2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Bacterial Antibiotic
  4. Lincomycin hydrochloride

Lincomycin hydrochloride  (Synonyms: U10149A)

製品番号: HY-B0417A 純度: 99.59%
COA 取扱説明書 Technical Support

Lincomycin hydrochloride (U10149A) is an orally active lincosamide antibiotic. Lincomycin hydrochloride binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice.

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Lincomycin hydrochloride

Lincomycin hydrochloride 構造式

CAS 番号 : 859-18-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in Water USD 33 在庫あり
Solid
100 mg $30 在庫あり
500 mg $50 在庫あり
1 g $75 在庫あり
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* アイテムを追加する前、数量をご選択ください

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Based on 5 publication(s) in Google Scholar

Other Forms of Lincomycin hydrochloride:

Lincomycin hydrochloride 関連抗体

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製品説明

Lincomycin hydrochloride (U10149A) is an orally active lincosamide antibiotic. Lincomycin hydrochloride binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice[1][2][3].

体外実験

Lincomycin (0.5-10 μg/mL; 10 days) hydrochloride can enhance the biosynthesis of actinorhodin and undecylprodigiosin in liquid-cultured Streptomyces coelicolor A3(2) 1147[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lincomycin hydrochloride 関連抗体
体内実験

Lincomycin (33 mg/kg; p.o.; ad libitum daily; 8 weeks) hydrochloride increases body weight by 50.11%, induces early-stage NAFLD and type 2 diabetes-related metabolic dysfunction, disrupts gut microbiota structure and promotes antimicrobial resistance development, and suppresses intestinal inflammatory responses in male ICR mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR (6-week-old male)[3]
Dosage: 33 mg/kg
Administration: p.o.; ad libitum daily; 8 weeks
Result: Resulted in a significant
increase in growth rate of mice (50.11 %) over an 8 weeks period.
Caused suppression in inflammatory response.
Exhibited altered lipid profiles and liver damage suggestive of early-stage non-alcoholic fatty liver disease (NAFLD).
分子量

443.00

分子式

C18H35ClN2O6S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H](O)[C@@]([C@@]([C@@H]([C@H](O)[C@H]1O)O)([H])O[C@@H]1SC)([H])NC([C@@H]2C[C@@H](CCC)CN2C)=O.Cl
Structure Classification
Initial Source

Streptomyces lincolnensis
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (225.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2573 mL 11.2867 mL 22.5734 mL
5 mM 0.4515 mL 2.2573 mL 4.5147 mL
10 mM 0.2257 mL 1.1287 mL 2.2573 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.59%

COA (251 KB) HNMR (272 KB) RP-HPLC (278 KB) MS (69 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.2573 mL 11.2867 mL 22.5734 mL 56.4334 mL
5 mM 0.4515 mL 2.2573 mL 4.5147 mL 11.2867 mL
10 mM 0.2257 mL 1.1287 mL 2.2573 mL 5.6433 mL
15 mM 0.1505 mL 0.7524 mL 1.5049 mL 3.7622 mL
20 mM 0.1129 mL 0.5643 mL 1.1287 mL 2.8217 mL
25 mM 0.0903 mL 0.4515 mL 0.9029 mL 2.2573 mL
30 mM 0.0752 mL 0.3762 mL 0.7524 mL 1.8811 mL
40 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.4108 mL
50 mM 0.0451 mL 0.2257 mL 0.4515 mL 1.1287 mL
60 mM 0.0376 mL 0.1881 mL 0.3762 mL 0.9406 mL
80 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7054 mL
100 mM 0.0226 mL 0.1129 mL 0.2257 mL 0.5643 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lincomycin hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lincomycin859-18-7U10149ADNA/RNA SynthesisBacterialAntibioticInhibitorinhibitorinhibit

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