2. Anti-infection
  3. Fungal
  4. Stellettamide A TFA

Stellettamide A TFA is a marine toxin found in a marine sponge. Stellettamide A TFA is a calmodulin inhibitor. Stellettamide A TFA can inhibit Ca2+/Mg2+ ATPase, phosphodiesterase, myosin light chain , and Mg2+-ATPase. Stellettamide A TFA inhibits high K+- and Ca2+-induced contraction in permeabilized smooth muscle. Stellettamide A TFA exhibits antifungal activity against Mortierella remannianus. Stellettamide A TFA can be used for the research of fungal infection.

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Stellettamide A TFA

Stellettamide A TFA Chemical Structure

CAS No. : 129744-24-7

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Stellettamide A TFA Related Antibodies

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Description

Stellettamide A TFA is a marine toxin found in a marine sponge. Stellettamide A TFA is a calmodulin inhibitor. Stellettamide A TFA can inhibit Ca2+/Mg2+ ATPase, phosphodiesterase, myosin light chain , and Mg2+-ATPase. Stellettamide A TFA inhibits high K+- and Ca2+-induced contraction in permeabilized smooth muscle. Stellettamide A TFA exhibits antifungal activity against Mortierella remannianus. Stellettamide A TFA can be used for the research of fungal infection[1].

In Vitro

Stellettamide A TFA (3-300 μM; 1 h) inhibits Ca2+-stimulated Mg2+-ATPase activity in native actomyosin from chicken gizzard with an IC50 of 25 μM[1].
Stellettamide A TFA (3-300 μM) inhibits myosin light chain phosphorylation in a reconstituted smooth muscle contractile system with an IC50 of 152 μM, and this effect is antagonized by higher calmodulin concentrations[1].
Stellettamide A TFA (3-300 μM) inhibits Ca2+/calmodulin-dependent (Ca2+-Mg2+)-ATPase from rabbit erythrocyte membranes (IC50 = 100 μM) and phosphodiesterase from bovine heart (IC50 = 52 μM), with the latter effect antagonized by higher calmodulin concentrations[1].
Stellettamide A TFA (3-300 μM) quenches calmodulin’s intrinsic tyrosine fluorescence in a concentration-dependent manner with or without Ca2+, indicating direct binding independent of Ca2+[1].
Stellettamide A TFA inhibits high
K+(72.7 mM), Ca2+(3 mM and 10 mM)-induced contraction in the smooth muscle of guinea-pig taenia coli with an IC50 of 88, 46 and 105 mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Stellettamide A TFA Related Antibodies
Molecular Weight

515.67

Formula

C28H46F3N2O3+
CAS No.
SMILES

OC(C(F)(F)F)=O.C[N@@+]12[C@@](CCCC2)([H])[C@@H](CC1)CNC(/C=C/[C@@H](C)CC/C=C(C)/CC/C=C(C)/C)=O
Structure Classification
Initial Source

marine sponge
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Stellettamide A TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stellettamide A129744-24-7ST-AFungalbovine cardiac muscle phosphodiesterasechicken gizzard native actomyosin Mg2?-ATPaseCa2?/calmodulin-dependent enzyme activitiesMLC phosphorylationchicken myosin light chain kinasecalmodulinMortierella remannianussmooth muscle contractionrabbit erythrocyte membrane Ca2?/Mg2? ATPaseepithelium cellsInhibitorinhibitorinhibit

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