2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Tandospirone citrate

Tandospirone citrate  (Synonyms: SM-3997 citrate)

製品番号: HY-B0061 純度: 99.92%
COA 取扱説明書 Technical Support

Tandospirone (SM-3997) citrate is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone citrate has anxiolytic and antidepressant activities. Tandospirone citrate can be used for the research of the central nervous system disorders and the underlying mechanisms.

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Tandospirone citrate

Tandospirone citrate 構造式

CAS 番号 : 112457-95-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 76 在庫あり
Solution
10 mM * 1 mL in Water USD 76 在庫あり
Solid
5 mg $60 在庫あり
10 mg $95 在庫あり
25 mg $190 在庫あり
50 mg $300 在庫あり
100 mg $480 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 3 publication(s) in Google Scholar

Other Forms of Tandospirone citrate:

Tandospirone citrate 関連抗体

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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製品説明

Tandospirone (SM-3997) citrate is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone citrate has anxiolytic and antidepressant activities. Tandospirone citrate can be used for the research of the central nervous system disorders and the underlying mechanisms[1][2][3].

IC50 & Target

5-HT1A Receptor

 

体外実験

Tandospirone citrate is approximately two to three orders of magnitude less potent at 5-HT2, 5-HT1C, α1-adrenergic, α2-adrenergic and dopamine D1 and D2 receptors (Ki values ranging from 1300 to 41000 nM) than 5-HT1A[1].
Tandospirone citrate is essentially inactive at 5-HT1B receptors; 5-HT uptake sites; beta-adrenergic, muscarinic cholinergic, and benzodiazepine receptors[1].
Tandospirone citrate activates postsynaptic 5-HT1A receptor coupled with G-protein (Gi/o), resulting in inhibition of protein kinase A (PKA)-mediated protein phosphorylation and neuronal activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tandospirone citrate 関連抗体
体内実験

Tandospirone (10-80 mg/kg; i.p.) citrate inhibits freezing behavior in the conditioned fear stress-induced freezing behavior rat model[3].
Tandospirone citrate exhibits the anxiolytic effect dependent on the plasma concentration of at 0.5 hours but not 4 hours[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old male Sprague-Dawley rats (260-300 g), conditioned fear stress-induced freezing behavior rat model[3]
Dosage: 10 mg/kg, 20 mg/kg, 40 mg/kg, 80 mg/kg
Administration: Intraperitoneal injection
Result: Inhibited freezing behavior in a dose-dependent manner.
臨床実験
分子量

575.61

分子式

C27H37N5O9
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CCCCN2CCN(C3=NC=CC=N3)CC2)C([C@@]4([H])[C@](C5)([H])CC[C@]5([H])[C@@]14[H])=O.O=C(CC(C(O)=O)(O)CC(O)=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 29.17 mg/mL (50.68 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7373 mL 8.6864 mL 17.3729 mL
5 mM 0.3475 mL 1.7373 mL 3.4746 mL
10 mM 0.1737 mL 0.8686 mL 1.7373 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (43.43 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.92%

COA (254 KB) HNMR (299 KB) LCMS (96 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7373 mL 8.6864 mL 17.3729 mL 43.4322 mL
5 mM 0.3475 mL 1.7373 mL 3.4746 mL 8.6864 mL
10 mM 0.1737 mL 0.8686 mL 1.7373 mL 4.3432 mL
15 mM 0.1158 mL 0.5791 mL 1.1582 mL 2.8955 mL
20 mM 0.0869 mL 0.4343 mL 0.8686 mL 2.1716 mL
25 mM 0.0695 mL 0.3475 mL 0.6949 mL 1.7373 mL
30 mM 0.0579 mL 0.2895 mL 0.5791 mL 1.4477 mL
40 mM 0.0434 mL 0.2172 mL 0.4343 mL 1.0858 mL
50 mM 0.0347 mL 0.1737 mL 0.3475 mL 0.8686 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tandospirone citrate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tandospirone112457-95-1SM-3997SM3997SM 39975-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor6-5-hydroxytryptamineanxietydisorderdepressionParkinson's diseaseschizophreniacentralnervoussystemCNSdisordersInhibitorinhibitorinhibit

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製品名:
Tandospirone citrate
製品番号:
HY-B0061
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