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Results for "

β-agonists

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (1) Adrenergic Receptor (5) AMPK (1) Androgen Receptor (1) Apoptosis (1) ATP-binding cassette (ABC) transporters (1) Autophagy (1) Drug Derivative (1) Endogenous Metabolite (8) Estrogen Receptor/ERR (22) IKK (1) Interleukin Related (1) Isotope-Labeled Compounds (4) LDLR (1) LXR (7) Mitochondrial Metabolism (1) Phosphatase (1) Phospholipase (1) PPAR (1) RAR/RXR (3) Reference Standards (6) REV-ERB (2) Smo (1) Thyroid Hormone Receptor (35) Wnt (1)
By Research Areas:	Cancer (29) Cardiovascular Disease (5) Endocrinology (20) Infection (3) Inflammation/Immunology (13) Metabolic Disease (27) Neurological Disease (11)

By Targets:

Acetyl-CoA Carboxylase (1)

Adrenergic Receptor (5)

AMPK (1)

Androgen Receptor (1)

Apoptosis (1)

ATP-binding cassette (ABC) transporters (1)

Autophagy (1)

Drug Derivative (1)

Endogenous Metabolite (8)

Estrogen Receptor/ERR (22)

IKK (1)

Interleukin Related (1)

Isotope-Labeled Compounds (4)

LDLR (1)

LXR (7)

Mitochondrial Metabolism (1)

Phosphatase (1)

Phospholipase (1)

PPAR (1)

RAR/RXR (3)

Reference Standards (6)

REV-ERB (2)

Smo (1)

Thyroid Hormone Receptor (35)

Wnt (1)

By Research Areas:

Cancer (29)

Cardiovascular Disease (5)

Endocrinology (20)

Infection (3)

Inflammation/Immunology (13)

Metabolic Disease (27)

Neurological Disease (11)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12216

Resmetirom 20+ Cited Publications MGL-3196; VIA-3196	Thyroid Hormone Receptor	Cardiovascular Disease Endocrinology
Resmetirom (MGL-3196) is a highly selective and orally active thyroid hormone receptor β (THR-β) agonist with an EC₅₀ value of 0.21 μM. Resmetirom can be used for the study of noncirrhotic nonalcoholic steatohepatitis .

HY-16989

SR9009 35+ Cited Publications	Autophagy	Cancer
SR9009 is a REV-ERBα/β agonist with IC₅₀s of 670 nM and 800 nM for REV-ERBα and REV-ERBβ, respectively.

HY-A0070

Liothyronine sodium Maximum Cited Publications 39 Publications Verification Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-N0377

Liquiritigenin 10+ Cited Publications 4',7-Dihydroxyflavanone	Estrogen Receptor/ERR	Neurological Disease Inflammation/Immunology Cancer
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC₅₀ of 36.5 nM for activation of the ERE tk-Luc.

HY-10629

LXR-623 10+ Cited Publications WAY 252623	LXR	Metabolic Disease Cancer
LXR-623 is a brain-penetrant partial LXRα and full LXRβ agonist, with IC₅₀s of 24 nM and 179 nM, respectively.

HY-111288

MB-07811 VK-2809	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist . MB-07811 has cholesterol and triglycerides lowering activity .

HY-18295

Erteberel 2 Publications Verification LY500307	Estrogen Receptor/ERR	Neurological Disease Cancer
Erteberel (LY500307) is a potent and selective estrogen receptor beta (ERβ) agonist with K_i and EC₅₀ of 1.54 nM and 3.61 nM, respectively. Erteberel has anti-tumor activities .

HY-B0412

Estriol 5 Publications Verification Oestriol	Estrogen Receptor/ERR Endogenous Metabolite	Cancer
Estriol (Oestriol), an orally active estrogen, is a ERα and ERβ agonist. Estriol is a potent GPR30 antagonist in estrogen receptor-negative breast cancer cells. Estriol can ameliorate disease severity through immunomodulatory mechanisms that decrease tissue inflammation. Estriol has powerful proconvulsant effects .

HY-A0070B

Liothyronine sodium hydrate Maximum Cited Publications 39 Publications Verification Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-15483

DY131 3 Publications Verification GSK 9089	Estrogen Receptor/ERR Smo	Endocrinology Cancer
DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ . DY131 also inhibits Smo signaling .

HY-A0070AR

Liothyronine (Standard) 30+ Cited Publications Triiodothyronine (Standard); 3,3',5-Triiodo-L-thyronine (Standard); T3 (Standard)	Thyroid Hormone Receptor Endogenous Metabolite Reference Standards	Endocrinology Cancer
Liothyronine (Standard) is the analytical standard of Liothyronine. This product is intended for research and analytical applications. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070AG

Liothyronine 1 Publications Verification Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor	Endocrinology Cancer
Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-14933

Prinaberel 3 Publications Verification ERB-041	Estrogen Receptor/ERR Wnt Apoptosis	Cancer
Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC₅₀s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis .

