Clofazimine (Synonyms: クロファジミン)

Name: Clofazimine
Brand: MedChemExpress
SKU: HY-B1046
Rating: 5.0 (12 reviews)

製品番号: HY-B1046 純度: 99.79%: Data Sheet SDS COA 取扱説明書
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Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC₅₀ = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 2030-63-9

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 41	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 41	在庫あり	Estimated Time of Arrival: December 31
Solid
500 mg	$38	在庫あり	Estimated Time of Arrival: December 31
1 g	$60	在庫あり	Estimated Time of Arrival: December 31
5 g	$170	在庫あり	Estimated Time of Arrival: December 31
10 g	$286	在庫あり	Estimated Time of Arrival: December 31
50 g		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 12 publication(s) in Google Scholar

Other Forms of Clofazimine:

Clofazimine-d₇ 在庫あり
Clofazimine (Standard) お問い合わせ

顧客検証

RT-PCR

In Vivo Efficacy Study

Cell Proliferation/Viability Assay

Flow Cytometry

: Clofazimine purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Mar 21;11(12):eads9182. [Abstract]; Clofazimine (15 μM; 24 h) significantly blocked OA-induced expression of H3K4me3-controlled genes AGR2 and PARM1, with a trend toward reduced PHGDH and NTRK2 expression in microstructures from BRCA1 wild-type individuals.

: Clofazimine purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Oct 6;8(1):1425. [Abstract]; Clofazimine (CFZ) (3.125 μg/mL; 48 h) markedly reduced the survival of ΔcysE Mycobacterium tuberculosis H37Rv.

: Clofazimine purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Oct 6;8(1):1425. [Abstract]; Clofazimine (CFZ) (15.625-31.25 μg/mL; 1-3 h) strongly increased ROS levels in M. tb (Mycobacterium tuberculosis).

: Clofazimine purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Oct 6;8(1):1425. [Abstract]; Early-log-phase cultures of WT and ΔcysE M. tb (Mycobacterium tuberculosis) were treated with or without Clofazimine (CFZ) (3.125–6.25 μg/mL; 7 d). Survival was determined in the form of viable bacterial count expressed as CFU.

: Clofazimine purchased from MedChemExpress. Usage Cited in: Patent. US20250312336A1.; The weights of orthotopic syngeneic pancreatic tumors from C57BL/6J mice followed treatment with ANO6 inhibitors Clofazimine (50 mg/kg; p.o.; 3 weeks).

: Clofazimine purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2022 Mar 12;8(1):111. [Abstract]; Clofazimine (Verteporfin) (5 μM) reduced the expression of steogenesis related genes (RUNX2, ALP, OSX) in BMSCs.

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すべてのアイソフォームを表示

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

Quinolone

Cellular Effect

Cell Line	Type	Value	Description	References
BT-20	IC₅₀	19 μM Compound: Clofazimine	Cytotoxicity against human BT-20 cells incubated for 3 to 4 days by MTT assay Cytotoxicity against human BT-20 cells incubated for 3 to 4 days by MTT assay	[PMID: 34116325]
HMEC-1	CC₅₀	18.6 μM Compound: CFM	Cytotoxicity against human HMEC1 cells assessed as reduction in cell viability after 72 hrs by MTT method Cytotoxicity against human HMEC1 cells assessed as reduction in cell viability after 72 hrs by MTT method	[PMID: 25464882]
HMEC-1	IC₅₀	18.59 μM Compound: Clofazimine	Cytotoxicity against HMEC1 cells after 72 hrs by MTT assay Cytotoxicity against HMEC1 cells after 72 hrs by MTT assay	[PMID: 25497962]
HepG2	CC₅₀	49.02 μg/mL Compound: CLFZ	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay	[PMID: 38784457]
Huh-7	CC₅₀	44.7 μM Compound: 1	Cytotoxicity against human HuH-7 cells assessed as reduction in cell viability incubated for 24 hrs by microplate reader assay Cytotoxicity against human HuH-7 cells assessed as reduction in cell viability incubated for 24 hrs by microplate reader assay	[PMID: 35279610]
MT4	CC₅₀	6.8 μM Compound: CFM	Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 96 hrs by MTT method Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 96 hrs by MTT method	[PMID: 25464882]
NIH-3T3-G185	IC₅₀	0.6 μM Compound: Clofazimine	TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	1 μM Compound: Clofazimine	TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	1.1 μM Compound: Clofazimine	TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells	[PMID: 11716514]
Vero	IC₅₀	68.6 μg/mL Compound: CFZ	Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay	[PMID: 22931472]
Vero 76	CC₅₀	> 100 μM Compound: CFM	Cytotoxicity against african green monkey Vero 76 cells assessed as reduction in cell viability after 48 to 96 hrs by MTT method Cytotoxicity against african green monkey Vero 76 cells assessed as reduction in cell viability after 48 to 96 hrs by MTT method	[PMID: 25464882]

