2. PI3K/Akt/mTOR
  3. PI3K
  4. Gallein

Gallein  (Synonyms: Pyrogallol phthalein)

Cat. No.: HY-D0254 Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

Gallein is a Gβγ subunit signaling inhibitor that can interfere with the interaction between Gβγ subunit and PI3Kγ, regulate platelet function, and exhibit anti-tumor activity[1][3].

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CAS No. : 2103-64-2

사이즈 가격 재고 수량
무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 9 publication(s) in Google Scholar

Other Forms of Gallein:

Gallein Related Antibodies

Top Publications Citing Use of Products

    Gallein purchased from MedChemExpress. Usage Cited in: Water Biol Secur. 2025 Sep 18.

    The percentage of mandarin fish ingesting live fish fry after 2-h immersion in the Gβγ signaling inhibitor Gallein (0.01, 0.1, and 1 μmol/L) across treatment groups.

    Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723.  [Abstract]

    Statistic result showing that in the SVF-derived adipocytes, treatment with inhibitor for Gαi (PTX) or Gβγ (Gallein, 10 μM, pretreated with 4 h) abolished the lactate-induced activation of ATF2.

    Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723.  [Abstract]

    Representative western blots and statistical results showing that the lactate-induced activation of p38-ATF2 and upregulation of UCP1 were blocked by inhibitor for Gαi (PTX) or Gβγ (Gallein, 10 μM, pretreated with 4 h).

    Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723.  [Abstract]

    Injection of inhibitor for p38 (SB203580), ROCK1 (Y-27632) or Gβγ (Gallein, 10 μM, pretreated with 4 h) into the inguinal fat pads in the tumour-bearing mice alleviated tumour-induced losses of body weight .

    Gallein purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Apr;6(4):708-723.  [Abstract]

    Injection of inhibitor for p38 (SB203580), ROCK1 (Y-27632) or Gβγ (Gallein, 10 μM, pretreated with 4 h) into the inguinal fat pads in the tumour-bearing mice alleviated tumour-induced losses of tissue weights.

    View All PI3K Isoform Specific Products:

    View All Isoforms
    PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

    • Biological Activity

    • 순도&문서

    • References

    • 고객리뷰

    제품 설명

    Gallein is a Gβγ subunit signaling inhibitor that can interfere with the interaction between Gβγ subunit and PI3Kγ, regulate platelet function, and exhibit anti-tumor activity[1][3].
    IC50 & Target

    Gβγ subunit
    In Vitro

    Gallein (10  μM, 0-150 h) inhibits β-ionone induced cell invasion in LNCaP prostate cancer cells[1].
    Gallein (30 μM, 1 h) increases osteoprotegerin (OPG) synthesis induced by fibroblast growth factor 2 (FGF-2) in osteoblasts[2].
    Gallein (25-50 μM, 24 h) inhibits platelet aggregation, secretion, and diffusion functions[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Gallein Related Antibodies

    Cell Invasion Assay[1].

    Cell Line: LNCaP cell
    Concentration: 10  μM
    Incubation Time: 0-150 h
    Result: Inhibited LNCaP cell invasion

    Real Time qPCR[2].

    Cell Line: Osteoblast-like MC3T3-E1 cell
    Concentration: 30  μM
    Incubation Time: 1 h
    Result: Enhanced the FGF-2-induced OPG/Tnfrsf11b mRNA expression

    Western Blot Analysis[3].

    Cell Line: Platelet
    Concentration: 25-50  μM
    Incubation Time: 24 h
    Result: Reduced phosphorylation of Akt
    In Vivo

    Gallein (5 mg/kg, 15 days, i.p.) inhibits tumor cell proliferation in male NSG mice[1].
    Gallein (20 mg/kg, b.i.d, i.v.) regulates hemostasis and prevents arterial thrombosis in C57BL/6 mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Castrated male NSG mice[1].
    Dosage: 5 mg/kg
    Administration: Intraperitoneal injection (i.p.); 15 days
    Result: Reduced the number of metastasised tissues
    Animal Model: C57BL/6 mice[3].
    Dosage: 20 mg/kg
    Administration: Intravenous injection (i.v.); twice per day; 3 days
    Result: Extended tail bleeding time
    분자량

    364.31

    화학식

    C20H12O7
    CAS No.
    Appearance

    Solid

    Color

    Dark purple to black

    SMILES

    O=C1OC2(C3=C(OC4=C2C=CC(O)=C4O)C(O)=C(O)C=C3)C5=C1C=CC=C5
    선적

    Room temperature in continental US; may vary elsewhere.
    보관

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    용액&용해도
    In Vitro: 

    DMSO : 33.33 mg/mL (91.49 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7449 mL 13.7246 mL 27.4492 mL
    5 mM 0.5490 mL 2.7449 mL 5.4898 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • 몰농도 계산기

    • 농도 희석 계산기

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    순도&문서

    Purity: 98.0%

    SDS (393 KB)

    COA (257 KB) HNMR (266 KB) MS (68 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7449 mL 13.7246 mL 27.4492 mL 68.6229 mL
    5 mM 0.5490 mL 2.7449 mL 5.4898 mL 13.7246 mL
    10 mM 0.2745 mL 1.3725 mL 2.7449 mL 6.8623 mL
    15 mM 0.1830 mL 0.9150 mL 1.8299 mL 4.5749 mL
    20 mM 0.1372 mL 0.6862 mL 1.3725 mL 3.4311 mL
    25 mM 0.1098 mL 0.5490 mL 1.0980 mL 2.7449 mL
    30 mM 0.0915 mL 0.4575 mL 0.9150 mL 2.2874 mL
    40 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7156 mL
    50 mM 0.0549 mL 0.2745 mL 0.5490 mL 1.3725 mL
    60 mM 0.0457 mL 0.2287 mL 0.4575 mL 1.1437 mL
    80 mM 0.0343 mL 0.1716 mL 0.3431 mL 0.8578 mL
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    Gallein Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Gallein2103-64-2Pyrogallol phthaleinPI3KPhosphoinositide 3-kinaseplatelet functionthrombosisMC3T3-E1 cellInhibitorinhibitorinhibit

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    상품명:
    Gallein
    Cat. No.:
    HY-D0254
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    SAFETY DATA SHEET (SDS)

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