Fascaplysin

Name: Fascaplysin
Brand: MedChemExpress
SKU: HY-112328
Rating: 4.5 (1 reviews)

Cat. No.: HY-112328 Purity: 95.64%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity.

For research use only. We do not sell to patients.

Fascaplysin Chemical Structure

CAS No. : 114719-57-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All CDK Isoform Specific Products:

View All Isoforms

CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

CDK4

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	6.7 μM Compound: 1, NSC-622398	Antitumor activity against human 786-O cells Antitumor activity against human 786-O cells	[PMID: 15165138]
A498	IC₅₀	5.2 μM Compound: 1, NSC-622398	Antitumor activity against human A498 cells Antitumor activity against human A498 cells	[PMID: 15165138]
A549	IC₅₀	0.69 μM Compound: 2	Growth inhibition of p53+, pRb+ human A549 cells after 48 hrs by MTT assay Growth inhibition of p53+, pRb+ human A549 cells after 48 hrs by MTT assay	[PMID: 25368960]
A549	IC₅₀	4.2 μM Compound: 1, NSC-622398	Antitumor activity against human A549/ATCC cells Antitumor activity against human A549/ATCC cells	[PMID: 15165138]
ACHN	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human ACHN cells Antitumor activity against human ACHN cells	[PMID: 15165138]
BT-549	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human BT549 cells Antitumor activity against human BT549 cells	[PMID: 15165138]
CAKI-1	IC₅₀	6.1 μM Compound: 1, NSC-622398	Antitumor activity against human Caki1 cells Antitumor activity against human Caki1 cells	[PMID: 15165138]
CCRF-CEM	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human CCRF-CEM cells Antitumor activity against human CCRF-CEM cells	[PMID: 15165138]
COLO 205	IC₅₀	1.2 μM Compound: 1, NSC-622398	Antitumor activity against human COLO205 cells Antitumor activity against human COLO205 cells	[PMID: 15165138]
Calu-1	IC₅₀	1.3 μM Compound: 2	Growth inhibition of p53 null, pRb+ human Calu1 cells after 48 hrs by MTT assay Growth inhibition of p53 null, pRb+ human Calu1 cells after 48 hrs by MTT assay	[PMID: 25368960]
DU-145	IC₅₀	4.9 μM Compound: 1, NSC-622398	Antitumor activity against human DU145 cells Antitumor activity against human DU145 cells	[PMID: 15165138]
EKVX	IC₅₀	5.1 μM Compound: 1, NSC-622398	Antitumor activity against human EKVX cells Antitumor activity against human EKVX cells	[PMID: 15165138]
HCC 2998	IC₅₀	1.7 μM Compound: 1, NSC-622398	Antitumor activity against human HCC2998 cells Antitumor activity against human HCC2998 cells	[PMID: 15165138]
HCT-116	IC₅₀	0.6 μM Compound: 1, NSC-622398	Antitumor activity against human HCT116 cells Antitumor activity against human HCT116 cells	[PMID: 15165138]
HCT-15	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human HCT15 cells Antitumor activity against human HCT15 cells	[PMID: 15165138]
HL-60(TB)	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human HL-60(TB) cells Antitumor activity against human HL-60(TB) cells	[PMID: 15165138]
HOP-62	IC₅₀	4.7 μM Compound: 1, NSC-622398	Antitumor activity against human HOP62 cells Antitumor activity against human HOP62 cells	[PMID: 15165138]
HT-29	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human HT-29 cells Antitumor activity against human HT-29 cells	[PMID: 15165138]
Hs-578T	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human Hs 578T cells Antitumor activity against human Hs 578T cells	[PMID: 15165138]
Huh-7	CC₅₀	0.589 μM Compound: GNF-Pf-1458	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	[PMID: 18579783]
IGROV-1	IC₅₀	4.5 μM Compound: 1, NSC-622398	Antitumor activity against human IGROV1 cells Antitumor activity against human IGROV1 cells	[PMID: 15165138]
K562	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human K562 cells Antitumor activity against human K562 cells	[PMID: 15165138]
KM12	IC₅₀	4.6 μM Compound: 1, NSC-622398	Antitumor activity against human KM12 cells Antitumor activity against human KM12 cells	[PMID: 15165138]
LOX IMVI	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human LOXIMVI cells Antitumor activity against human LOXIMVI cells	[PMID: 15165138]
LS174T	IC₅₀	0.88 μM Compound: 2	Growth inhibition of p53+, pRb+ human LS 174T cells after 48 hrs by MTT assay Growth inhibition of p53+, pRb+ human LS 174T cells after 48 hrs by MTT assay	[PMID: 25368960]
M14	IC₅₀	0.92 μM Compound: 1, NSC-622398	Antitumor activity against human M14 cells Antitumor activity against human M14 cells	[PMID: 15165138]
