2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Endogenous Metabolite GABA Receptor iGluR
  4. Creatinine

クレアチニ  (Synonyms: Creatinine; NSC13123)

製品番号: HY-B0504 純度: 99.92%
COA 取扱説明書 Technical Support

Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.

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Creatinine

クレアチニ 構造式

CAS 番号 : 60-27-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
500 mg $50 在庫あり
1 g $60 在庫あり
5 g $72 在庫あり
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Based on 6 publication(s) in Google Scholar

Other Forms of Creatinine:

クレアチニ 関連抗体

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AMPA Receptor NMDA Receptor Kainate Receptor

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製品説明

Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure[1][2][3][4].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

NMDA Receptor

 

体外実験

Creatinine (20-180 μM; 24 h) induces a hypermetabolic state in primary inguinal and epididymal adipocytes by activating the futile creatine cycle. 20 μM Creatinine activates inguinal adipocytes, while 180 μM Creatinine activates both inguinal and epididymal adipocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

クレアチニ 関連抗体
体内実験

Creatinine (0.1 g/kg; i.p.; daily; 7 d) exacerbates adipose tissue wasting in mice with Unilateral Ureteral Obstruction (UUO)- or renal Ischemia-Reperfusion Injury (IRI)-induced chronic kidney disease (CKD) by increasing creatine accumulation and activating pathways associated with the futile creatine cycle[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 wild type mouse with Chronic kidney disease (male, 8 weeks old, unilateral ureteral obstruction model)[1]
Dosage: 0.1 g/kg
Administration: i.p.; daily; 7 days
Result: Enhanced loss of inguinal (subcutaneous) and epididymal (visceral) adipose tissues relative to UUO-only mice; increased creatine levels in both subcutaneous and visceral adipose tissues; increased the proportion of multilocular adipocytes in both subcutaneous and visceral adipose tissues; upregulated expression of Prdm16, Pgc1α, CKB, Alpl, and Cox7a genes in subcutaneous and visceral adipose tissues
臨床実験
分子量

113.12

分子式

C4H7N3O
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(N)N(C)C1
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 33.33 mg/mL (294.64 mM; Need ultrasonic)

DMSO : 2.5 mg/mL (22.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.8402 mL 44.2008 mL 88.4017 mL
5 mM 1.7680 mL 8.8402 mL 17.6803 mL
10 mM 0.8840 mL 4.4201 mL 8.8402 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 33.33 mg/mL (294.64 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 8.8402 mL 44.2008 mL 88.4017 mL 221.0042 mL
5 mM 1.7680 mL 8.8402 mL 17.6803 mL 44.2008 mL
10 mM 0.8840 mL 4.4201 mL 8.8402 mL 22.1004 mL
15 mM 0.5893 mL 2.9467 mL 5.8934 mL 14.7336 mL
20 mM 0.4420 mL 2.2100 mL 4.4201 mL 11.0502 mL
H2O 25 mM 0.3536 mL 1.7680 mL 3.5361 mL 8.8402 mL
30 mM 0.2947 mL 1.4734 mL 2.9467 mL 7.3668 mL
40 mM 0.2210 mL 1.1050 mL 2.2100 mL 5.5251 mL
50 mM 0.1768 mL 0.8840 mL 1.7680 mL 4.4201 mL
60 mM 0.1473 mL 0.7367 mL 1.4734 mL 3.6834 mL
80 mM 0.1105 mL 0.5525 mL 1.1050 mL 2.7626 mL
100 mM 0.0884 mL 0.4420 mL 0.8840 mL 2.2100 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Creatinine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Creatinine60-27-5NSC13123NSC 13123NSC-13123Endogenous MetaboliteGABA ReceptoriGluRGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorIonotropic glutamate receptorsCryptococcus bacillisporuscreatinine deiminaseprimary epididymal adipocytesprimary inguinal adipocytesGABAA receptorNMDA receptorCryptococcus neoformansone-carbon metabolismglomerular filtration rateUUO-induced CKD miceInhibitorinhibitorinhibit

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