67330-25-0
Chemical Structure
Ufenamate
Synonym(s): Flufenamic acid butyl ester; Butyl flufenamate
- CAS No.: 67330-25-0
- Formula:C18H18F3NO2
- Molecular Weight:337.34
IUPAC Name: butyl 2-((3-(trifluoromethyl)phenyl)amino)benzoate
InChIKey: JDLSRXWHEBFHNC-UHFFFAOYSA-N
SMILES: O=C(OCCCC)C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2
Biological Activity: Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug that can be used in the study of skin diseases such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliary rashes and atopic dermatitis. Ufenamate has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging model, downregulates the expression level of COX-2 and can promote the healing of mouse skull defects by secreting BMP2[1][2][3][4].
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Ufenamate | 99.89% | Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug that can be used in the study of skin diseases such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliary rashes and atopic dermatitis. Ufenamate has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging model, downregulates the expression level of COX-2 and can promote the healing of mouse skull defects by secreting BMP2. | ||||||||||||||||||||
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Ufenamate (Standard) | ≥98% | Ufenamate (Standard) is the analytical standard of Ufenamate (HY-100009). This product is intended for research and analytical applications. Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug that can be used in the study of skin diseases such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliary rashes and atopic dermatitis. Ufenamate has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging model, downregulates the expression level of COX-2 and can promote the healing of mouse skull defects by secreting BMP2. | ||||||||||||||||||||
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References
- [1]. Iino H, et al. Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles. Biol Pharm Bull. 2015;38(10):1645-8. [Content Brief]
- [2]. Hayato Iino, et al. Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles. Bio Pharm Bull. 2015;38(10):1645-8. [Content Brief]
- [3]. Ting Lü, et al. Photoprotective effect of butyl flufenamate ointment on SKH-1 hairless mice. Chinese Journal of Dermatology ; (12): 711-715, 2013.
- [4]. Fan Yang, et al. Topical Application of Butyl Flufenamate Ointment Promotes Cranial Defect Healing in Mice by Inducing BMP2 Secretion in Skin Mesenchymal Stem Cells. Cells. 2022 Nov 15;11(22):3620. [Content Brief]