MCF7	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against ADF-resistant human MCF7 cells Antitumor activity against ADF-resistant human MCF7 cells	[PMID: 15165138]
MCF7	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human MCF7 cells Antitumor activity against human MCF7 cells	[PMID: 15165138]
MDA-MB-231	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human MDA-MB-231 cells Antitumor activity against human MDA-MB-231 cells	[PMID: 15165138]
MDA-MB-435	IC₅₀	0.56 μM Compound: 1, NSC-622398	Antitumor activity against human MDA-MB-435 cells Antitumor activity against human MDA-MB-435 cells	[PMID: 15165138]
MDA-N	IC₅₀	0.56 μM Compound: 1, NSC-622398	Antitumor activity against human MDA-N cells Antitumor activity against human MDA-N cells	[PMID: 15165138]
MOLT-4	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human MOLT4 cells Antitumor activity against human MOLT4 cells	[PMID: 15165138]
Malme-3M	IC₅₀	0.36 μM Compound: 1, NSC-622398	Antitumor activity against human MALME-3M cells Antitumor activity against human MALME-3M cells	[PMID: 15165138]
NCI-H226	IC₅₀	9.6 μM Compound: 1, NSC-622398	Antitumor activity against human NCI-H226 cells Antitumor activity against human NCI-H226 cells	[PMID: 15165138]
NCI-H23	IC₅₀	4.5 μM Compound: 1, NSC-622398	Antitumor activity against human NCI-H23 cells Antitumor activity against human NCI-H23 cells	[PMID: 15165138]
NCI-H322M	IC₅₀	5 μM Compound: 1, NSC-622398	Antitumor activity against human NCI-H322M cells Antitumor activity against human NCI-H322M cells	[PMID: 15165138]
NCI-H460	IC₅₀	4.2 μM Compound: 1, NSC-622398	Antitumor activity against human NCI-H460 cells Antitumor activity against human NCI-H460 cells	[PMID: 15165138]
NCI-H522	IC₅₀	4.5 μM Compound: 1, NSC-622398	Antitumor activity against human NCI-H522 cells Antitumor activity against human NCI-H522 cells	[PMID: 15165138]
OVCAR-3	IC₅₀	1.5 μM Compound: 1, NSC-622398	Antitumor activity against human OVCAR-3 cells Antitumor activity against human OVCAR-3 cells	[PMID: 15165138]
OVCAR-4	IC₅₀	5.3 μM Compound: 1, NSC-622398	Antitumor activity against human OVCAR4 cells Antitumor activity against human OVCAR4 cells	[PMID: 15165138]
OVCAR-5	IC₅₀	4.4 μM Compound: 1, NSC-622398	Antitumor activity against human OVCAR5 cells Antitumor activity against human OVCAR5 cells	[PMID: 15165138]
OVCAR-8	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human OVCAR8 cells Antitumor activity against human OVCAR8 cells	[PMID: 15165138]
PC-3	IC₅₀	0.92 μM Compound: 2	Growth inhibition of p53 null,pRb+ human PC3 cells after 48 hrs by MTT assay Growth inhibition of p53 null,pRb+ human PC3 cells after 48 hrs by MTT assay	[PMID: 25368960]
PC-3	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human PC3 cells Antitumor activity against human PC3 cells	[PMID: 15165138]
RPMI-8226	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human RPMI8226 cells Antitumor activity against human RPMI8226 cells	[PMID: 15165138]
RXF 393	IC₅₀	3.5 μM Compound: 1, NSC-622398	Antitumor activity against human RXF393 cells Antitumor activity against human RXF393 cells	[PMID: 15165138]
SF-268	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human SF268 cells Antitumor activity against human SF268 cells	[PMID: 15165138]
SF-295	IC₅₀	3.9 μM Compound: 1, NSC-622398	Antitumor activity against human SF295 cells Antitumor activity against human SF295 cells	[PMID: 15165138]
SF-539	IC₅₀	4.2 μM Compound: 1, NSC-622398	Antitumor activity against human SF539 cells Antitumor activity against human SF539 cells	[PMID: 15165138]
SK-MEL-28	IC₅₀	9.3 μM Compound: 1, NSC-622398	Antitumor activity against human SK-MEL-28 cells Antitumor activity against human SK-MEL-28 cells	[PMID: 15165138]
SK-MEL-5	IC₅₀	2 μM Compound: 1, NSC-622398	Antitumor activity against human SK-MEL-5 cells Antitumor activity against human SK-MEL-5 cells	[PMID: 15165138]
SK-OV-3	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human SKOV3 cells Antitumor activity against human SKOV3 cells	[PMID: 15165138]
SN12C	IC₅₀	4.2 μM Compound: 1, NSC-622398	Antitumor activity against human SN12C cells Antitumor activity against human SN12C cells	[PMID: 15165138]
SNB-19	IC₅₀	6.1 μM Compound: 1, NSC-622398	Antitumor activity against human SNB19 cells Antitumor activity against human SNB19 cells	[PMID: 15165138]
SNB-75	IC₅₀	5.4 μM Compound: 1, NSC-622398	Antitumor activity against human SNB75 cells Antitumor activity against human SNB75 cells	[PMID: 15165138]
