2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. Adrenergic Receptor Caspase Bcl-2 Family
  4. Carteolol

Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research.

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Carteolol

Carteolol Estructura química

No. CAS : 51781-06-7

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Carteolol Related Antibodies

Top Publications Citing Use of Products

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α adrenergic receptor β adrenergic receptor

Ver todos los productos específicos de isoformas Caspase:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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Descripciòn

Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research[1].

In Vitro

Carteolol (0-2%; 0-28 hours; HCECs) has cytotoxicity and decreases cell viability in a dose- and time-dependent manner[1].
Carteolol (0.25%; 4-12 hours; HCECs) induces apoptosis and necroptotic protein expression in HCECs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carteolol Related Antibodies

Cell Viability Assay[1]

Cell Line: HCECs
Concentration: 0.00390625-2%
Incubation Time: 0, 2, 4, 8, 16, 20,24 and 28 hours
Result: Decreased cell viability with the concentrations above 0.0015625% in a dose- and time-dependent manner.

Western Blot Analysis[1]

Cell Line: HCECs
Concentration: 0.25%
Incubation Time: 4, 8 and 12 hours
Result: Dampened expression of the anti-apoptotic protein Bcl-2 and Bcl-xL, enhanced expression of the pro-apoptotic proteins Bax and Bad, and mitochondrial-released pro-apoptotic proteins Cyt.c and AIF.

Cell Cycle Analysis[1]

Cell Line: HCECs
Concentration: 0.25%
Incubation Time: 4, 8 and 12 hours
Result: Increased the number of G1 phase of the cell cycle, whereas decreased S phase.
Ensayo clínico
Peso molecular

292.37

Fòrmula

C16H24N2O3
No. CAS
SMILES

O=C1NC2=C(C(OCC(O)CNC(C)(C)C)=CC=C2)CC1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Carteolol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carteolol51781-06-7OPC-1085OPC1085OPC 1085Adrenergic ReceptorCaspaseBcl-2 FamilyBeta Receptorcytotoxicitynecroptosisapoptosiscorneal endothelial cellsInhibitorinhibitorinhibit

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Nombre del producto:
Carteolol
Cat. No.:
HY-17495
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