体外実験

Clofazimine (0.0625-2 mg/L, 14 d) exerts no apparent activity against M. tuberculosis during the first 2–4 days of exposure, exhibits a concentration-dependent antimicrobial activity after 1 week: bacteriostatic activity at concentrations at or below the 0.25 mg/L MIC and bactericidal activity at concentrations above the MIC. INH is used as positive control.^[3].
Clofazimine (10 μM, 24 h) inhibits the growth of hematological cancer cell lines (Jurkat, U266, Namalwa, K562, HL60)^[4].
Clofazimine (1-50 μM, 12-48 h) shows a dose- and time-dependent inhibitory effect for U266^[4].
Clofazimine (10 μM, 24-48 h) depolarizes the mitochondrial membrane, significantly increases active caspase-3 level (25-fold) and increases the percentage of early and late apoptotic cells in U266^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Clofazimine (100,50 mg/kg, p.o., once per day for 14 d) exhibits a delayed antimicrobial activity against Mycobacterium tuberculosis in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c mice (age 6–8 weeks, mass 18–20 g)^[3]
Dosage:	100, 50, 25, 12.5, 6.25, 3.125 or 1.5625 mg/kg
Administration:	Oral gavage (p.o.), once per day for 14 d
Result:	Exhibited an increase of the lung bacterial load during the first 7 days of treatment, and decreased the CFU counts in the lungs of mice after 10 days of treatment. Significantly declined the lung CFU counts in 100 or 50 mg/ kg group at 14th day.

臨床実験

分子量

473.40

分子式

C₂₇H₂₂Cl₂N₄

CAS 番号

2030-63-9

Appearance

Solid

Color

Pink to red

SMILES

CC(/N=C1C(NC2=CC=C(Cl)C=C2)=CC3=NC4=C(C=CC=C4)N(C5=CC=C(Cl)C=C5)C3=C/1)C

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 6.25 mg/mL (13.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1124 mL	10.5619 mL	21.1238 mL
5 mM	0.4225 mL	2.1124 mL	4.2248 mL
10 mM	0.2112 mL	1.0562 mL	2.1124 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.79%

Select Batch:

データシート (279 KB) SDS (396 KB)

COA (251 KB) RP-HPLC (244 KB) MS (68 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Riccardi N, et al. Clofazimine: an old drug for never-ending diseases. Future Microbiol. 2020，15:557-566. [Content Brief]

[2]. Arbiser JL, et al. Clofazimine: a review of its medical uses and mechanisms of action. J Am Acad Dermatol. 1995 Feb;32(2 Pt 1):241-7. [Content Brief]

[3]. Ammerman NC, et al. Clofazimine has delayed antimicrobial activity against Mycobacterium tuberculosis both in vitro and in vivo. J Antimicrob Chemother. 2017，72(2):455-461. [Content Brief]

[4]. Durusu İZ, et al. Anti-cancer effect of clofazimine as a single agent and in combination with cisplatin on U266 multiple myeloma cell line. Leuk Res. 2017，55:33-40. [Content Brief]

[5]. Ren YR, et al. Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes. PLoS One. 2008，3(12):e4009. [Content Brief]

[6]. Cholo MC, et al. Clofazimine: current status and future prospects. J Antimicrob Chemother. 2012 Feb;67(2):290-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1124 mL	10.5619 mL	21.1238 mL	52.8095 mL
	5 mM	0.4225 mL	2.1124 mL	4.2248 mL	10.5619 mL
	10 mM	0.2112 mL	1.0562 mL	2.1124 mL	5.2809 mL

Clofazimine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Clofazimine (Synonyms: クロファジミン)

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生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Clofazimine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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Clofazimine (Synonyms: クロファジミン)

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Other Forms of Clofazimine:

Clofazimine 関連抗体

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•関連小分子:

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Antibiotic アイソフォーム固有の製品をすべて表示:

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

Interleukin Related アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Clofazimine 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Clofazimine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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