2. MAPK/ERK Pathway Membrane Transporter/Ion Channel Immunology/Inflammation Metabolic Enzyme/Protease NF-κB
  3. p38 MAPK VDAC Interleukin Related Reactive Oxygen Species (ROS)
  4. Cyanidin-3-O-arabinoside

Cyanidin-3-O-arabinoside is a p38 MAPK phosphorylation inhibitor. Cyanidin-3-O-arabinoside reduces the expression of VDAC1, inhibits mtROS accumulation, reverses cellular senescence, blocks excessive mitochondrial calcium influx, reduces the formation of mitochondria-associated endoplasmic reticulum membranes, and suppresses the VDAC1-IP3R1 interaction. Cyanidin-3-O-arabinoside activates hair follicle stem cell proliferation and improves the condition of slowed hair growth. Cyanidin-3-O-arabinoside is applicable to research related to colon cancer and androgenetic alopecia.

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Cyanidin-3-O-arabinoside

Cyanidin-3-O-arabinoside Chemische Struktur

CAS. Nr. : 111613-04-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Cyanidin-3-O-arabinoside:

Cyanidin-3-O-arabinoside Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Cyanidin-3-O-arabinoside

Alle p38 MAPK Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

Alle VDAC Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
VDAC1 VDAC2 VDAC3

Alle Interleukin Related Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Beschreibung

Cyanidin-3-O-arabinoside is a p38 MAPK phosphorylation inhibitor. Cyanidin-3-O-arabinoside reduces the expression of VDAC1, inhibits mtROS accumulation, reverses cellular senescence, blocks excessive mitochondrial calcium influx, reduces the formation of mitochondria-associated endoplasmic reticulum membranes, and suppresses the VDAC1-IP3R1 interaction. Cyanidin-3-O-arabinoside activates hair follicle stem cell proliferation and improves the condition of slowed hair growth. Cyanidin-3-O-arabinoside is applicable to research related to colon cancer and androgenetic alopecia[1][2].

IC50 & Target[1][2]

VDAC1

 

IL-6

 

In Vitro

Cyanidin-3-O-arabinoside exhibits strong binding affinity with purified human APN, JAK3 and EZH2 proteins[1].
Cyanidin-3-O-arabinoside (120-320 μg/mL; 24-72 h) potently inhibits the proliferation of Caco-2 cells in a concentration- and time-dependent manner[1].
Cyanidin-3-O-arabinoside (120-280 μg/mL; 72 h) induces concentration-dependent apoptosis and cell cycle arrest in Caco-2 cells, and increases the accumulation of cells in the G0/G1 phase[1].
Cyanidin-3-O-arabinoside (120-280 μg/mL; 72 h) exerts a concentration-dependent regulatory effect on apoptosis-related proteins in Caco-2 cells, upregulating the expression of Bax and downregulating the expression of Bcl-2 after 72 h of treatment[1].
Cyanidin-3-O-arabinoside (1 μM; 30 min pre-incubation, 72 h co-incubation with DHT) reverses dihydrotestosterone (DHT)-induced senescence in human dermal papilla cells (DPCs) by reducing the number of SA-β-gal-positive cells and inhibiting the expression of senescence markers (p21, p16)[2].
Cyanidin-3-O-arabinoside (1 μM; 30 min pre-incubation, 48 h co-incubation with DHT) effectively reduces dihydrotestosterone (DHT)-induced mtROS accumulation in human dermal papilla cells (DPCs)[2].
Cyanidin-3-O-arabinoside (1 μM; 30 min pre-incubation, 2 h co-incubation with DHT) inhibits dihydrotestosterone (DHT)-induced reactive oxygen species (ROS) production in human dermal papilla cells (DPCs)[2].
Cyanidin-3-O-arabinoside (1 μM; 30 min pre-incubation, 48 h co-incubation with DHT) blocks dihydrotestosterone (DHT)-induced excessive mitochondrial calcium accumulation in human dermal papilla cells (DPCs)[2].
Cyanidin-3-O-arabinoside (1 μM; 30 min pre-incubation, 24 h co-incubation with DHT) reduces dihydrotestosterone (DHT)-induced formation of mitochondria-associated endoplasmic reticulum membranes (MAM) in human dermal papilla cells (DPCs) by inhibiting VDAC1 expression and the VDAC1-IP3R1 interaction[2].
Cyanidin-3-O-arabinoside (1 μM; 30 min pre-incubation, co-incubation with DHT) inhibits dihydrotestosterone (DHT)-induced AR transcriptional activity in human dermal papilla cells (DPCs)[2].
Cyanidin-3-O-arabinoside (1 μM; 30 min pre-incubation, 72 h co-incubation with DHT for DPCs). Pretreatment of human dermal papilla cells (DPCs) exposed to dihydrotestosterone (DHT) with this medium restores the proliferation of human hair follicle stem cells (HFSCs) and reduces the expression of HFSC senescence markers[2].
Cyanidin-3-O-arabinoside (1 μM; 30 min pre-incubation, 24 h co-incubation with DHT for qPCR, 72 h co-incubation with DHT for ELISA) reverses the dihydrotestosterone (DHT)-induced upregulation of hair follicle regulators (DKK1, TGFB1, IL6) at both mRNA and protein levels in human dermal papilla cells (DPCs)[2].
Cyanidin-3-O-arabinoside (1 μM; 30 min pre-incubation, 2 h co-incubation with DHT) inhibits dihydrotestosterone (DHT)-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK) and subsequent phosphorylation of HSP27 in human dermal papilla cells (DPCs)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyanidin-3-O-arabinoside Related Antibodies

Cell Proliferation Assay[1]

Cell Line: human colon adenocarcinoma Caco-2 cells
Concentration: 120, 160, 200, 240, 280, 320 μg/mL
Incubation Time: 24, 48, 72 h
Result: Inhibited Caco-2 cell proliferation in a concentration- and time-dependent manner.
Achieved an inhibition rate of 93.5% at 72 h with 320 μg/mL.
Exhibited IC50 values of 227, 124, and 112 μg/mL for 24, 48, and 72 h treatments, respectively.

