2. PI3K/Akt/mTOR
  3. PI3K
  4. Gallein

ガレイン  (Synonyms: Gallein; Pyrogallol phthalein)

製品番号: HY-D0254 純度: 98.0%
COA 取扱説明書 Technical Support

Gallein is a Gβγ subunit signaling inhibitor that can interfere with the interaction between Gβγ subunit and PI3Kγ, regulate platelet function, and exhibit anti-tumor activity[1][3].

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CAS 番号 : 2103-64-2

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 44 在庫あり
Solution
10 mM * 1 mL in DMSO USD 44 在庫あり
Solid
5 mg $40 在庫あり
10 mg $55 在庫あり
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カスタマーレビュー

Based on 9 publication(s) in Google Scholar

Other Forms of Gallein:

ガレイン 関連抗体

Top Publications Citing Use of Products

    Gallein purchased from MedChemExpress. Usage Cited in: Water Biol Secur. 2025 Sep 18.

    The percentage of mandarin fish ingesting live fish fry after 2-h immersion in the Gβγ signaling inhibitor Gallein (0.01, 0.1, and 1 μmol/L) across treatment groups.

    Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723.  [Abstract]

    Statistic result showing that in the SVF-derived adipocytes, treatment with inhibitor for Gαi (PTX) or Gβγ (Gallein, 10 μM, pretreated with 4 h) abolished the lactate-induced activation of ATF2.

    Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723.  [Abstract]

    Representative western blots and statistical results showing that the lactate-induced activation of p38-ATF2 and upregulation of UCP1 were blocked by inhibitor for Gαi (PTX) or Gβγ (Gallein, 10 μM, pretreated with 4 h).

    Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723.  [Abstract]

    Injection of inhibitor for p38 (SB203580), ROCK1 (Y-27632) or Gβγ (Gallein, 10 μM, pretreated with 4 h) into the inguinal fat pads in the tumour-bearing mice alleviated tumour-induced losses of body weight .

    Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723.  [Abstract]

    Injection of inhibitor for p38 (SB203580), ROCK1 (Y-27632) or Gβγ (Gallein, 10 μM, pretreated with 4 h) into the inguinal fat pads in the tumour-bearing mice alleviated tumour-induced losses of tissue weights.

    PI3K アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Gallein is a Gβγ subunit signaling inhibitor that can interfere with the interaction between Gβγ subunit and PI3Kγ, regulate platelet function, and exhibit anti-tumor activity[1][3].
    IC50 & Target

    Gβγ subunit
    体外実験

    Gallein (10  μM, 0-150 h) inhibits β-ionone induced cell invasion in LNCaP prostate cancer cells[1].
    Gallein (30 μM, 1 h) increases osteoprotegerin (OPG) synthesis induced by fibroblast growth factor 2 (FGF-2) in osteoblasts[2].
    Gallein (25-50 μM, 24 h) inhibits platelet aggregation, secretion, and diffusion functions[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ガレイン 関連抗体

    Cell Invasion Assay[1].

    Cell Line: LNCaP cell
    Concentration: 10  μM
    Incubation Time: 0-150 h
    Result: Inhibited LNCaP cell invasion

    Real Time qPCR[2].

    Cell Line: Osteoblast-like MC3T3-E1 cell
    Concentration: 30  μM
    Incubation Time: 1 h
    Result: Enhanced the FGF-2-induced OPG/Tnfrsf11b mRNA expression

    Western Blot Analysis[3].

    Cell Line: Platelet
    Concentration: 25-50  μM
    Incubation Time: 24 h
    Result: Reduced phosphorylation of Akt
    体内実験

    Gallein (5 mg/kg, 15 days, i.p.) inhibits tumor cell proliferation in male NSG mice[1].
    Gallein (20 mg/kg, b.i.d, i.v.) regulates hemostasis and prevents arterial thrombosis in C57BL/6 mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Castrated male NSG mice[1].
    Dosage: 5 mg/kg
    Administration: Intraperitoneal injection (i.p.); 15 days
    Result: Reduced the number of metastasised tissues
    Animal Model: C57BL/6 mice[3].
    Dosage: 20 mg/kg
    Administration: Intravenous injection (i.v.); twice per day; 3 days
    Result: Extended tail bleeding time
    分子量

    364.31

    分子式

    C20H12O7
    CAS 番号
    Appearance

    Solid

    Color

    Dark purple to black

    SMILES

    O=C1OC2(C3=C(OC4=C2C=CC(O)=C4O)C(O)=C(O)C=C3)C5=C1C=CC=C5
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    DMSO : 33.33 mg/mL (91.49 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7449 mL 13.7246 mL 27.4492 mL
    5 mM 0.5490 mL 2.7449 mL 5.4898 mL
    10 mM 0.2745 mL 1.3725 mL 2.7449 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    一般には略語で表示されます：C1V1 = C2V2

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    純度とドキュメンテーション

    純度: 98.0%

    COA (257 KB) HNMR (266 KB) MS (68 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7449 mL 13.7246 mL 27.4492 mL 68.6229 mL
    5 mM 0.5490 mL 2.7449 mL 5.4898 mL 13.7246 mL
    10 mM 0.2745 mL 1.3725 mL 2.7449 mL 6.8623 mL
    15 mM 0.1830 mL 0.9150 mL 1.8299 mL 4.5749 mL
    20 mM 0.1372 mL 0.6862 mL 1.3725 mL 3.4311 mL
    25 mM 0.1098 mL 0.5490 mL 1.0980 mL 2.7449 mL
    30 mM 0.0915 mL 0.4575 mL 0.9150 mL 2.2874 mL
    40 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7156 mL
    50 mM 0.0549 mL 0.2745 mL 0.5490 mL 1.3725 mL
    60 mM 0.0457 mL 0.2287 mL 0.4575 mL 1.1437 mL
    80 mM 0.0343 mL 0.1716 mL 0.3431 mL 0.8578 mL
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    Gallein Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Gallein2103-64-2Pyrogallol phthaleinPI3KPhosphoinositide 3-kinaseplatelet functionthrombosisMC3T3-E1 cellInhibitorinhibitorinhibit

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    製品番号:
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