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  3. Environmental Pollutants Bacterial Antibiotic
  4. Gentamicin sulfate

Gentamicin (sulfate)  (Synonyms: ゲンタマイシン硫酸塩)

製品番号: HY-A0276
COA 取扱説明書 Technical Support

Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits DNase I with an IC50 of 0.57 mM.

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CAS 番号 : 1405-41-0

容量 価格（税別） 在庫状況 数量
500 mg $60 在庫あり
1 g $84 在庫あり
5 g $180 在庫あり
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カスタマーレビュー

Based on 64 publication(s) in Google Scholar

Other Forms of Gentamicin sulfate:

Gentamicin (sulfate) 関連抗体

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顧客検証

Microbiological Assay

    Gentamicin sulfate purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575.

    Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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    製品説明

    Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits DNase I with an IC50 of 0.57 mM[1][2][3].

    IC50 & Target

    Aminoglycoside

     

    体外実験

    Gentamicin sulfate is a more effective in vitro bacterial inhibitor than combined penicillin-streptomycin, is nontoxic to tissue culture monolayers, and does not inhibit virus replication[2].
    Gentamicin sulfate has been used with success as an additive in commercial mycology media to inhibit growth of bacteria and has been shown to be bactericidal for a wider range of organisms (Pseudomonas aeruginosa, Proteus sp., and Streptococcus faecalis) than penicillin and streptomycin[2].
    Gentamicin sulfate does not interfere with the production of cytopathic effect by certain echoviruses and polioviruses in tissue culture, is nontoxic to Rhesus monkey kidney, HeLa, and human amnion cells, and is stable at autoclave temperatures[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Gentamicin (sulfate) 関連抗体
    体内実験

    Gentamicin (10 mg/kg; s.c.; every 12 h for a total of six doses) sulfate improves survival and alters the inflammatory profile in a murine model of depsis from P. aeruginosa[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: FVB/N mice (6-10-week-old; ~20 g) received an intratracheal injection of a solution containing the ATCC 27853 strain of P. aeruginosa[3].
    Dosage: 10 mg/kg
    Administration: Subcutaneous injection (s.c.); every 12 h for a total of six doses
    Result: Survival at 7 days was 100% for mice. Down-regulated the proinflammatory cytokines, IL-6.
    臨床実験
    分子量

    561.65 (Average)

    分子式

    C24H55N7O11S3*
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=S(O)(O)=O.O[C@]1(C)C(NC)[C@@H](O)[C@@H](O[C@H]2C(N)C[C@H](N)[C@@H](O[C@@H]3[C@H](N)CC[C@@H]([R])O3)[C@@H]2O)OC1.NC[*].C[C@H]([*])N.C[C@H]([*])NC.[R=].[or].[or]
    Structure Classification
    Initial Source

    Micromonospora purpurea
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

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    一般には略語で表示されます：C1V1 = C2V2

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    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL; Clear solution; Need ultrasonic

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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    COA (249 KB)

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    Gentamicin sulfate Related Classifications

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    質量   濃度   体積   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Gentamicin1405-41-0Environmental PollutantsBacterialAntibioticEnvironmental ContaminantsMeniere’s diseaseglandular tularemiaorally activeInhibitorinhibitorinhibit

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    製品番号:
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