2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Drug Metabolite mAChR
  4. Vinburnine

Vinburnine  (Synonyms: (-)-Eburnamonine; (-)-Vincamone)

製品番号: HY-B1180 純度: 98.30%
COA 取扱説明書 Technical Support

Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

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Vinburnine

Vinburnine 構造式

CAS 番号 : 4880-88-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 105 在庫あり
Solution
10 mM * 1 mL in DMSO USD 105 在庫あり
Solid
100 mg $96 在庫あり
200 mg $160 在庫あり
500 mg   お問い合わせ  
1 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Other Forms of Vinburnine:

Vinburnine 関連抗体

Top Publications Citing Use of Products

mAChR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

Cellular Effect
Cell Line Type Value Description References
KMS-12-BM IC50
>100 μM
Compound: 2
Cytotoxicity against human KMS-12-BM cells after 96 hrs by MTS assay
Cytotoxicity against human KMS-12-BM cells after 96 hrs by MTS assay
[PMID: 24055047]
LNCaP IC50
>100 μM
Compound: 2
Cytotoxicity against human LNCAP cells after 96 hrs by MTS assay
Cytotoxicity against human LNCAP cells after 96 hrs by MTS assay
[PMID: 24055047]
MDA-MB-231 IC50
41.8 μM
Compound: 2
Cytotoxicity against human MDA-MB-231 cells after 96 hrs by MTS assay
Cytotoxicity against human MDA-MB-231 cells after 96 hrs by MTS assay
[PMID: 24055047]
RPMI-8226 IC50
>100 μM
Compound: 2
Cytotoxicity against human RPMI8226 cells after 96 hrs by MTS assay
Cytotoxicity against human RPMI8226 cells after 96 hrs by MTS assay
[PMID: 24055047]
U-266 IC50
>100 μM
Compound: 2
Cytotoxicity against human U266 cells after 96 hrs by MTS assay
Cytotoxicity against human U266 cells after 96 hrs by MTS assay
[PMID: 24055047]
体外実験

Vinburnine is the allosteric modulator of muscarinic receptors M1-M4, decelerates the binding of [H]N-methylscopolamine to muscarinic M1-M4 receptors in CHO cell with EC50s of 29.5, 4.1, 9.5, and 15.0 μM, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vinburnine 関連抗体
体内実験

Vinburnine (5-50 mg/kg, ip, single dose) exhibits anti-amnesia effect in Scopolamine (HY-N0296)-induced mouse amnesia model[2].
Vinburnine promotes erythrocyte glycolysis, increases erythrocyte ATP and 2,3-diphosphoglycerol content, improves erythrocyte deformability and tissue oxygen delivery[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Scopolamine (HY-N0296)-induced mouse amnesia model[2]
Dosage: 5-50 mg/kg
Administration: ip, single dose
Result: Improved memory impairment.
分子量

294.40

分子式

C19H22N2O
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1C[C@@]2(CC)[C@@]3([H])C(N1C4=CC=CC=C54)=C5CCN3CCC2
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 8.33 mg/mL (28.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3968 mL 16.9838 mL 33.9676 mL
5 mM 0.6794 mL 3.3968 mL 6.7935 mL
10 mM 0.3397 mL 1.6984 mL 3.3968 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.83 mg/mL (2.82 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 0.83 mg/mL (2.82 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.78%

COA (257 KB) LCMS (137 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3968 mL 16.9838 mL 33.9676 mL 84.9191 mL
5 mM 0.6794 mL 3.3968 mL 6.7935 mL 16.9838 mL
10 mM 0.3397 mL 1.6984 mL 3.3968 mL 8.4919 mL
15 mM 0.2265 mL 1.1323 mL 2.2645 mL 5.6613 mL
20 mM 0.1698 mL 0.8492 mL 1.6984 mL 4.2460 mL
25 mM 0.1359 mL 0.6794 mL 1.3587 mL 3.3968 mL
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Vinburnine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vinburnine4880-88-0(-)-Eburnamonine(-)-VincamoneDrug MetabolitemAChRMuscarinic acetylcholine receptoramnesiaCHOanti-amnesiaInhibitorinhibitorinhibit

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製品番号:
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