Physcion (Synonyms: Parietin; Rheochrysidin)

Name: Physcion
Brand: MedChemExpress
SKU: HY-N0108
Rating: 5.0 (8 reviews)

Cat. No.: HY-N0108 Purity: 99.40%: Data Sheet
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Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC₅₀ and K_d values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells.

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CAS No. : 521-61-9

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 8 publication(s) in Google Scholar

Other Forms of Physcion:

Physcion-d₃ In-stock
Physcion (Standard) 견적 받기

8 Publications Citing Use of MCE Physcion

Cell Proliferation/Viability Assay

Flow Cytometry

In Vivo Efficacy Study

: Physcion purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 26;24(1):97. [Abstract]; The cell viability of KYSE-30 and KYSE-410 cells was evaluated after treatment with various concentrations of Physcion (20, 40, 60, 80 μM) for 24 to 72 h.

: Physcion purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 26;24(1):97. [Abstract]; Intracellular ROS levels in ESCC cells fluctuated after 48 h of Physcion (20, 40 μM) treatment.

: Physcion purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 26;24(1):97. [Abstract]; Western blot analysis revealed a reduction in CDK2 protein expression in ESCC cells following Physcion (20, 40 μM) treatment.

: Physcion purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 26;24(1):97. [Abstract]; The effect of Physcion (20, 40 μM) on DNA synthesis in ESCC cells was detected using an EdU staining assay.

: Physcion purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 26;24(1):97. [Abstract]; Effects of physcion combined with metformin on the growth of ESCC in vivo. The changes in body weight and tumor volume in nude mice after administration of Physcion (20 mg/kg) and Metformin (200 mg/kg) as single drugs or in combination.

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

TLR4

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.5 μM Compound: 80	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay	[PMID: 33691166]
A549	IC₅₀	> 100 μg/mL Compound: 6	Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26995526]
HCT-116	IC₅₀	19 μM Compound: 2	Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay	[PMID: 17949858]
HT-29	IC₅₀	> 100 μg/mL Compound: 6	Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26995526]
HUVEC	IC₅₀	> 100 μg/mL Compound: 6	Antiproliferative activity against human HUVEC cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HUVEC cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26995526]
HepG2	IC₅₀	77.3 μM Compound: 2	Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay	[PMID: 17949858]
HepG2 2.2.15	IC₅₀	300 μg/mL Compound: 53	Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV DNA production Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV DNA production	[PMID: 24549242]
HepG2 2.2.15	IC₅₀	300 μg/mL Compound: 53	Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV e antigen secretion Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV e antigen secretion	[PMID: 24549242]
HepG2 2.2.15	IC₅₀	300 μg/mL Compound: 53	Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV surface antigen secretion Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV surface antigen secretion	[PMID: 24549242]
KB	ED₅₀	1.55 μg/mL Compound: 2	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	10.1021/np50085a021
MCF7	IC₅₀	> 100 μg/mL Compound: 6	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26995526]
NCI-H157	IC₅₀	3 μM Compound: 80	Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay	[PMID: 33691166]
PLC-PRF-5	ED₅₀	1.44 μg/mL Compound: 2	Cytotoxicity against human PLC/PRF/5 cells Cytotoxicity against human PLC/PRF/5 cells	10.1021/np50085a021

In Vitro

Physcion (10 or 20 μM, 48 h) induces apoptosis and autophagy in human nasopharyngeal carcinoma (CNE2 cells)^[2].
Physcion (10-40 μM, 24 h) attenuates OGD/R (oxygen-glucose deprivation/reperfusion)-induced neuronal damage and inflammatory response in SH-SY5Y cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:	The nasopharyngeal carcinoma cell line CNE2
Concentration:	10 or 20 μM
Incubation Time:	48 h
Result:	Induced apoptosis in CNE2 cells in a dose-dependent manner.

Western Blot Analysis^[2]

Cell Line:	The nasopharyngeal carcinoma cell line CNE2
Concentration:	10 or 20 μM
Incubation Time:	48 h
Result:	Significantly increased the level of LC3B-II, which means physcion induced autophagy in CNE2 cells.

Western Blot Analysis^[3]

Cell Line:	Oxygen-glucose deprivation/reperfusion (OGD/R)-induced SH-SY5Y cells
Concentration:	40 μM
Incubation Time:	24 h
Result:	Significantly reversed the OGD/R-induced upregulation of TLR4, p-p65, and p-IκB expression.

In Vivo

Physcion (20 or 40 mg/kg, p.o., once daily for 7 days) exerts neuroprotective effects by inhibiting the TLR4/NF-κB signaling pathway in an ischemia-reperfusion-induced SD rat model^[3].
Physcion (4 or 9 mg/kg, p.o., once daily for 6 days) effectively alleviates infection symptoms caused by Chlamydia psittaci 6 BCE in SPF chickens^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Ischemia-reperfusion (I/R)-induced focal cerebral ischemia model in SD rats^[3]
Dosage:	20 or 40 mg/kg
Administration:	Oral gavage (p.o.), once daily for 7 days
Result:	Significantly reduced the brain water content and the NSS (Neurological Severity Score) in I/R rats, compared to I/R group. Obviously decreased areas of infarction compared to I/R group.

Animal Model:	SPF chickens (21 days old) infected intra-laryngeally with Chlamydia psittaci 6 BCE^[4]
Dosage:	4 or 9 mg/kg
Administration:	Oral gavage (p.o.), once daily for 6 days
Result:	Dose-dependently alleviated respiratory distress, air sac and lung lesions, and bacterial load in the spleen in infected chickens.

분자량

284.26

화학식

C₁₆H₁₂O₅

CAS No.

521-61-9

Appearance

Solid

Color

Yellow to orange

SMILES

O=C1C2=C(C=C(C)C=C2O)C(C3=CC(OC)=CC(O)=C13)=O

Structure Classification

Initial Source

Microorganisms

Microsporum sp;Teloschistes flavicans

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

THF : 2.5 mg/mL (8.79 mM; ultrasonic and warming and heat to 60°C)

DMF : 1 mg/mL (3.52 mM; Need ultrasonic)

Ethanol : < 1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5179 mL	17.5895 mL	35.1791 mL
5 mM	0.7036 mL	3.5179 mL	7.0358 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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순도&문서

Purity: 99.40%

Select Batch:

Data Sheet (281 KB) SDS (393 KB)

COA (250 KB) HNMR (243 KB) RP-HPLC (244 KB) MS (229 KB)

Handling Instructions (2659 KB)

References

[1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. [Content Brief]

[2]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640. [Content Brief]

[3]. Dong X, et al. Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway. Drug Des Devel Ther. 2021 Jan 25;15:277-287. [Content Brief]

[4]. Liu X, et al. Physcion, a novel anthraquinone derivative against Chlamydia psittaci infection. Vet Microbiol. 2023 Apr;279:109664. doi: 10.1016/j.vetmic.2023.109664. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF / THF	1 mM	3.5179 mL	17.5895 mL	35.1791 mL	87.9477 mL
THF	5 mM	0.7036 mL	3.5179 mL	7.0358 mL	17.5895 mL

Physcion Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Physcion (Synonyms: Parietin; Rheochrysidin)

고객리뷰

Other Forms of Physcion:

Physcion Related Antibodies

8 Publications Citing Use of MCE Physcion

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Toll-like Receptor (TLR) Isoform Specific Products:

View All NF-κB Isoform Specific Products:

View All Antibiotic Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Physcion Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Physcion Related Classifications

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Request for HNMR Report

SAFETY DATA SHEET (SDS)

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