Apoptosis Analysis[1]

Cell Line: human colon adenocarcinoma Caco-2 cells
Concentration: 120, 160, 200, 240, 280 μg/mL
Incubation Time: 72 h
Result: Induced Caco-2 cell apoptosis in a concentration-dependent manner.
Increased the proportion of late apoptotic cells from 1.3% (untreated) to 40.7% at 280 μg/mL.
Reached a total apoptosis rate of 50% at 280 μg/mL.

Cell Cycle Analysis[1]

Cell Line: human colon adenocarcinoma Caco-2 cells
Concentration: 120, 160, 200, 240, 280 μg/mL
Incubation Time: 72 h
Result: Altered Caco-2 cell cycle distribution in a concentration-dependent manner.
Increased the proportion of cells in G0/G1 phase from 45.1% (untreated) to 73.5% at 280 μg/mL.
Decreased the proportion of cells in S phase from 37.3% (untreated) to 17.3% at 280 μg/mL.

Western Blot Analysis[1]

Cell Line: human colon adenocarcinoma Caco-2 cells
Concentration: 120, 160, 200, 240, 280 μg/mL
Incubation Time: 72 h
Result: Regulated Bcl-2 and Bax protein expression in a concentration-dependent manner.
Increased Bax expression with higher cyanidin-3-O-arabinoside concentrations.
Decreased Bcl-2 expression with higher cyanidin-3-O-arabinoside concentrations.

Cell Proliferation Assay[2]

Cell Line: human dermal papilla cells (DPCs), human hair follicle stem cells (HFSCs)
Concentration: 1 μM
Incubation Time: 30 min (pre-incubation); 72 h (co-incubation with DHT for DPCs); 48 h (HFSC culture with conditioned media)
Result: Reduced the deleterious effect of DHT-treated DPC-conditioned media on HFSC proliferation.
Reversed DHT-induced downregulation of FGF4 and FGF6 in DPC-conditioned media.
Decreased senescence marker (p16, p21) expression in HFSCs exposed to DHT-treated conditioned media.

Western Blot Analysis[2]

Cell Line: human dermal papilla cells (DPCs)
Concentration: 1 μM
Incubation Time: 30 min (pre-incubation); 2 h (co-incubation with DHT)
Result: Reduced DHT-induced phosphorylation of p38, while not significantly affecting phosphorylation of ERK or JNK.
Reversed DHT-induced phosphorylation of HSP27.

Real Time qPCR[2]

Cell Line: human dermal papilla cells (DPCs)
Concentration: 1 μM
Incubation Time: 24 h co-incubation with DHT
Result: Reversed dihydrotestosterone (DHT)-induced upregulation of hair follicle-regulatory factors (DKK1, TGFB1, IL6) in human dermal papilla cells (DPCs) at both mRNA and protein levels.
In Vivo

Cyanidin-3-O-arabinoside (500 μM; topical; once every 2 days; 19 days) restores DHT-induced hair growth deceleration in an androgenetic alopecia mouse model by reversing reductions in hair bulb diameter, skin thickness, dermal ratio, and hair follicle stem cell proliferation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (7-week-old male, androgenetic alopecia model via DHT injection + shaving/depilation)[2]
Dosage: 500 μM
Administration: topical; once every 2 days; 19 days
Result: Restored DHT-induced hair growth deceleration.
Reversed DHT-induced reduction in hair bulb diameter, skin thickness, and dermal ratio to levels comparable to non-DHT treated control mice.
Increased normalized fluorescence intensity of Ki67 in hair follicle regions, reversing DHT-induced reduction in Ki67 signal.
Molekulargewicht

454.81

Formel

C20H19ClO10
CAS. Nr.
Appearance

Solid

Color

Brown to black

SMILES

OC1=CC2=[O+]C(C3=CC=C(O)C(O)=C3)=C(O[C@H]4[C@@H]([C@H]([C@H](CO4)O)O)O)C=C2C(O)=C1.[Cl-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit
In Vitro: 

Ethanol : 4.5 mg/mL (9.89 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1987 mL 10.9936 mL 21.9872 mL
5 mM 0.4397 mL 2.1987 mL 4.3974 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.1987 mL 10.9936 mL 21.9872 mL 54.9680 mL
5 mM 0.4397 mL 2.1987 mL 4.3974 mL 10.9936 mL
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Cyanidin-3-O-arabinoside Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyanidin-3-O-arabinoside111613-04-8p38 MAPKVDACInterleukin RelatedReactive Oxygen Species (ROS)Voltage-dependent anion channel ILhair follicle stem cellandrogenetic alopeciaJAK3mtROSVDAC1EZH2p38 mitogen-activated protein kinasecell senescencecolon cancerhuman APNInhibitorinhibitorinhibit

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