Methyl palmitate

Name: Methyl palmitate
Brand: MedChemExpress
SKU: HY-N1482
Rating: 4.5 (0 reviews)

Cat. No.: HY-N1482 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Methyl palmitate is a naturally occurring fatty acid ester. Methyl palmitate is a potent inhibitor of ΙκB phosphorylation. Methyl palmitate modulates macrophage activity and down-regulates pro-inflammatory mediators such as TNF-α and nitric oxide (NO). Methyl palmitate possesses anti-inflammatory and antifibrotic effects. Methyl palmitate can inhibit LPS (HY-D1056)-induced Kupffer cells and rat peritoneal macrophages. Methyl palmitate is able to inhibit the phagocytic function of RAW cells. Methyl palmitate is antagonistic to muscarinic receptors. Methyl palmitate exerts cardioprotective effects against ischemia/reperfusion injury in vivo. Methyl palmitate is highly toxic against adult T. cinnabarinus.

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Methyl palmitate 화학구조

CAS No. : 112-39-0

사이즈	재고	수량
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid or liquid
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	견적 받기
50 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Methyl palmitate:

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

Methyl palmitate (Compound MP) (0.25-1 mM, 24 h) reduces the phagocytic activity and nitrite production dose-dependently in RAW cells^[1].
Methyl palmitate (75 μM) significantly reduces the I/R-decreased cell viability in cardiomyocytes and increases the level of p-AKT^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	RAW cells
Concentration:	0.5 mM
Incubation Time:	24 h
Result:	Significantly decreased TNF-α release and inhibited the expression of NF-κB.

In Vivo

Methyl palmitate (Compound MP) (75-150 mg/kg, i.p., single dose) significantly reduces Carrageenan (HY-125474)-induced paw edema in Wistar rats^[4].
Methyl palmitate (150 mg/kg, i.p., single dose) significantly inhibits IL-6 and TNF-α in Wistar rats^[4].
Methyl palmitate (300 mg/kg, i.v., 5 min before reperfusion) attenuates the I/R-induced myocardium infarct size and significantly reduces the level of CK-MB in I/R-injured heart cardiomyocytes of rat model^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

270.45

화학식

C₁₇H₃₄O₂

CAS No.

112-39-0

Appearance

<32°C Solid,>35°C Liquid

Color

Colorless to off-white

SMILES

CCCCCCCCCCCCCCCC(OC)=O

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (184.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (184.88 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6975 mL	18.4877 mL	36.9754 mL
5 mM	0.7395 mL	3.6975 mL	7.3951 mL
10 mM	0.3698 mL	1.8488 mL	3.6975 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (9.24 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 30 mg/mL (110.93 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 98.0%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (238 KB) HNMR (239 KB)

Handling Instructions (2659 KB)

References

[1]. El-Demerdash E, et al, Anti-inflammatory and antifibrotic effects of methyl palmitate. Toxicol Appl Pharmacol. 2011 Aug 1;254(3):238-44. [Content Brief]

[2]. N. R. Di Luzio, et al. Depression of phagocytic activity and immune response by methyl palmitate. Am J Physiol. 1964 May;206:939-43. [Content Brief]

[3]. Y. N. Wang, et al. Methyl Palmitate, an Acaricidal Compound Occurring in Green Walnut Husks. Journal of Economic Entomology, Volume 102, Issue 1, 1 February 2009, Pages 196–202.

[4]. Saeed, N. M., et al., (2012). Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models. Toxicology and applied pharmacology, 264(1), 84–93. [Content Brief]

[5]. Shen, Y. J., et al., (2021). Methyl palmitate protects heart against ischemia/reperfusion-induced injury through G-protein coupled receptor 40-mediated activation of the PI3K/AKT pathway. European journal of pharmacology, 905, 174183. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol	1 mM	3.6975 mL	18.4877 mL	36.9754 mL	92.4385 mL
	5 mM	0.7395 mL	3.6975 mL	7.3951 mL	18.4877 mL
	10 mM	0.3698 mL	1.8488 mL	3.6975 mL	9.2439 mL
	15 mM	0.2465 mL	1.2325 mL	2.4650 mL	6.1626 mL
	20 mM	0.1849 mL	0.9244 mL	1.8488 mL	4.6219 mL
	25 mM	0.1479 mL	0.7395 mL	1.4790 mL	3.6975 mL
	30 mM	0.1233 mL	0.6163 mL	1.2325 mL	3.0813 mL
	40 mM	0.0924 mL	0.4622 mL	0.9244 mL	2.3110 mL
	50 mM	0.0740 mL	0.3698 mL	0.7395 mL	1.8488 mL
	60 mM	0.0616 mL	0.3081 mL	0.6163 mL	1.5406 mL
	80 mM	0.0462 mL	0.2311 mL	0.4622 mL	1.1555 mL
	100 mM	0.0370 mL	0.1849 mL	0.3698 mL	0.9244 mL