2. Natural Products
  3. Marine natural products
  4. Sponge

Sponge

Sponge (53):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13605
    Cytarabine 147-94-4 99.98%
    Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
    Cytarabine
  • HY-16929
    Latrunculin A 76343-93-6 98.9%
    Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration.
    Latrunculin A
  • HY-P0027
    Jasplakinolide 102396-24-7 99.56%
    Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity.
    Jasplakinolide
  • HY-101848
    Latrunculin B 76343-94-7 98.95%
    Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity.
    Latrunculin B
  • HY-13605R
    Cytarabine (Standard) 147-94-4
    Cytarabine (Standard) is the analytical standard of Cytarabine. This product is intended for research and analytical applications. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
    Cytarabine (Standard)
  • HY-N8255
    Puupehenone 73573-17-8
    Puupehenone is a cytotoxic and antifungal agent present in various marine sponge species. Puupehenone exerts cytotoxic activity against leukemia, lung cancer, colon cancer and breast cancer cells, and inhibits the growth of Candida albicans. Puupehenone can be used in research related to cancers such as leukemia, lung cancer, colon cancer and breast cancer.
    Puupehenone
  • HY-N18431
    Stellettamide A TFA 129744-24-7
    Stellettamide A TFA is a marine toxin found in a marine sponge. Stellettamide A TFA is a calmodulin inhibitor. Stellettamide A TFA can inhibit Ca2+/Mg2+ ATPase, phosphodiesterase, myosin light chain , and Mg2+-ATPase. Stellettamide A TFA inhibits high K+- and Ca2+-induced contraction in permeabilized smooth muscle. Stellettamide A TFA exhibits antifungal activity against Mortierella remannianus. Stellettamide A TFA can be used for the research of fungal infection.
    Stellettamide A TFA
  • HY-P2044
    Azumamide E 585535-37-1
    Azumamide E is a HDAC inhibitor, with an IC50 of 0.064 μM against HDAC, 1.22 μM against HDAC1, and 2.28 μM against HDAC4. Azumamide E inhibits HDAC activity in nuclear extracts of leukemia cells and cervical adenocarcinoma cells. Azumamide E suppresses angiogenesis. Azumamide E is applicable for research on leukemia, cervical adenocarcinoma, and anti-angiogenesis.
    Azumamide E
  • HY-W052289
    Methyl 6-bromo-1H-indole-3-carboxylate 868656-97-7 98.81%
    Methyl 6-bromo-1H-indole-3-carboxylate is a marine-derived natural product with anti-tumor activity. Methyl 6-bromo-1H-indole-3-carboxylate exhibits growth inhibitory effects against Staphylococcus epidermidis. Methyl 6-bromo-1H-indole-3-carboxylate can be used in research related to Staphylococcus epidermidis infection and cancer.
    Methyl 6-bromo-1H-indole-3-carboxylate
  • HY-117025A
    Manzamine A hydrochloride 104264-80-4 99.66%
    Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1.
    Manzamine A hydrochloride
  • HY-117371
    Hemiasterlin 157207-90-4 99.90%
    Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs).
    Hemiasterlin
  • HY-N4225
    Aaptamine 85547-22-4 99.71%
    Aaptamine is an alkaloid that can be isolated from the sponge Aaptos suberitoides. Aaptamine is a competitive antagonist of the α-adrenergic receptor, as well as an inhibitor of the proteasome and cholinesterase. Aaptamine is cytotoxic to tumor cells and can induce apoptosis, cell cycle arrest of tumor cells, and the expression of p21 through a p53-independent pathway. Aaptamine has multiple activities such as anti-tumor, antioxidant, antibacterial, and analgesic effects.
    Aaptamine
  • HY-N2150
    Psammaplin A 110659-91-1
    Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC50: 45 nM), DNA methyltransferases (IC50: 18.6 nM) and aminopeptidase N (APN) (IC50: 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis.
    Psammaplin A
  • HY-111009
    Swinholide A 95927-67-6 98.30%
    Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity.
    Swinholide A
  • HY-W006646
    Methyl 5-bromo-1H-pyrrole-2-carboxylate 934-07-6 98.43%
    Methyl 5-bromo-1H-pyrrole-2-carboxylate (Compound 7) is a pyrrole that can be isolated from marine sponges Lissodendotyx sp.
    Methyl 5-bromo-1H-pyrrole-2-carboxylate
  • HY-W011309A
    1-O-Hexadecyl-sn-glycerol 506-03-6 99.94%
    1-O-Hexadecyl-sn-glycerol [(S)-HXDG] is an alkyl glycerol monoether derived from T. aurantia.
    1-O-Hexadecyl-sn-glycerol
  • HY-W035305
    Methyl 2-(6-bromo-1H-indol-3-yl)acetate 152213-63-3 99.37%
    Methyl 2-(6-bromo-1H-indol-3-yl)acetate is a natural product derived from marine sources, specifically isolated from Pseudosuberites hyalinus.
    Methyl 2-(6-bromo-1H-indol-3-yl)acetate
  • HY-112328
    Fascaplysin 114719-57-2
    Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity.
    Fascaplysin
  • HY-N6794
    10Z-Hymenialdisine 82005-12-7
    10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities.
    10Z-Hymenialdisine
  • HY-N15451
    Deoxytopsentin 112515-42-1 99.42%
    Deoxytopsentin (compound 5) is a marine bisindole alkaloid and also a MRSA pyruvate kinase inhibitor. Deoxytopsentin exists in sponges. Deoxytopsentin exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus strains in vitro.
    Deoxytopsentin