Polymyxin B nonapeptide

Name: Polymyxin B nonapeptide
Brand: MedChemExpress
SKU: HY-106783
Rating: 5.0 (2 reviews)

Cat. No.: HY-106783 Purity: 99.83%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

Polymyxin B nonapeptide 화학구조

CAS No. : 86408-36-8

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	견적 받기
200 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 2 publication(s) in Google Scholar

Other Forms of Polymyxin B nonapeptide:

Polymyxin B nonapeptide TFA In-stock
Polymyxin B nonapeptide (Standard) 견적 받기

2 Publications Citing Use of MCE Polymyxin B nonapeptide

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

Polymyxin B nonapeptide (2-32 μg/mL, 24 h) has a synergistic effect with Azithromycin (HY-17506)^[1].
Polymyxin B nonapeptide (10 μg/mL) inhibits  lipopolysaccharide (HY-D1056)-induced neutrophilic activation in a concentration-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	E. coli strains
Concentration:	2, 4, 8, 16, 32 μg/mL
Incubation Time:	24 h
Result:	Combinated with AZT caused a significant reduction the bacterial growth after 6 h and complete killing after 24 h.

In Vivo

Polymyxin B nonapeptide (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

963.13

화학식

C₄₃H₇₄N₁₄O₁₁

CAS No.

86408-36-8

Appearance

Solid

Color

White to off-white

Sequence

Thr-{Dab}-{Dab}-{Dab}-d-Phe-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9)

Sequence Shortening

T-{Dab}-{Dab}-{Dab}-d-FL-{Dab}-{Dab}-T (Lactam: Dab3-Thr9)

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

H₂O : ≥ 100 mg/mL (103.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0383 mL	5.1914 mL	10.3828 mL
5 mM	0.2077 mL	1.0383 mL	2.0766 mL
10 mM	0.1038 mL	0.5191 mL	1.0383 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.83%

Select Batch:

Data Sheet (285 KB) SDS (254 KB)

COA (263 KB) RP-HPLC (254 KB) MS (336 KB)

Handling Instructions (2659 KB)

References

[1]. Al-Marzooq F, et al. Discerning the role of polymyxin B nonapeptide in restoring the antibacterial activity of azithromycin against antibiotic-resistant Escherichia coli. Front Microbiol. 2022 Sep 21;13:998671. [Content Brief]

[2]. Danner RL,et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother. 1989 Sep;33(9):1428-34. [Content Brief]

[3]. Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.0383 mL	5.1914 mL	10.3828 mL	25.9570 mL
	5 mM	0.2077 mL	1.0383 mL	2.0766 mL	5.1914 mL
	10 mM	0.1038 mL	0.5191 mL	1.0383 mL	2.5957 mL
	15 mM	0.0692 mL	0.3461 mL	0.6922 mL	1.7305 mL
	20 mM	0.0519 mL	0.2596 mL	0.5191 mL	1.2979 mL
	25 mM	0.0415 mL	0.2077 mL	0.4153 mL	1.0383 mL
	30 mM	0.0346 mL	0.1730 mL	0.3461 mL	0.8652 mL
	40 mM	0.0260 mL	0.1298 mL	0.2596 mL	0.6489 mL
	50 mM	0.0208 mL	0.1038 mL	0.2077 mL	0.5191 mL
	60 mM	0.0173 mL	0.0865 mL	0.1730 mL	0.4326 mL
	80 mM	0.0130 mL	0.0649 mL	0.1298 mL	0.3245 mL
	100 mM	0.0104 mL	0.0519 mL	0.1038 mL	0.2596 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.