Gentamicin sulfate

Name: Gentamicin sulfate
Brand: MedChemExpress
SKU: HY-A0276
Rating: 5.0 (64 reviews)

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Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits DNase I with an IC₅₀ of 0.57 mM.

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CAS No. : 1405-41-0

Size	Stock	Quantité
500 mg	En stock	Estimated Time of Arrival: December 31
1 g	En stock	Estimated Time of Arrival: December 31
5 g	En stock	Estimated Time of Arrival: December 31
10 g	Obtenir un devis
50 g	Obtenir un devis

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Based on 64 publication(s) in Google Scholar

Other Forms of Gentamicin sulfate:

Gentamicin In-stock

64 Publications Citing Use of MCE Gentamicin sulfate

Microbiological Assay

: Gentamicin sulfate purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575.; Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Description

IC₅₀ & Target

Aminoglycoside

In Vitro

Gentamicin sulfate is a more effective in vitro bacterial inhibitor than combined penicillin-streptomycin, is nontoxic to tissue culture monolayers, and does not inhibit virus replication^[2].
Gentamicin sulfate has been used with success as an additive in commercial mycology media to inhibit growth of bacteria and has been shown to be bactericidal for a wider range of organisms (Pseudomonas aeruginosa, Proteus sp., and Streptococcus faecalis) than penicillin and streptomycin^[2].
Gentamicin sulfate does not interfere with the production of cytopathic effect by certain echoviruses and polioviruses in tissue culture, is nontoxic to Rhesus monkey kidney, HeLa, and human amnion cells, and is stable at autoclave temperatures^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Gentamicin (10 mg/kg; s.c.; every 12 h for a total of six doses) sulfate improves survival and alters the inflammatory profile in a murine model of depsis from P. aeruginosa^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	FVB/N mice (6-10-week-old; ~20 g) received an intratracheal injection of a solution containing the ATCC 27853 strain of P. aeruginosa^[3].
Dosage:	10 mg/kg
Administration:	Subcutaneous injection (s.c.); every 12 h for a total of six doses
Result:	Survival at 7 days was 100% for mice. Down-regulated the proinflammatory cytokines, IL-6.

Essai clinique

Masse moléculaire

561.65 (Average)

Formule

C₂₄H₅₅N₇O₁₁S^3*

CAS No.

1405-41-0

Appearance

Solid

Color

White to off-white

SMILES

O=S(O)(O)=O.O[C@]1(C)C(NC)[C@@H](O)[C@@H](O[C@H]2C(N)C[C@H](N)[C@@H](O[C@@H]3[C@H](N)CC[C@@H]([R])O3)[C@@H]2O)OC1.NC[*].C[C@H]([*])N.C[C@H]([*])NC.[R=].[or].[or]

Structure Classification

Initial Source

Microorganisms

Micromonospora purpurea

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Calculateur de molarité
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL; Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

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Fiche technique (275 KB) SDS (393 KB)

COA (249 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Xu W, et al. A rapid and sensitive method for kinetic study and activity assay of DNase I in vitro based on a GO-quenched hairpin probe. Anal Bioanal Chem. 2016 May;408(14):3801-9. [Content Brief]

[2]. Rudin A, et al. Antibacterial activity of gentamicin sulfate in tissue culture. Appl Microbiol. 1970 Dec;20(6):989-90. [Content Brief]

[3]. Coopersmith CM, et al. Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia. Shock. 2003 May;19(5):408-14. [Content Brief]