2. Metabolic Enzyme/Protease Anti-infection
  3. Cytochrome P450 Fungal Bacterial
  4. Rhapontigenin

Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC50  = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively.

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CAS 番号 : 500-65-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 144 在庫あり
Solution
10 mM * 1 mL in DMSO USD 144 在庫あり
Solid
1 mg $62 在庫あり
5 mg $131 在庫あり
10 mg $222 在庫あり
20 mg $377 在庫あり
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カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Other Forms of Rhapontigenin:

Rhapontigenin 関連抗体

Top Publications Citing Use of Products

    Rhapontigenin purchased from MedChemExpress. Usage Cited in: FASEB J. 2024 Nov 30;38(22):e70205.  [Abstract]

    Lung tissue H&E staining treated with Rhapontigenin (Rhap) (10 mg/kg, i.p.).

    Rhapontigenin purchased from MedChemExpress. Usage Cited in: Nat Biomed Eng. 2022 Jan;6(1):76-93.  [Abstract]

    Effects of Kaem and Rhapontigenin (Rhap) (20, 40, 80 μM) on the protein levels of mitofusin2 (MFN2), YFP-Parkin and Tim23 in HeLa cells stably overexpressing YFP-Parkin.

    Rhapontigenin purchased from MedChemExpress. Usage Cited in: Nat Biomed Eng. 2022 Jan;6(1):76-93.  [Abstract]

    Images showing co-localization of mitochondria (Mito-GFP) and lysosomes (LAMP1 antibody) under Kaem and Rhapontigenin (Rhap) (20 uM, 24 h) administration in GFP-mito-mCherry-Parkin HeLa cells.

    Rhapontigenin purchased from MedChemExpress. Usage Cited in: Nat Biomed Eng. 2022 Jan;6(1):76-93.  [Abstract]

    Effects of Kaem and Rhapontigenin (Rhap) (0.2 mM) on designated gene expression in day 1 adult worms.

    Rhapontigenin purchased from MedChemExpress. Usage Cited in: Nat Biomed Eng. 2022 Jan;6(1):76-93.  [Abstract]

    Immunohistochemical analysis of Aβ load in 3xTg AD mice hippocampi and cortices under Kaem or Rhapontigenin (Rhap) (100 mg/kg, p.o.) treatment.

    Cytochrome P450 アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC50  = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively[1].

    IC50 & Target[1]

    CYP1A1

    400 nM (IC50)

    Cellular Effect
    Cell Line Type Value Description References
    HL-60 IC50
    48 μM
    Compound: 10a
    In vitro inhibitory concentration against proliferation of HL60 cells
    In vitro inhibitory concentration against proliferation of HL60 cells
    		[PMID: 12877593]
    J774 IC50
    102.8 μM
    Compound: 6
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 29726680]
    J774 IC50
    19.4 μM
    Compound: 6
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA
    		[PMID: 29726680]
    J774 IC50
    99.1 μM
    Compound: 6
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA
    		[PMID: 29726680]
    体外実験

    Rhapontigenin (0-250 μM; 24 hours) demonstrates concentration-dependent?anti-cancer?activity with an IC50 115μM in HEP G2 cells[1].
    ? Rhapontigenin (20 μM; 20 hours) pre-treatment decreases TGF-β triggered increased snail expression in diverse cancer cells[2].
    ? Rhapontigenin (0-20 μM; 6 hours) inhibits TGF-β-induced expression of N-cadherin, vimentin, and CA9 in a dose-dependent manner[2].
    ? Rhapontigenin inhibits ADP- and collagen-induced platelet aggregation with IC50 values of 4 and 70 μg/ml, respectively[3].
    ? Rhapontigenin demonstrates a strong inhibitory activity on the 13-hexosaminidase release induced by DNP-BSA, it exhibits IC50 value of 0.03 mM in RBL 2H3 cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Rhapontigenin 関連抗体

    Western Blot Analysis[2]

    Cell Line: HeLa, A549,769-P cells
    Concentration: 0 μM; 2.5 μM; 5 μM; 10 μM; 20 μM
    Incubation Time: 6 hours
    Result: Induced ubiquitination and degradation of HIF-1α.
    体内実験

    Rhapontigenin (intraperitoneal injection; 25mg/kg) shows significant protection from death due to pulmonary thrombosis in mice, those samples are orally administered 90 min before tail vein injection of epinephrine and collagen[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: ICR mice[3]
    Dosage: 25mg/kg
    Administration: 25mg/kg; intraperitoneal injection
    Result: Showed anti-thrombosis activity with 60% protection.
    分子量

    258.27

    分子式

    C15H14O4
    CAS 番号
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    OC1=CC(/C=C/C2=CC=C(OC)C(O)=C2)=CC(O)=C1
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    DMSO : 125 mg/mL (483.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.8719 mL 19.3596 mL 38.7192 mL
    5 mM 0.7744 mL 3.8719 mL 7.7438 mL
    10 mM 0.3872 mL 1.9360 mL 3.8719 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    体積 （開始）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (8.05 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (8.05 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.66%

    COA (246 KB) HNMR (198 KB) RP-HPLC (102 KB) MS (113 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.8719 mL 19.3596 mL 38.7192 mL 96.7979 mL
    5 mM 0.7744 mL 3.8719 mL 7.7438 mL 19.3596 mL
    10 mM 0.3872 mL 1.9360 mL 3.8719 mL 9.6798 mL
    15 mM 0.2581 mL 1.2906 mL 2.5813 mL 6.4532 mL
    20 mM 0.1936 mL 0.9680 mL 1.9360 mL 4.8399 mL
    25 mM 0.1549 mL 0.7744 mL 1.5488 mL 3.8719 mL
    30 mM 0.1291 mL 0.6453 mL 1.2906 mL 3.2266 mL
    40 mM 0.0968 mL 0.4840 mL 0.9680 mL 2.4199 mL
    50 mM 0.0774 mL 0.3872 mL 0.7744 mL 1.9360 mL
    60 mM 0.0645 mL 0.3227 mL 0.6453 mL 1.6133 mL
    80 mM 0.0484 mL 0.2420 mL 0.4840 mL 1.2100 mL
    100 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.9680 mL
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    Rhapontigenin Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Rhapontigenin500-65-2Cytochrome P450FungalBacterialCYPsantiallergicanticoagulativehypoglycemicantiangiogenicpurgativeInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-N2229
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