10Z-Hymenialdisine
Based on 1 publication(s) in Google Scholar
10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 82005-12-7
- Fòrmula: C11H10BrN5O2
- Peso molecular:324.13
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Publications Citing Use of MedChemExpress (MCE) 10Z-Hymenialdisine
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
>7799 nM
Compound: 5
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Inhibition of human adenocarcinoma cell line Caco-2 proliferation
Inhibition of human adenocarcinoma cell line Caco-2 proliferation
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[PMID: 11784156] |
| CCRF-CEM | GI50 |
1.61 μM
Compound: 1 (Hymenialdisine)
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Inhibition of cell growth in CEM leukemia T cells was determined
Inhibition of cell growth in CEM leukemia T cells was determined
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[PMID: 15214798] |
| Jurkat | IC50 |
2.41 μM
Compound: 1 (Hymenialdisine)
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Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay
Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay
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[PMID: 15214798] |
| Jurkat | IC50 |
4 μM
Compound: 8; 55, 63
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Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay
Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay
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[PMID: 36496202] |
| KB 3-1 | IC50 |
3.1 μM
Compound: HMD; 1a
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Cytotoxicity against human KB-3-1 cells by MTT assay
Cytotoxicity against human KB-3-1 cells by MTT assay
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[PMID: 33901899] |
| L5178Y | EC50 |
3.5 μg/mL
Compound: HMD; 1a
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Cytotoxicity against mouse L5178Y cells by MTT assay
Cytotoxicity against mouse L5178Y cells by MTT assay
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[PMID: 33901899] |
| LoVo | IC50 |
6 nM
Compound: 8; 55, 63
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Inhibition of cell growth in human LoVo cells by SRB assay
Inhibition of cell growth in human LoVo cells by SRB assay
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[PMID: 36496202] |
| LoVo | IC50 |
710 nM
Compound: 5
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Inhibition of human adenocarcinoma cell line LoVo proliferation
Inhibition of human adenocarcinoma cell line LoVo proliferation
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[PMID: 11784156] |
| MONO-MAC-6 | IC50 |
0.2 μg/mL
Compound: 6
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Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs
Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs
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[PMID: 9917317] |
| MONO-MAC-6 | IC50 |
0.61 μM
Compound: 8; 55, 63
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Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis
Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis
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[PMID: 36496202] |
| SW-620 | IC50 |
2 μM
Compound: HMD; 1a
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Cytotoxicity against human SW620 cells by MTT assay
Cytotoxicity against human SW620 cells by MTT assay
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[PMID: 33901899] |
| THP-1 | IC50 |
1.36 μM
Compound: 1 (Hymenialdisine)
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Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay
Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay
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[PMID: 15214798] |
| THP-1 | IC50 |
1.4 μM
Compound: 8; 55, 63
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Antiinflammatory activity in LPS induced human THP-1 cells assessed as inhibition of TNF-alpha production by EIA assay
Antiinflammatory activity in LPS induced human THP-1 cells assessed as inhibition of TNF-alpha production by EIA assay
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[PMID: 36496202] |
| THP-1 | IC50 |
1.4 μM
Compound: HMD; 1a
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Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated TNFalpha production
Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated TNFalpha production
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[PMID: 33901899] |
| THP-1 | IC50 |
2.4 μM
Compound: HMD; 1a
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Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated IL2 production
Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated IL2 production
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[PMID: 33901899] |
In Vitro
10Z-Hymenialdisine displays a moderate effect on (ARK5, VEGFR-2, SAK and PDGFR) protein kinases. 10Z-Hymenialdisine shows a potent inhibition of RAF/MEK-1/MAPK cascade with an IC50 value of 6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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No. CAS 82005-12-7
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Appearance Solid
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Peso molecular 324.13
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Fòrmula C11H10BrN5O2
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Color White to light yellow
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SMILES
O=C1C2=C(C=C(N2)Br)/C(CCN1)=C3C(N=C(N/3)N)=O
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Synonyms
(Z)-Hymenialdisine; Hymenialdisine
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
In Vitro:
DMSO : 3.24 mg/mL (10.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0852 mL | 15.4259 mL | 30.8518 mL | 77.1295 mL |
| 5 mM | 0.6170 mL | 3.0852 mL | 6.1704 mL | 15.4259 mL |
10Z-Hymenialdisine Related Classifications
HY-N6794 Related Classifications
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