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Cat. No.: HY-N6794

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10Z-Hymenialdisine

(Synonyms: (Z)-Hymenialdisine; Hymenialdisine)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities.

For research use only. We do not sell to patients.

CAS No.: 82005-12-7
Formula: C₁₁H₁₀BrN₅O₂
Molecular Weight:324.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

10Z-Hymenialdisine Chemical Structure

CAS No.: 82005-12-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities^[1].

All AMPK Isoforms :

All VEGFR Isoforms :

All PDGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	>7799 nM Compound: 5	Inhibition of human adenocarcinoma cell line Caco-2 proliferation Inhibition of human adenocarcinoma cell line Caco-2 proliferation	[PMID: 11784156]
CCRF-CEM	GI₅₀	1.61 μM Compound: 1 (Hymenialdisine)	Inhibition of cell growth in CEM leukemia T cells was determined Inhibition of cell growth in CEM leukemia T cells was determined	[PMID: 15214798]
Jurkat	IC₅₀	2.41 μM Compound: 1 (Hymenialdisine)	Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay	[PMID: 15214798]
Jurkat	IC₅₀	4 μM Compound: 8; 55, 63	Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay	[PMID: 36496202]
KB 3-1	IC₅₀	3.1 μM Compound: HMD; 1a	Cytotoxicity against human KB-3-1 cells by MTT assay Cytotoxicity against human KB-3-1 cells by MTT assay	[PMID: 33901899]
L5178Y	EC₅₀	3.5 μg/mL Compound: HMD; 1a	Cytotoxicity against mouse L5178Y cells by MTT assay Cytotoxicity against mouse L5178Y cells by MTT assay	[PMID: 33901899]
LoVo	IC₅₀	6 nM Compound: 8; 55, 63	Inhibition of cell growth in human LoVo cells by SRB assay Inhibition of cell growth in human LoVo cells by SRB assay	[PMID: 36496202]
LoVo	IC₅₀	710 nM Compound: 5	Inhibition of human adenocarcinoma cell line LoVo proliferation Inhibition of human adenocarcinoma cell line LoVo proliferation	[PMID: 11784156]
MONO-MAC-6	IC₅₀	0.2 μg/mL Compound: 6	Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs	[PMID: 9917317]
MONO-MAC-6	IC₅₀	0.61 μM Compound: 8; 55, 63	Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis	[PMID: 36496202]
SW-620	IC₅₀	2 μM Compound: HMD; 1a	Cytotoxicity against human SW620 cells by MTT assay Cytotoxicity against human SW620 cells by MTT assay	[PMID: 33901899]
THP-1	IC₅₀	1.36 μM Compound: 1 (Hymenialdisine)	Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay	[PMID: 15214798]
THP-1	IC₅₀	1.4 μM Compound: 8; 55, 63	Antiinflammatory activity in LPS induced human THP-1 cells assessed as inhibition of TNF-alpha production by EIA assay Antiinflammatory activity in LPS induced human THP-1 cells assessed as inhibition of TNF-alpha production by EIA assay	[PMID: 36496202]
THP-1	IC₅₀	1.4 μM Compound: HMD; 1a	Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated TNFalpha production Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated TNFalpha production	[PMID: 33901899]
THP-1	IC₅₀	2.4 μM Compound: HMD; 1a	Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated IL2 production Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated IL2 production	[PMID: 33901899]

In Vitro

10Z-Hymenialdisine displays a moderate effect on (ARK5, VEGFR-2, SAK and PDGFR) protein kinases. 10Z-Hymenialdisine shows a potent inhibition of RAF/MEK-1/MAPK cascade with an IC₅₀ value of 6 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 82005-12-7
Appearance Solid
Molecular Weight 324.13
Formula C₁₁H₁₀BrN₅O₂
Color White to light yellow
SMILES

O=C1C2=C(C=C(N2)Br)/C(CCN1)=C3C(N=C(N/3)N)=O
Synonyms

(Z)-Hymenialdisine; Hymenialdisine
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
- Marine natural products
- Sponge
- Animals
marine sponge Axinella carteri
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

bioRxiv

2026 Feb 25.

Solvent & Solubility

In Vitro:

DMSO : 3.24 mg/mL (10.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0852 mL

15.4259 mL

30.8518 mL

5 mM

0.6170 mL

3.0852 mL

6.1704 mL

10 mM

0.3085 mL

1.5426 mL

3.0852 mL

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ashraf N E Hamed, et al. Bioactive pyrrole alkaloids isolated from the Red Sea: marine sponge Stylissa carteri. Z Naturforsch C J Biosci. 2018 Apr 25;73(5-6):199-210. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0852 mL	15.4259 mL	30.8518 mL	77.1295 mL
DMSO	5 mM	0.6170 mL	3.0852 mL	6.1704 mL	15.4259 mL

Keywords

10Z-Hymenialdisine

1 Cited Publications

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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10Z-Hymenialdisine

Publications Citing Use of MedChemExpress (MCE) 10Z-Hymenialdisine

All AMPK Isoforms

All VEGFR Isoforms

All PDGFR Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

10Z-Hymenialdisine Related Classifications

HY-N6794 Related Classifications