HY-16988

SR9011 5+ Cited Publications	REV-ERB	Cancer
SR9011 is a REV-ERBα/β agonist with IC₅₀s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.

HY-100608

BMS453 1 Publications Verification BMS-189453	RAR/RXR	Cancer
BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ .

HY-101271

WAY-200070 1 Publications Verification	Estrogen Receptor/ERR	Neurological Disease
WAY-200070 is a selective estrogen receptor β (ERβ) agonist with an IC₅₀ of 2.3 nM.

HY-143613

*THR-β agonist* 2**	Thyroid Hormone Receptor	Metabolic Disease
THR-β agonist 2 is a potent agonist of THR-β. THR-β agonist 2 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021121210A1, compound 3) .

HY-168046

ALG-055009	Thyroid Hormone Receptor	Metabolic Disease
ALG-055009 is a selective and orally active Thyroid Hormone Receptor Beta (THR-β) agonist with an EC₅₀ of 0.063 μM. ALG-055009 binds to the T3 hormone pocket of human THR-β, forming polar interactions with protein residues. ALG-055009 can lower total cholesterol levels in rats on a high-fat diet. ALG-055009 exhibits high metabolic stability, good permeability, a long in vivo half-life, and limited drug-drug interaction liability. ALG-055009 can be used in studies related to metabolic dysfunction-associated fatty liver disease .

HY-16988A

SR9011 hydrochloride 5+ Cited Publications	REV-ERB	Cancer
SR9011 hydrochloride is a REV-ERBα/β agonist with IC₅₀s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.

HY-160207

Elunetirom MA-JD21; ABX-002	Thyroid Hormone Receptor	Neurological Disease
Elunetirom (MA-JD21 )is a TR-β selective CNS-penetrant *TR-β* agonist prodrug and can be used for study of major depressive disorder (MDD) .

HY-119518

BMS641 BMS-209641	RAR/RXR	Cancer
BMS641 (BMS-209641) is a selective RARβ agonist. BMS641 has a higher affinity for RARβ (K_d, 2.5 nM) that is 100 times higher than that for RARα (K_d, 225 nM) or RARγ (K_d, 223 nM) .

HY-19383

Ertiprotafib 2 Publications Verification PTP 112	Phosphatase IKK PPAR	Metabolic Disease
Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC₅₀ of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC₅₀ of ~1 μM for PPARα/PPARβ.

HY-110157

AC-186	Estrogen Receptor/ERR	Neurological Disease
AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC₅₀s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender selective neuroprotective effects in a male rat model of Parkinson's disease .

HY-123402

GSK3987 2 Publications Verification	LXR	Metabolic Disease
GSK3987 is a pan LXRα/β agonist with EC₅₀s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation .

HY-147055

*THR-β agonist* 5**	Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
THR-β agonist 5 is a *THR-β* agonist. THR-β agonist 5 can be used for the research of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis .

HY-100469

*LXRβ agonist-2*	LXR	Inflammation/Immunology
LXRβ agonist-2 is an orally active and selective LXRβ agonist. LXRβ agonist-2 increases high-density lipoprotein cholesterol levels without elevating plasma triglyceride levels. LXRβ agonist-2 decreases lipid accumulation area in the aortic arch. LXRβ agonist-2 can be used for the research of atherosclerosis .

HY-146997

*TRβ agonist* 1**	Thyroid Hormone Receptor	Metabolic Disease
TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC₅₀ value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH) .

HY-19513

MB-07344	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a K_i of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys .

HY-A0070R

Liothyronine sodium (Standard) Triiodothyronine sodium (Standard); 3,3',5-Triiodo-L-thyronine sodium (Standard); T3 sodium (Standard)	Reference Standards Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine (sodium) (Standard) is the analytical standard of Liothyronine (sodium). This product is intended for research and analytical applications. Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-163945

ZTA-261	Thyroid Hormone Receptor	Metabolic Disease
ZTA-261 is a highly selective and low toxic thyroid hormone receptor β subtype (THR-β) agonist (IC₅₀=6.3 nM) that reduces body weight and visceral fat through a liothyronine (HY-A0070A) mediated pathway. ZTA-261 can be used in the study of lipid metabolism and obesity prevalence .

HY-A0070AS1

Liothyronine-13C9,15N Triiodothyronine-¹³C₉,¹⁵N; 3,3',5-Triiodo-L-thyronine-¹³C₉,¹⁵N; T3-¹³C₉,¹⁵N	Thyroid Hormone Receptor Endogenous Metabolite	Cancer
Liothyronine- ¹³C₉, ¹⁵N is the ¹³C and ¹⁵N labeled Liothyronine . Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-D1734

FITC-GW3965	LXR	Cardiovascular Disease
FITC-GW3965 is a fluorescence-labelled liver X receptor β (LXRβ) agonist GW3965 (HY-10627). FITC-GW3965 is a tracer, that can be designed by replacing the trifluoromethyl of GW3965 with an amide to link the FITC. FITC-GW3965 can be used to study the function of LXRβ .

