Maltitol

Cat. No.: HY-B2122 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Maltitol is an orally active polyol and sugar alcohol sweetener produced by the hydrogenation of maltose. Maltitol can replace sucrose and has characteristics of having a minor impact on blood sugar and potential prebiotic effects.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Maltitol 화학구조

CAS No. : 585-88-6

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	해외재고보유	Estimated Time of Arrival: December 31
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	해외재고보유	Estimated Time of Arrival: December 31
100 g	해외재고보유	Estimated Time of Arrival: December 31
> 100 g	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

Other Forms of Maltitol:

Maltitol (Standard) In-stock

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PPARα PPARβ/δ PPARγ PPAR PPARδ

Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vivo

Maltitol (5.0%; diet administration; 8 weeks) can prevent nonalcoholic fatty liver disease (NAFLD) in a mouse model of a high-fat diet^[2].
Maltitol (2.5-10 g/kg; intraperitoneal injection; single dose) is not genotoxic and not cytotoxic (to bone marrow cells) in rats. It does not induce chromosomal aberrations and does not reduce the mitotic index^[3].
Maltitol (1-4 g/kg; intraperitoneal injection; 7 days) is not teratogenic in pregnant rats, but at the highest dose (4 g/kg), it reduces fetal weight and causes growth retardation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old C57BL/6 male mice treated high-fat diet^[2]
Dosage:	5.0%
Administration:	Diet administration; 8 weeks
Result:	Significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia. Decreased the expression of sterol regulatory element-binding protein 1c (SREBP1c) mRNA. Increased the expressions of farnesoid X receptor (FXR), peroxisome proliferator-activated receptor α (PPARα), and hydroxymethylglutaryl-Co reductase in the liver.

Clinical Trial

분자량

344.31

화학식

C₁₂H₂₄O₁₁

CAS No.

585-88-6

Appearance

Solid

Color

White to off-white

SMILES

O[C@H](CO)[C@H]([C@H](O)[C@H](CO)O)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1

Structure Classification

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

H₂O : 175 mg/mL (508.26 mM; Need ultrasonic)

DMSO : 33.33 mg/mL (96.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9044 mL	14.5218 mL	29.0436 mL
5 mM	0.5809 mL	2.9044 mL	5.8087 mL
10 mM	0.2904 mL	1.4522 mL	2.9044 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 98.0%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (256 KB) HNMR (272 KB)

Handling Instructions (2659 KB)

References

[1]. Saraiva A, et al. Maltitol: Analytical Determination Methods, Applications in the Food Industry, Metabolism and Health Impacts. Int J Environ Res Public Health. 2020 Jul 20;17(14):5227. [Content Brief]

[2]. Urushima H, et al. Maltitol Prevents the Progression of Fatty Liver Degeneration in Mice Fed High-Fat Diets. J Med Food. 2015 Oct;18(10):1081-7. [Content Brief]

[3]. Canimoglu S, et al. The genotoxic and teratogenic effects of maltitol in rats. Toxicol Ind Health. 2013 Nov;29(10):935-43. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.9044 mL	14.5218 mL	29.0436 mL	72.6090 mL
	5 mM	0.5809 mL	2.9044 mL	5.8087 mL	14.5218 mL
	10 mM	0.2904 mL	1.4522 mL	2.9044 mL	7.2609 mL
	15 mM	0.1936 mL	0.9681 mL	1.9362 mL	4.8406 mL
	20 mM	0.1452 mL	0.7261 mL	1.4522 mL	3.6304 mL
	25 mM	0.1162 mL	0.5809 mL	1.1617 mL	2.9044 mL
	30 mM	0.0968 mL	0.4841 mL	0.9681 mL	2.4203 mL
	40 mM	0.0726 mL	0.3630 mL	0.7261 mL	1.8152 mL
	50 mM	0.0581 mL	0.2904 mL	0.5809 mL	1.4522 mL
	60 mM	0.0484 mL	0.2420 mL	0.4841 mL	1.2101 mL
	80 mM	0.0363 mL	0.1815 mL	0.3630 mL	0.9076 mL
H₂O	100 mM	0.0290 mL	0.1452 mL	0.2904 mL	0.7261 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Maltitol Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Maltitol585-88-6PPARFatty Acid Synthase (FASN)Peroxisome proliferator-activated receptorshigh-fat diet modelbone marrow cellssucroseInhibitorinhibitorinhibit

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Maltitol

Other Forms of Maltitol:

Maltitol Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PPAR Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

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