2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis Endogenous Metabolite
  4. Guanine

グアニン  (Synonyms: Guanine)

製品番号: HY-Y1055 純度: 98.0%
COA 取扱説明書 Technical Support

Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects.

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Guanine

グアニン 構造式

CAS 番号 : 73-40-5

容量 価格（税別） 在庫状況 数量
100 mg $25 在庫あり
500 mg $40 在庫あり
1 g $50 在庫あり
5 g $80 在庫あり
10 g $96 在庫あり
50 g $155 在庫あり
100 g $186 在庫あり
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カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Other Forms of Guanine:

グアニン 関連抗体

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DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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Human Endogenous Metabolite Microbial Metabolite

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製品説明

Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

Microbial Metabolite

 

Fungal Metabolite

 

Cellular Effect
Cell Line Type Value Description References
A-431 IC50
> 100 μg/mL
Compound: guanine
Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting
Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting
[PMID: 1666120]
CCRF-CEM IC50
64.3 μM
Compound: Guanine
Cytotoxicity was determined in CEM cells, relative to RVT
Cytotoxicity was determined in CEM cells, relative to RVT
[PMID: 15081000]
Vero CC50
136.5 μM
Compound: R7
Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by neutral red uptake assay
Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by neutral red uptake assay
[PMID: 27933947]
Vero IC50
11.5 μM
Compound: R7
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay
[PMID: 27933947]
Vero IC50
54.9 μM
Compound: Guanine
Cytotoxicity was determined in Vero cells, relative to RVT
Cytotoxicity was determined in Vero cells, relative to RVT
[PMID: 15081000]
体外実験

Guanine (1 h) inhibits Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells, with IC50 of 11.5 μM[2].
Guanine (24 h) shows cytotoxicity against African green monkey Vero cells, with CC50 of 136.5 μM[2].
Guanine (10 μM, 16-40 h) partially antagonizes the cytostatic effect of Mycophenolic acid (HY-B0421) on LAN5 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

グアニン 関連抗体
体内実験

Guanine (600 nmol; i.t.) inhibits spinal glutamate- and AMPA-induced biting behaviour in mice[4].
Guanine (200-600 nmol; i.t.) produces A1 adenosine receptor-mediated antinociception against intraplantar glutamate-, Capsaicin (HY-10448)-, and Acetic acid (HY-Y0319)-induced pain in mice, with ID50 values of 107, 84, and 48 nmol and maximal inhibitions of 48%, 58%, and 56%, respectively[4].
Guanine (200-600 nmol; i.t.) produces dose-dependent antinociception against tail-flick test thermal nociception in mice, with peak efficacy at 400 nmol yielding ~78% MPE[4].
Guanine (200-600 nmol; i.t.) dose-dependently increases CSF levels of inosine, xanthine, and uric acid, with a significant increase in AMP at the highest dose[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino (male, 3-4 months of age, 30-40 g)[4]
Dosage: 200 nmol; 400 nmol; 600 nmol
Administration: i.t.
Result: Produced dose-dependent antinociception with maximal inhibition of 48% (ID50 = 107 nmol), 58% (ID50 = 84 nmol), and 56% (ID50 = 48 nmol); 200-600 nmol elicited significant MPE (56%-78%).
Dose-dependently elevated CSF inosine (200 nmol: 5.12 μM; 400 nmol: 11.43 μM; 600 nmol: 13.60 μM), AMP (600 nmol: 1.49 μM), xanthine (400 nmol: 7.20 μM; 600 nmol: 8.38 μM) and uric acid (200 nmol: 6.85 μM; 400 nmol: 6.57 μM; 600 nmol: 5.54 μM) levels.
Animal Model: Swiss albino (male, 3-4 months of age, 30-40 g)[4]
Dosage: 600 nmol
Administration: i.t.
Result: Significantly reduced the duration of biting behaviour induced by spinal glutamate.
Significantly reduced the duration of biting behaviour induced by spinal AMPA.
分子量

151.13

分子式

C5H5N5O
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(N)NC2=C1NC=N2
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

0.5 M NaOH : 10 mg/mL (66.17 mM; ultrasonic and adjust pH to 12 with NaOH)

DMSO : 0.15 mg/mL (0.99 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.6168 mL 33.0841 mL 66.1682 mL
5 mM 1.3234 mL 6.6168 mL 13.2336 mL
10 mM 0.6617 mL 3.3084 mL 6.6168 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 98.0%

COA (249 KB) HNMR (245 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.5 M NaOH 1 mM 6.6168 mL 33.0841 mL 66.1682 mL 165.4205 mL
5 mM 1.3234 mL 6.6168 mL 13.2336 mL 33.0841 mL
10 mM 0.6617 mL 3.3084 mL 6.6168 mL 16.5420 mL
15 mM 0.4411 mL 2.2056 mL 4.4112 mL 11.0280 mL
20 mM 0.3308 mL 1.6542 mL 3.3084 mL 8.2710 mL
25 mM 0.2647 mL 1.3234 mL 2.6467 mL 6.6168 mL
30 mM 0.2206 mL 1.1028 mL 2.2056 mL 5.5140 mL
40 mM 0.1654 mL 0.8271 mL 1.6542 mL 4.1355 mL
50 mM 0.1323 mL 0.6617 mL 1.3234 mL 3.3084 mL
60 mM 0.1103 mL 0.5514 mL 1.1028 mL 2.7570 mL
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Guanine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanine73-40-5DNA/RNA SynthesisEndogenous MetaboliteDNARNAnucleic acidspurinederivativeN poolInhibitorinhibitorinhibit

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