Kanamycin (Synonyms: Kanamycin A)

Name: Kanamycin
Brand: MedChemExpress
SKU: HY-16566
Rating: 5.0 (29 reviews)

Art. -Nr.: HY-16566 Reinheit: 99.97%: Data Sheet
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Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia.

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CAS. Nr. : 59-01-8

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	Auf Lager	Estimated Time of Arrival: December 31
Solid
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Auf Lager	Estimated Time of Arrival: December 31
500 mg	Angebot einholen
1 g	Angebot einholen

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Based on 29 publication(s) in Google Scholar

Other Forms of Kanamycin:

29 Publications Citing Use of MCE Kanamycin

Microbiological Assay

: Kanamycin purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]; Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Antibiotic Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

Biologische Aktivität
Reinheit & Dokumentation
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Beschreibung

IC₅₀ & Target

Aminoglycoside

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	IC₅₀	>100 6 Compound: KAN	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay	[PMID: 24087924]
Vero	IC₅₀	> 100 6 Compound: KAN	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay	[PMID: 24087924]
Vero	IC₅₀	> 100 6 Compound: KAN	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay	[PMID: 24087924]

In Vitro

Kanamycin (0.1-100 μg/mL; 2 weeks) exhibits good antibacterial activity (MIC=1-5 μg/mL) to various strains of mycobacteria in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	mycobacteria H37Rv, H2, H37RvR-PAS, Ravenel, Kirchbergand and BCG.
Concentration:	0.1-100 μg/mL
Incubation Time:	2 weeks
Result:	Showed good antibacterial activity to various strains of mycobacteria (H37Rv, H2, H37RvR-PAS, Ravenel, and BCG) with MICs were 1 μg/mL and 5 μg/mL for strain of Kirchbergand.

In Vivo

Kanamycin (2, 4 mg/kg; s.c.; once daily, 6 times a week for 3 weeks) inhibits growth of bovine tubercle bacilli in lung and spleen of mice^[1].
Kanamycin (1.25, 5 mg/kg; s.c.; single (at 3 h after infection)) inhibits the multiplication of K. pneumonia DT-S in lung, trachea, and blood of mice and in proportion to the dose administration, and also increases the survival rate of mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Inbred strain normal mice (14-16 g; bovine tubercle bacilli (Ravenel strain) infected model)^[1].
Dosage:	2, 4 mg/kg
Administration:	Subcutaneous injection; once daily, 6 times a week for 3 weeks.
Result:	Exerted a marked effect to inhibit the multiplication of the tuberculosis in vivo, especially in the lung of mice.

Animal Model:	Slc:ICR male mice (4-week-old; 18-24 g; K. pneumonia DT-S infection model (by the aerosol method))^[2].
Dosage:	1.25, 5 mg/kg
Administration:	Subcutaneous administration; single (at 3 h after infection).
Result:	Suppressed the growth of K. pneumonia DT-S in lung, trachea, and blood in proportion to the dose administration. Resulted in 90% survival at 6 days after infection (negative control group: all died within 4 days), and cleared the K. pneumonia DT-S from lung, trachea, and blood of mice within 48 h (when dosage at 5 mg/kg).

Klinische Studie

Molekulargewicht

484.50

Formel

C₁₈H₃₆N₄O₁₁

CAS. Nr.

59-01-8

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)([H])O[C@H](CN)[C@@H](O)[C@@H]1O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 70 mg/mL (144.48 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0640 mL	10.3199 mL	20.6398 mL
5 mM	0.4128 mL	2.0640 mL	4.1280 mL
10 mM	0.2064 mL	1.0320 mL	2.0640 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.97%

Select Batch:

Data Sheet (282 KB) SDS (396 KB)

COA (253 KB) HNMR (269 KB) RP-HPLC (215 KB)

Handling Instructions (2659 KB)

Verweise

[1]. YANAGISAWA K, et al. Studies on kanamycin, a new antibiotic against tubercle bacilli. I. Effect on virulent tubercle bacilli in vitro and in mice. J Antibiot (Tokyo). 1957 Nov;10(6):233-5. [Content Brief]

[2]. Nishi T, et al. Experimental respiratory tract infection with Klebsiella pneumoniae DT-S in mice: chemotherapy with kanamycin. Antimicrob Agents Chemother. 1980 Mar;17(3):494-505. [Content Brief]

[3]. Misumi M, et al. Interaction of kanamycin and related antibiotics with the large subunit of ribosomes and the inhibition of translocation. Biochem Biophys Res Commun. 1978 Sep 29;84(2):358-65. [Content Brief]

[4]. Misumi M, et al. Mechanism of inhibition of translocation by kanamycin and viomycin: a comparative study with fusidic acid. Biochem Biophys Res Commun. 1980 Jan 29;92(2):647-54. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.0640 mL	10.3199 mL	20.6398 mL	51.5996 mL
	5 mM	0.4128 mL	2.0640 mL	4.1280 mL	10.3199 mL
	10 mM	0.2064 mL	1.0320 mL	2.0640 mL	5.1600 mL
	15 mM	0.1376 mL	0.6880 mL	1.3760 mL	3.4400 mL
	20 mM	0.1032 mL	0.5160 mL	1.0320 mL	2.5800 mL
	25 mM	0.0826 mL	0.4128 mL	0.8256 mL	2.0640 mL
	30 mM	0.0688 mL	0.3440 mL	0.6880 mL	1.7200 mL
	40 mM	0.0516 mL	0.2580 mL	0.5160 mL	1.2900 mL
	50 mM	0.0413 mL	0.2064 mL	0.4128 mL	1.0320 mL
	60 mM	0.0344 mL	0.1720 mL	0.3440 mL	0.8600 mL
	80 mM	0.0258 mL	0.1290 mL	0.2580 mL	0.6450 mL
	100 mM	0.0206 mL	0.1032 mL	0.2064 mL	0.5160 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Kanamycin Related Classifications

Inflammation/Immunology Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kanamycin59-01-8Kanamycin AAntibioticBacterialtuberculosismycobacteriabovine tubercle bacillistreptomycinK. pneumoniapneumoniaInhibitorinhibitorinhibit

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Kanamycin (Synonyms: Kanamycin A)

Kundenbewertung

Other Forms of Kanamycin:

Kanamycin Related Antibodies

29 Publications Citing Use of MCE Kanamycin

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Antibiotic Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Kanamycin Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

Kanamycin Related Classifications

Keywords:

Ihre kürzlich angesehenen Produkte:

Kundenbewertung

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SAFETY DATA SHEET (SDS)

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