SR	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human SR cells Antitumor activity against human SR cells	[PMID: 15165138]
SW-620	IC₅₀	3.7 μM Compound: 1, NSC-622398	Antitumor activity against human SW620 cells Antitumor activity against human SW620 cells	[PMID: 15165138]
Sf9	IC₅₀	0.35 μM Compound: Fascaplysin	Inhibition of CDK4/Cyclin D (unknown origin) expressed in baculovirus infected insect Sf9 cells using human pRB as substrate in presence of [gamma-32P]ATP Inhibition of CDK4/Cyclin D (unknown origin) expressed in baculovirus infected insect Sf9 cells using human pRB as substrate in presence of [gamma-32P]ATP	[PMID: 26741853]
Sf9	IC₅₀	0.55 μM Compound: 1	Inhibition of human CDK4/GST-cyclin D1 expressed in Sf9 cells assessed as retinoblastoma GST-RB152 phosphorylation Inhibition of human CDK4/GST-cyclin D1 expressed in Sf9 cells assessed as retinoblastoma GST-RB152 phosphorylation	[PMID: 18650093]
Sf9	IC₅₀	0.55 μM Compound: 4	Inhibition of human CDK4/ Cyclin D1 catalytic subunit expressed in Sf9 insect cells assessed as GST-RB152 fusion protein phosphorylation-associated depletion in ATP level by luminescence assay Inhibition of human CDK4/ Cyclin D1 catalytic subunit expressed in Sf9 insect cells assessed as GST-RB152 fusion protein phosphorylation-associated depletion in ATP level by luminescence assay	[PMID: 19632122]
Sf9	IC₅₀	500 μM Compound: 1	Inhibition of human CDK2/GST-cyclin A expressed in Sf9 cells assessed as histone phosphorylation Inhibition of human CDK2/GST-cyclin A expressed in Sf9 cells assessed as histone phosphorylation	[PMID: 18650093]
Sf9	IC₅₀	500 μM Compound: 4	Inhibition of human CDK2/ Cyclin A catalytic subunit expressed in Sf9 insect cells assessed as histone H1 phosphorylation-associated depletion in ATP level by luminescence assay Inhibition of human CDK2/ Cyclin A catalytic subunit expressed in Sf9 insect cells assessed as histone H1 phosphorylation-associated depletion in ATP level by luminescence assay	[PMID: 19632122]
T47D	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human T47D cells Antitumor activity against human T47D cells	[PMID: 15165138]
TK-10	IC₅₀	5.4 μM Compound: 1, NSC-622398	Antitumor activity against human TK10 cells Antitumor activity against human TK10 cells	[PMID: 15165138]
U-251	IC₅₀	3.6 μM Compound: 1, NSC-622398	Antitumor activity against human U251 cells Antitumor activity against human U251 cells	[PMID: 15165138]
UACC-257	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human UACC257 cells Antitumor activity against human UACC257 cells	[PMID: 15165138]
UACC-62	IC₅₀	4.9 μM Compound: 1, NSC-622398	Antitumor activity against human UACC62 cells Antitumor activity against human UACC62 cells	[PMID: 15165138]
UO-31	IC₅₀	> 10 μM Compound: 1, NSC-622398	Antitumor activity against human UO31 cells Antitumor activity against human UO31 cells	[PMID: 15165138]

In Vitro

Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs)^[2].
Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity^[2].
. Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo^[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

306.75

Formula

C₁₈H₁₁ClN₂O

CAS No.

114719-57-2

Appearance

Solid

Color

Light yellow to brown

SMILES

O=C1C2=C3NC4=C(C=CC=C4)C3=CC=[N+]2C5=C1C=CC=C5.[Cl-]

Structure Classification

Initial Source

Animals

sponge

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 95.64%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (256 KB) RP-HPLC (225 KB) MS (57 KB)

Handling Instructions (2659 KB)

References

[1]. BenjaminPelcman, Gordon WGribble. Total synthesis of the marine sponge pigment fascaplysin. Tetrahedron Letters. 1990, 31(17):2381-2384.

[2]. Zhidkov ME, et al. Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues. Mar Drugs. 2019 Aug 25;17(9):496. [Content Brief]

Fascaplysin Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fascaplysin114719-57-2ApoptosisAutophagyReactive Oxygen Species (ROS)CDKCyclin dependent kinaseS180 cellHL-60 cellsVascular endothelial cells (VECs)LeukemiaAnti-tumor activityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Fascaplysin

Customer Review

Fascaplysin Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All CDK Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Fascaplysin Related Antibodies

Fascaplysin Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report