1. Epigenetics PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK
  2. AMPK VEGFR PDGFR
  3. 10Z-Hymenialdisine

10Z-Hymenialdisine  (Synonyms: (Z)-Hymenialdisine; Hymenialdisine)

Cat. No.: HY-N6794
COA Handling Instructions

10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities.

For research use only. We do not sell to patients.

10Z-Hymenialdisine Chemical Structure

10Z-Hymenialdisine Chemical Structure

CAS No. : 82005-12-7

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Description

10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities[1].

In Vitro

10Z-Hymenialdisine displays a moderate effect on (ARK5, VEGFR-2, SAK and PDGFR) protein kinases. 10Z-Hymenialdisine shows a potent inhibition of RAF/MEK-1/MAPK cascade with an IC50 value of 6 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

324.13

Formula

C11H10BrN5O2

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C2=C(C=C(N2)Br)/C(CCN1)=C3C(N=C(N/3)N)=O

Structure Classification
Initial Source

marine sponge Axinella carteri

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥97.0%

References
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10Z-Hymenialdisine Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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