acid Related Classifications

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The molarity calculator equation

The dilution calculator equation

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Alitretinoin (Synonyms: 9-cis-Retinoic acid; 9-cis-レチノイン酸)

カスタマーレビュー

Other Forms of 9-cis-Retinoic acid:

Alitretinoin 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

RAR/RXR アイソフォーム固有の製品をすべて表示:

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Alitretinoin 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

9-cis-Retinoic acid Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

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