2. Anti-infection Autophagy
  3. Bacterial HIV Autophagy Antibiotic
  4. Erythromycin Ethylsuccinate

Erythromycin Ethylsuccinate  (Synonyms: Erythromycin ethyl succinate; EES)

Cat. No.: HY-B0957 Pureté: 79.0%
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Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin Ethylsuccinate has antiviral activity against HIV-1.

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Erythromycin Ethylsuccinate

Erythromycin Ethylsuccinate Chemical Structure

CAS No. : 1264-62-6

Size Prix Stock Quantité
Échantillon gratuit (0.1 - 0.2 mg)   Appliquer maintenant  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
200 mg En stock
500 mg En stock
1 g   Obtenir un devis  
5 g   Obtenir un devis  

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Other Forms of Erythromycin Ethylsuccinate:

Erythromycin Ethylsuccinate Related Antibodies

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Description

Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin Ethylsuccinate has antiviral activity against HIV-1.

IC50 & Target

HIV-1

 

In Vivo

Low-dose Erythromycin Ethylsuccinate (0.125-1.25 mg/kg, p.o., once daily for 3-5 days) induces acute colitis in Swedish Warmblood horses[1].
Erythromycin Ethylsuccinate (100 mg/kg, p.o., once daily for 21 days) significantly improved splicing defects in the DM1 mouse model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HSALR transgenic mouse model (obtained by the integration of the DMPK gene)
Dosage: 100 mg/kg
Administration: Oral gavage, p.o., once daily for 21 days
Result: Significantly improved missplicing of Clcn1 and Atp2a1 and alleviated myotonia.
Animal Model: Swedish Warmblood[1]
Dosage: 1.25 mg/kg, 0.125 mg/kg, 0.25 mg/kg
Administration: Oral gavage (p.o.), once daily for 3-5 days
Result: Induced acute colitis, with severe diarrhea, dehydration, fever, and toxemia.
Essai clinique
Masse moléculaire

862.05

Formule

C43H75NO16
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCC(OCC)=O)O[C@H]([C@H]1N(C)C)[C@](O[C@H](C)C1)([H])O[C@@H]([C@](O)(C[C@H](C([C@@H]([C@@H](O)[C@@]2(O)C)C)=O)C)C)[C@H]([C@@H]([C@H](C(O[C@@H]2CC)=O)C)O[C@@](O[C@@H](C)[C@@H]3O)([H])C[C@@]3(C)OC)C
Structure Classification
Initial Source

Saccharopolyspora erythraea
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvant et solubilité
In Vitro: 

DMSO : ≥ 50 mg/mL (58.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 33.33 mg/mL (38.66 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1600 mL 5.8001 mL 11.6003 mL
5 mM 0.2320 mL 1.1600 mL 2.3201 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (2.90 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (2.90 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 1.1600 mL 5.8001 mL 11.6003 mL 29.0006 mL
5 mM 0.2320 mL 1.1600 mL 2.3201 mL 5.8001 mL
10 mM 0.1160 mL 0.5800 mL 1.1600 mL 2.9001 mL
15 mM 0.0773 mL 0.3867 mL 0.7734 mL 1.9334 mL
20 mM 0.0580 mL 0.2900 mL 0.5800 mL 1.4500 mL
25 mM 0.0464 mL 0.2320 mL 0.4640 mL 1.1600 mL
30 mM 0.0387 mL 0.1933 mL 0.3867 mL 0.9667 mL
DMSO 40 mM 0.0290 mL 0.1450 mL 0.2900 mL 0.7250 mL
50 mM 0.0232 mL 0.1160 mL 0.2320 mL 0.5800 mL
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Erythromycin Ethylsuccinate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Erythromycin Ethylsuccinate1264-62-6Erythromycin ethyl EESBacterialHIVAutophagyAntibioticHuman immunodeficiency virusHSALR transgenic mouse modelAnti-infectionInhibitorinhibitorinhibit

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