Levamisole (Synonyms: (-)-Tetramisole)

Name: Levamisole
Brand: MedChemExpress
SKU: HY-A0106
Rating: 5.0 (14 reviews)

Art. -Nr.: HY-A0106 Reinheit: 99.96%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC₅₀=300 μM) and α3β4 (EC₅₀=100 μM) subtype of nAChRs. Orally active.

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Levamisole Chemische Struktur

CAS. Nr. : 14769-73-4

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
100 mg	Auf Lager	Estimated Time of Arrival: December 31
500 mg	Auf Lager	Estimated Time of Arrival: December 31
1 g	Auf Lager	Estimated Time of Arrival: December 31
5 g	Auf Lager	Estimated Time of Arrival: December 31
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50 g	Angebot einholen

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This product is a controlled substance and not for sale in your territory.

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Based on 14 publication(s) in Google Scholar

Other Forms of Levamisole:

Tetramisole hydrochloride In-stock
Levamisole hydrochloride In-stock
Dexamisole Angebot einholen
Tetramisole Angebot einholen
Levamisole (Standard) Angebot einholen

14 Publications Citing Use of MCE Levamisole

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Parasite Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 100 μM Compound: Levamisole	Cytotoxicity against human A549 cells assessed as cell growth inhibition after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell growth inhibition after 24 hrs by MTT assay	[PMID: 27376493]
CCRF-CEM	IC₅₀	> 250 μM Compound: Levamisole	Cytotoxicity against human CEM cells after 72 hrs by Coulter counting method Cytotoxicity against human CEM cells after 72 hrs by Coulter counting method	[PMID: 25064346]
HeLa	IC₅₀	250 μM Compound: Levamisole	Cytotoxicity against human HeLa cells after 72 hrs by Coulter counting method Cytotoxicity against human HeLa cells after 72 hrs by Coulter counting method	[PMID: 25064346]
HeLa	IC₅₀	96 μM Compound: Levamisole	Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 24 hrs by MTT assay	[PMID: 27376493]
L1210	IC₅₀	206 μM Compound: Levamisole	Cytotoxicity against mouse L1210 cells after 48 hrs by Coulter counting method Cytotoxicity against mouse L1210 cells after 48 hrs by Coulter counting method	[PMID: 25064346]
MCF7	IC₅₀	> 100 μM Compound: Levamisole	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 24 hrs by MTT assay	[PMID: 27376493]

In Vivo

(S)-(-)-Levamisole (Levamisole) (50 μg/ml and 200 μg/ml; p.o.; 30 days) prevents weight gain in mice that were fed a high fat diet^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Klinische Studie

Molekulargewicht

204.30

Formel

C₁₁H₁₂N₂S

CAS. Nr.

14769-73-4

Appearance

Solid

Color

White to off-white

SMILES

C12=N[C@@H](C3=CC=CC=C3)CN1CCS2

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (489.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8948 mL	24.4741 mL	48.9481 mL
5 mM	0.9790 mL	4.8948 mL	9.7896 mL
10 mM	0.4895 mL	2.4474 mL	4.8948 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (12.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (12.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Purity: 99.97%

Select Batch:

Data Sheet (275 KB) SDS (396 KB)

COA (249 KB) HNMR (120 KB) RP-HPLC (86 KB) LCMS (329 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Lewis JA, et al. Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet. Curr Pharm Des. 2017;23(12):1869-1872. [Content Brief]

[2]. Mehta KP, et al. Immunoregulatory treatment for minimal change nephrotic syndrome. Arch Dis Child. 1986;61(2):153-158. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.8948 mL	24.4741 mL	48.9481 mL	122.3703 mL
	5 mM	0.9790 mL	4.8948 mL	9.7896 mL	24.4741 mL
	10 mM	0.4895 mL	2.4474 mL	4.8948 mL	12.2370 mL
	15 mM	0.3263 mL	1.6316 mL	3.2632 mL	8.1580 mL
	20 mM	0.2447 mL	1.2237 mL	2.4474 mL	6.1185 mL
	25 mM	0.1958 mL	0.9790 mL	1.9579 mL	4.8948 mL
	30 mM	0.1632 mL	0.8158 mL	1.6316 mL	4.0790 mL
	40 mM	0.1224 mL	0.6119 mL	1.2237 mL	3.0593 mL
	50 mM	0.0979 mL	0.4895 mL	0.9790 mL	2.4474 mL
	60 mM	0.0816 mL	0.4079 mL	0.8158 mL	2.0395 mL
	80 mM	0.0612 mL	0.3059 mL	0.6119 mL	1.5296 mL
	100 mM	0.0489 mL	0.2447 mL	0.4895 mL	1.2237 mL

Levamisole Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levamisole14769-73-4(-)-TetramisolenAChRParasiteNicotinic acetylcholine receptorsimmunomodulatorypositive allosteric modulatorCD-1 Mice,α3β2 nAChRInhibitorinhibitorinhibit

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Levamisole (Synonyms: (-)-Tetramisole)

Kundenbewertung

Other Forms of Levamisole:

Levamisole Related Antibodies

14 Publications Citing Use of MCE Levamisole

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Parasite Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

Levamisole Related Classifications

Keywords:

Ihre kürzlich angesehenen Produkte:

Kundenbewertung

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SAFETY DATA SHEET (SDS)

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