2. Immunology/Inflammation GPCR/G Protein
  3. COX Prostaglandin Receptor
  4. Ufenamate

Ufenamate  (Synonyms: Flufenamic acid butyl ester; Butyl flufenamate)

Cat. No.: HY-100009 Purity: 99.89%
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Handling Instructions Technical Support

Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug that can be used in the study of skin diseases such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliary rashes and atopic dermatitis. Ufenamate has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging model, downregulates the expression level of COX-2 and can promote the healing of mouse skull defects by secreting BMP2.

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Ufenamate

Ufenamate 화학구조

CAS No. : 67330-25-0

사이즈 가격 재고 수량
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Liquid
50 mg 해외재고보유
100 mg 해외재고보유
250 mg 해외재고보유
500 mg 해외재고보유
1 g 해외재고보유
5 g   견적 받기  
10 g   견적 받기  

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고객리뷰

Based on 1 Customer Validation

Other Forms of Ufenamate:

Ufenamate Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

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제품 설명

Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug that can be used in the study of skin diseases such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliary rashes and atopic dermatitis. Ufenamate has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging model, downregulates the expression level of COX-2 and can promote the healing of mouse skull defects by secreting BMP2[1][2][3][4].

IC50 & Target

COX-2

 

In Vivo

Ufenamat (2 µL/cm2, ointment application, single dose) is not suitable for dry skin in rats[2].
Ufenamate (Ointment application, single dose) has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging mice model and downregulates the expression level of COX-2[3].
Ufenamat (Ointment application, 6 and 8 weeks) promotes the healing of skull injuries in mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UV-induced acute sunburn model, photoaging model and skin squamous cell carcinoma model in SKH-1 hairless mice[3]
Dosage: Ointment application
Administration: Ointment application; single dose; 30 min
Result: Inhibited acute swelling and redness caused by UV irradiation and reduced COX-2 expression.
At 12 weeks of irradiation, skin aging was alleviated, the collagen density of the dermis was higher, the expression of Bcl-2 was weakened, and the expression of Bax and Caspase 3 was enhanced.
At 28 weeks of irradiation, the appearance of tumors was delayed.
Animal Model: Intact and damaged skin of rats[2]
Dosage: 2µL/cm2
Administration: Ointment application; single dose
Result: Applied on the damaged skin, contained in the epidermis was approximately 50% and 25% of that in the intact skin after LP and water, respectively, with the content being 5 times and 10 times higher than in the intact skin.
Permeated UF five times more than LP in the intact skin. Reduced significantly the permeation of UF by both LP and water due to the defatting effect of SC.
Animal Model: Skull defect mice[4]
Dosage: Ointment application
Administration: Ointment application; 6 weeks and 8 weeks
Result: Promoted the formation of new bone in the defect area, and the effect was stronger after 8 weeks than at 6 weeks, improving the BV/TV and BMD in the defect area.
분자량

337.34

화학식

C18H18F3NO2
CAS No.
Appearance

Liquid (Density: 1.2230 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OCCCC)C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : ≥ 44 mg/mL (130.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9644 mL 14.8218 mL 29.6437 mL
5 mM 0.5929 mL 2.9644 mL 5.9287 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9644 mL 14.8218 mL 29.6437 mL 74.1092 mL
5 mM 0.5929 mL 2.9644 mL 5.9287 mL 14.8218 mL
10 mM 0.2964 mL 1.4822 mL 2.9644 mL 7.4109 mL
15 mM 0.1976 mL 0.9881 mL 1.9762 mL 4.9406 mL
20 mM 0.1482 mL 0.7411 mL 1.4822 mL 3.7055 mL
25 mM 0.1186 mL 0.5929 mL 1.1857 mL 2.9644 mL
30 mM 0.0988 mL 0.4941 mL 0.9881 mL 2.4703 mL
40 mM 0.0741 mL 0.3705 mL 0.7411 mL 1.8527 mL
50 mM 0.0593 mL 0.2964 mL 0.5929 mL 1.4822 mL
60 mM 0.0494 mL 0.2470 mL 0.4941 mL 1.2352 mL
80 mM 0.0371 mL 0.1853 mL 0.3705 mL 0.9264 mL
100 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.7411 mL
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Ufenamate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ufenamate67330-25-0Flufenamic acid butyl ester Butyl flufenamateCOXProstaglandin ReceptorCyclooxygenaseanthranilicanti-inflammatoryskindiseaseseczemacontactdermatitisdiapermiliariaatopicInhibitorinhibitorinhibit

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상품명:
Ufenamate
Cat. No.:
HY-100009
수량:
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