2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Antibiotic DNA/RNA Synthesis
  4. Azaserine

Azaserine  (Synonyms: アザセリン; CI-337; O-Diazoacetyl-L-serine; P-165)

製品番号: HY-B0919 純度: 99.57%
COA 取扱説明書 Technical Support

Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 115-02-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 66 在庫あり
Solution
10 mM * 1 mL in Water USD 66 在庫あり
Solid
5 mg $60 在庫あり
10 mg $112 在庫あり
25 mg $246 在庫あり
50 mg $432 在庫あり
100 mg $735 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 5 publication(s) in Google Scholar

Other Forms of Azaserine:

Azaserine 関連抗体

Top Publications Citing Use of Products

    Azaserine purchased from MedChemExpress. Usage Cited in: Vet Med Sci. 2025 Mar;11(2):e70294.  [Abstract]

    To study the effect of glucose on the development of GCs as mediated by GLUT, the glucose inhibitor Azaserine (5 µM) was added to GC cultures, which eliminated the FSH-induced glucose uptake capacity of the GCs.

    Azaserine purchased from MedChemExpress. Usage Cited in: Vet Med Sci. 2025 Mar;11(2):e70294.  [Abstract]

    Azaserine (5 μM) significantly reduced the viability of the GCs.

    Azaserine purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2023 Mar 20;55(8):1288-1300.  [Abstract]

    Fluorescence images of BODIPY-C11-stained SW1990 pancreatic cancer cells cultured for 48 h in glutamine-free medium, medium containing 2 mM glutamine, or medium containing 2 mM glutamine supplemented with 50 μM diazooxonorleucine (Don) or 10 μM Azaserine (Aza). Cells treated with 10 μM RSL3 or 20 μM erastin were used as positive controls. Blue, DAPI; green, BODIPY-C11 (oxidized).

    Azaserine purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2023 Mar 20;55(8):1288-1300.  [Abstract]

    Fluorescence images of BODIPY-C11-stained SU.8686 pancreatic cancer cells cultured for 48 h in glutamine-free medium, medium containing 2 mM glutamine, or medium containing 2 mM glutamine supplemented with 50 μM diazooxonorleucine (Don) or 10 μM Azaserine (Aza). Cells treated with 10 μM RSL3 or 20 μM erastin were used as positive controls. Blue, DAPI; green, BODIPY-C11 (oxidized).

    Azaserine purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2023 Mar 20;55(8):1288-1300.  [Abstract]

    Proportion of BODIPY-C11 evaluated by flow cytometry in SU.8686 cells cultured for 48 h in glutamine-free medium, medium containing 2 mM glutamine, or media containing 2 mM glutamine supplemented with 50 μM Don or 10 μM Azaserine.

    Azaserine purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2023 Mar 20;55(8):1288-1300.  [Abstract]

    Proportion of BODIPY-C11 evaluated by flow cytometry in SW1990 cells cultured for 48 h in glutamine-free medium, medium containing 2 mM glutamine, or media containing 2 mM glutamine supplemented with 50 μM Don or 10 μM Azaserine.

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection[1][2][3][4][5].

    体外実験

    Azaserine (100 μg/mL; 6 h) causes some specific types of morphological changes of the sensitive organisms such as the characteristic elongation of Candida albicans cells[2].
    Azaserine (0-10 μM) inhibits the growth of E. coli strains with MIC values of 12.11, 51.9, 69.2 and 69.2 μg/mL for UTH 4, UTH 7036, UTH 7048 and UTH 7049[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Azaserine 関連抗体
    体内実験

    Azaserine (5 mg/kg; i.p. once or twice a week for 6 months) induces tumor in rats[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Wistar rats[1]
    Dosage: 5 mg/kg
    Administration: Intraperitoneal injection; 5 mg/kg once or twice a week for 6 month
    Result: After 1 year most pancreases from treated rats were diffusely abnormal and contained many hyperplastic nodules and adenomas and more than rats one-quarter showed pancreatic adenocarcinoma.
    分子量

    173.13

    分子式

    C5H7N3O4
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    N[C@@H](COC(C=[N+]=[N-])=O)C(O)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 50 mg/mL (288.80 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.7760 mL 28.8800 mL 57.7601 mL
    5 mM 1.1552 mL 5.7760 mL 11.5520 mL
    10 mM 0.5776 mL 2.8880 mL 5.7760 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

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    濃度 （終了）

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.96%

    COA (244 KB) HNMR (178 KB) LCMS (90 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.7760 mL 28.8800 mL 57.7601 mL 144.4002 mL
    5 mM 1.1552 mL 5.7760 mL 11.5520 mL 28.8800 mL
    10 mM 0.5776 mL 2.8880 mL 5.7760 mL 14.4400 mL
    15 mM 0.3851 mL 1.9253 mL 3.8507 mL 9.6267 mL
    20 mM 0.2888 mL 1.4440 mL 2.8880 mL 7.2200 mL
    25 mM 0.2310 mL 1.1552 mL 2.3104 mL 5.7760 mL
    30 mM 0.1925 mL 0.9627 mL 1.9253 mL 4.8133 mL
    40 mM 0.1444 mL 0.7220 mL 1.4440 mL 3.6100 mL
    50 mM 0.1155 mL 0.5776 mL 1.1552 mL 2.8880 mL
    60 mM 0.0963 mL 0.4813 mL 0.9627 mL 2.4067 mL
    80 mM 0.0722 mL 0.3610 mL 0.7220 mL 1.8050 mL
    100 mM 0.0578 mL 0.2888 mL 0.5776 mL 1.4440 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Azaserine Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Azaserine115-02-6CI-337 O-Diazoacetyl-L-serine P-165CI337CI 337P165P 165P-165BacterialAntibioticDNA/RNA Synthesiscompetitiveantibacterialantibioticanti-tumortumor inducerE. coliCandida albicansratInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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