2. GPCR/G Protein Neuronal Signaling Anti-infection
  3. Adrenergic Receptor Parasite
  4. Guanabenz

Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Guanabenz

Guanabenz 構造式

CAS 番号 : 5051-62-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 49 在庫あり
Solution
10 mM * 1 mL in DMSO USD 49 在庫あり
Solid
5 mg $45 在庫あり
10 mg $65 在庫あり
25 mg $115 在庫あり
50 mg $160 在庫あり
100 mg $230 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Guanabenz:

Guanabenz 関連抗体

Top Publications Citing Use of Products

Adrenergic Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
α adrenergic receptor β adrenergic receptor

Parasite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure[1][2][3].

IC50 & Target

Toxoplasma

 

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
4.85 μM
Compound: Guanabenz
Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay
Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay
[PMID: 28230985]
HEK-293T EC50
0.09 μM
Compound: 16a
Agonist activity at human TAAR1 receptor expressed in HEK293T cells cotransfected with beta-2 receptor assessed as cAMP production by BRET assay
Agonist activity at human TAAR1 receptor expressed in HEK293T cells cotransfected with beta-2 receptor assessed as cAMP production by BRET assay
10.1039/C5MD00400D
体外実験

Guanabenz (0.5-50 μM, 24 h) is treated with increasing concentrations for 24 hours not affect cell viability[1].
Guanabenz (0.5-50 μM, 24 h) alone not affects the UPR targets, neither on mRNA or protein level nor the phosphorylation status of eIF2a. Guanabenz also not induces GADD34 or the constitutively active form CReP[1].
Guanabenz (0.5-50 μM, 24 h) alone not induces ER stress in neonatal rat cardiomyocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Guanabenz 関連抗体

Cell Viability Assay[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Did not affect cell survival.

RT-PCR[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Did not affect levels of UPR targets.

Western Blot Analysis[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Increased the levels of low panel concentration-dependent UPR targets proteins.
体内実験

Guanabenz (5 mg/kg/day; i.p.; for 3 weeks) can reproducibly reduce brain cyst burden[2].
Guanabenz (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice[2].
Guanabenz (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/cJ mice[2]
Dosage: 5 mg/kg
Administration: 5 mg/kg/day; i.p. ; for 3 weeks
Result: Reduced the latent brain cysts in both male and female BALB/cJ mice.
Animal Model: BALB/cJ mice[2]
Dosage: 5 mg/kg; 10 mg/kg
Administration: 5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks
Result: Reversed parasite-induced hyperactivity to near-baseline levels.
Animal Model: Cats[3]
Dosage: 100 and 320 μg/kg and 1 mg/kg
Administration: 100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min
Result: Declined markedly blood pressure and nerve activity.
臨床実験
分子量

231.08

分子式

C8H8Cl2N4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 16.67 mg/mL (72.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3275 mL 21.6375 mL 43.2751 mL
5 mM 0.8655 mL 4.3275 mL 8.6550 mL
10 mM 0.4328 mL 2.1638 mL 4.3275 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.85%

COA (247 KB) HNMR (253 KB) LCMS (94 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3275 mL 21.6375 mL 43.2751 mL 108.1876 mL
5 mM 0.8655 mL 4.3275 mL 8.6550 mL 21.6375 mL
10 mM 0.4328 mL 2.1638 mL 4.3275 mL 10.8188 mL
15 mM 0.2885 mL 1.4425 mL 2.8850 mL 7.2125 mL
20 mM 0.2164 mL 1.0819 mL 2.1638 mL 5.4094 mL
25 mM 0.1731 mL 0.8655 mL 1.7310 mL 4.3275 mL
30 mM 0.1443 mL 0.7213 mL 1.4425 mL 3.6063 mL
40 mM 0.1082 mL 0.5409 mL 1.0819 mL 2.7047 mL
50 mM 0.0866 mL 0.4328 mL 0.8655 mL 2.1638 mL
60 mM 0.0721 mL 0.3606 mL 0.7213 mL 1.8031 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Guanabenz Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanabenz5051-62-7Adrenergic ReceptorParasiteBeta Receptorα-2-adrenoceptorantihypertensiveantiparasiticERhigh blood pressureInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Guanabenz
製品番号:
HY-12724
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.