2. Anti-infection
  3. Antibiotic Bacterial
  4. Polymyxin B Sulfate

Polymyxin B (Sulfate)  (Synonyms: ポリミキシンB硫酸塩)

製品番号: HY-A0248 純度: 96.88%
COA 取扱説明書 Technical Support

Polymyxin B Sulfate is an antibiotic. Polymyxin B Sulfate inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B Sulfate neutralizes the effect of endotoxin. Polymyxin B Sulfate induces bacterial death by increasing its permeability. Polymyxin B Sulfate is used in endotoxemia research.

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CAS 番号 : 1405-20-5

容量 価格（税別） 在庫状況 数量
500 mg $35 在庫あり
1 g $52 在庫あり
5 g $190 在庫あり
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Based on 23 publication(s) in Google Scholar

Other Forms of Polymyxin B Sulfate:

Polymyxin B (Sulfate) 関連抗体

Top Publications Citing Use of Products

    Polymyxin B Sulfate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465.  [Abstract]

    Electrophoretic migration of Td and the Polymyxin B@Td nanocomplex at different gradient mixture ratios (Polymyxin B: Td = 10:1, 50:1, and 100:1).

    Polymyxin B Sulfate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465.  [Abstract]

    Analysis of the zeta potentials of Polymyxin B, Td, and the Polymyxin B@Td nanocomplex.

    Polymyxin B Sulfate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465.  [Abstract]

    Penetration of free or Td-bound Polymyxin B into a bacterial biofilm, as characterized by CLSM (blue: Hoechst33342-stained bacteria; green: FITC-labeled Td; red: Cy5-labeled Polymyxin B). Scale bar: 50 μm.

    Polymyxin B Sulfate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465.  [Abstract]

    SEM analysis of biofilm structural disruption by Polymyxin B and Polymyxin B@Td. Red arrows: biofilm matrix components. Red dotted-line square: representative dead bacteria. Scale bar: 5–3 μm.

    Polymyxin B Sulfate purchased from MedChemExpress. Usage Cited in: J Control Release. 2025 May 30:113907.  [Abstract]

    Antimicrobial effects of PMB-LNPs. MIC and Polymyxin B values of Polymyxin B -LNPs or free Polymyxin B against E. coli, A. baumannii.

    Polymyxin B Sulfate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    The cytotoxicity assessment of PEG-pHSA@PMB nanoparticles. The toxicity of Polymyxin B Sulfate (PMB, 24 h), PEG-pHSA@PMB, and PEG-pHSA to HBE cells was detected by the CCK-8 kit.

    Polymyxin B Sulfate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    Polymyxin B Sulfate, 4 μg/mL. The bacteriostasis curves of the drugs. The OD600 value of the CRKP suspension was determined at different times.

    Polymyxin B Sulfate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    The load of CRKP in the lungs of mice that inhaled different drugs. The bacterial load of CRKP in the lungs of pneumonia mice treated with inhaled drugs (equivalent to 4 mg/kg loaded Polymyxin B Sulfate) was measured by the bacterial plate counting method.

    Polymyxin B Sulfate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    PEG-pHSA@PMB (4 mg/kg loaded Polymyxin B Sulfate). HE staining of lung sections of CRKP pneumonia mice treated with different drugs. The scale bar is 50 μm.

    Polymyxin B Sulfate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    PEG-pHSA@PMB (4 mg/kg loaded Polymyxin B Sulfate). The statistical chart of lung injury score by HE staining of lung tissue in each group, n = 9.

    Polymyxin B Sulfate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.

    HE staining of different tissues in mice treated with different drugs. The HE staining results of the lungs, kidneys, brains, hearts, livers, and spleens of ICR mice were examined after inhaling 30 μL of different drugs (equivalent to 8 mg/kg loaded Polymyxin B Sulfate) three times daily for 3 days, n = 5. The scale bar is 100 μm.

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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    製品説明

    Polymyxin B Sulfate is an antibiotic. Polymyxin B Sulfate inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B Sulfate neutralizes the effect of endotoxin. Polymyxin B Sulfate induces bacterial death by increasing its permeability. Polymyxin B Sulfate is used in endotoxemia research[1][2][3][4].

    体外実験

    Polymyxin B (10 μg/mL, 6 h) Sulfate decreases the TNF-α and IL-10 production in Human peripheral blood mononuclear cells (PBMC) [3].
    Polymyxin B Sulfate shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Polymyxin B (Sulfate) 関連抗体
    体内実験

    Polymyxin B (0.5-120 mg/kg; s.c.) Sulfate shows antibacterial activities in thigh or lung infection mouse model[2].
    Polymyxin B (2 mg/kg, s.c.) Sulfate shows potent in mouse bactericidal effect against E. coli strain IH3080[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Eight-week-old, 24-30 g, female Swiss mice[2]
    Dosage: 0.5-120 mg/kg for thigh infection model; 5-120 mg/kg for lung infection model
    Administration: S.c.
    Result: Showed antibacterial activities for three K. pneumoniae strains.
    Animal Model: 7-9 weeks, female NMRI mice (E. coli IH3080)[3]
    Dosage: 2 mg/kg
    Administration: S.c.
    Result: Decreased the bacterial count in a dose dependent manner.
    分子量

    1199.75 (average)

    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    Structure Classification
    Initial Source

    Bacillus polymyxa
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 116.67 mg/mL (Need ultrasonic)

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    純度とドキュメンテーション

    純度: 96.88%

    COA (254 KB) RP-HPLC (261 KB)

    取扱説明書 (2659 KB)
    参考文献
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    Polymyxin B Sulfate Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Polymyxin B1405-20-5AntibioticBacterialantiendotoxinantibacterialantibioticE. coli strainInhibitorinhibitorinhibit

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    製品番号:
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