2. Apoptosis Autophagy Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Cell Cycle/DNA Damage
  3. Apoptosis Autophagy Reactive Oxygen Species CDK
  4. Fascaplysin

Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity.

For research use only. We do not sell to patients.

Fascaplysin Chemical Structure

Fascaplysin Chemical Structure

CAS No. : 114719-57-2

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Fascaplysin Related Antibodies

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Description

Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2].

IC50 & Target

CDK4

 

In Vitro

Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs)[2].
Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity[2].
. Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fascaplysin Related Antibodies
In Vivo

Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

306.75

Formula

C18H11ClN2O
CAS No.
SMILES

O=C1C2=C3NC4=C(C=CC=C4)C3=CC=[N+]2C5=C1C=CC=C5.[Cl-]
Structure Classification
Initial Source

sponge
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fascaplysin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fascaplysin114719-57-2ApoptosisAutophagyReactive Oxygen SpeciesCDKCyclin dependent kinaseS180 cellHL-60 cellsVascular endothelial cells (VECs)LeukemiaAnti-tumor activityInhibitorinhibitorinhibit

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