115-02-6
115-02-6
Chemical Structure
Azaserine
Synonym(s): CI-337; O-Diazoacetyl-L-serine; P-165
- CAS No.: 115-02-6
- Formula:C5H7N3O4
- Molecular Weight:173.13
IUPAC Name: O-(2-diazoacetyl)-L-serine
InChIKey: MZZGOOYMKKIOOX-VKHMYHEASA-N
SMILES: N[C@@H](COC(C=[N+]=[N-])=O)C(O)=O
Biological Activity: Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Azaserine | 99.57% | Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection. | ||||||||||||||||||||
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Azaserine (Standard) | ≥98% | Bamethan (hemisulfate) (Standard) is the analytical standard of Bamethan (hemisulfate). This product is intended for research and analytical applications. Bamethan (DL-Bamethane) hemisulfate is a vasodilator that exhibits significant activity in enhancing blood flow and reducing vascular resistance. Bamethan hemisulfate plays a crucial role in the treatment of cardiovascular conditions by improving oxygen delivery to tissues. Bamethan hemisulfate also aids in the management of hypertension through its relaxing effects on blood vessels. | ||||||||||||||||||||
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References
- [1]. Longnecker DS, Curphey TJ. Adenocarcinoma of the pancreas in azaserine-treated rats. Cancer Res. 1975 Aug;35(8):2249-58. [Content Brief]
- [2]. Shigemichi GUNJI, et al. Screening of Antifungal Antibiotics According to Activities Inducing Morphological Abnormalities. Agric. Biol Chem., 47 (9), 2061-2069, 1983.
- [3]. Williams MV, Tritz GJ. Studies on the modes of action of azaserine inhibition of Escherichia coli. Potentiation of phenylalanine reversal. J Antimicrob Chemother. 1977 Jan;3(1):65-77. [Content Brief]
- [4]. Catane R, et al. Azaserine, DON, and azotomycin: three diazo analogs of L-glutamine with clinical antitumor activity. Cancer Treat Rep. 1979 Jun;63(6):1033-8. [Content Brief]
- [5]. Lyons SD, et al. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. J Biol Chem. 1990 Jul 5;265(19):11377-81. [Content Brief]
Keywords