HY-172661

Kylo-0603	Thyroid Hormone Receptor Interleukin Related LDLR	Infection Metabolic Disease
KYLO-0603 is an orally active, selective THR-β agonist (EC₅₀ : 31.07 nM). KYLO-0603 has significant activity in lowering serum cholesterol and low-density lipoprotein cholesterol. KYLO-0603 upregulates the expression of THR-regulated genes (including iodothyronine deiodinase 1 (Dio1), malic enzyme 1 (Me1), and thyroid hormone response (Thrsp) gene) and inhibits the expression of inflammatory and fibrotic genes (low-density lipoprotein receptor (LDL-R) gene) by activating THR-β receptors. KYLO-0603 can be used to treat metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis research .

HY-176525

PLC-β-IN-1	Phospholipase	Inflammation/Immunology
PLC-β-IN-1 (Compound 8a) is a PLCβ inhibitor. PLC-β-IN-1 exerts anti-airway contraction activity by inhibiting PLCβ and its downstream signaling pathways, and can enhance the airway relaxation effect of β-agonists. PLC-β-IN-1 can be used in the study of asthma .

HY-178015

*THR-β agonist* 11**	Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. THR-β agonist 11 shows potent cholesterol-lowering activity in cholesterol-fed rats. THR-β agonist 11 significantly reduces serum total TG, LDL-cholesterol, liver total TC and TG levels, and alleviates hepatic steatosis, inflammation and fibrosis in HFD-CCl4-induced Metabolic dysfunction-associated steatohepatitis (MASH) model mice. THR-β agonist 11 can be used for the study of metabolic dysfunction-associated steatohepatitis (MASH) and other fibrotic diseases .

HY-149584

CIDD-0149897	Estrogen Receptor/ERR	Cancer
CIDD-0149897 is a potent, selective and brain-penetrant ERβ agonist. CIDD-0149897 exert antitumor functions in glioblastoma .

HY-W702027

Deterenol hydrochloride AL842	Adrenergic Receptor	Cardiovascular Disease
Deterenol hydrochloride (AL842) is a selective beta-agonist. Deterenol hydrochloride causes vasodepressor, anxiety, increasing heart rate, hypotension palpitation and respiratory distress .

HY-151230

(-)-Erteberel	Estrogen Receptor/ERR	Cancer
(-)-Erteberel is a selective estrogen receptor beta (ERβ) agonist. (-)-Erteberel can be utilized in the study of diseases mediated by estrogen receptor beta (ERβ), such as prostate cancer .

HY-A0070C

Liothyronine hydrochloride Triiodothyronine hydrochloride; 3,3',5-Triiodo-L-thyronine hydrochloride; T3 hydrochloride	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-19513A

MB-07344 sodium	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
MB-07344 sodium is a potent thyroid hormone receptor (TR)-β agonist with a K_i of 2.17 nM. MB-07344 sodium has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys .

HY-A0070AS2

Liothyronine-13C6-1 Triiodothyronine-¹³C₆-1; 3,3',5-Triiodo-L-thyronine-¹³C₆-1; T3-¹³C₆-1	Thyroid Hormone Receptor	Endocrinology Cancer
Liothyronine- ¹³C₆-1 is a ¹³C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070AS3

Liothyronine-d3 Triiodothyronine-d₃; 3,3',5-Triiodo-L-thyronine-d₃; T3-d₃	Endogenous Metabolite Thyroid Hormone Receptor Isotope-Labeled Compounds	Endocrinology Cancer
Liothyronine-d₃ is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-117167

KB-141	Thyroid Hormone Receptor	Cancer
KB-141 is a potent and selective TRβ agonist. The IC₅₀ values are 23.9 nM and 3.3 nM for binding affinities from displacement of T3 from hTRα1 and hTRβ1, respectively. KB-141 has anti-obesity, anti-diabetic, and lipid-lowering effects?and can be used as an anti-cholesteremic agent in vivo .

HY-131105

Cimbuterol	Adrenergic Receptor	Metabolic Disease Endocrinology
Cimbuterol is a β-adrenergic agonist. β-adrenergic agonists act as bronchodilators and tocolytics. β-adrenergic agonists promote growth .

HY-146275

*LXRβ agonist-3*	LXR	Cancer
LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC₅₀ of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC₅₀ of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma .

HY-149218

*THR-β agonist* 6**	Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC₅₀s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research .

HY-147501

*TRβ agonist* 3**	Thyroid Hormone Receptor	Metabolic Disease
TRβ agonist 3 (Compound 3) is a potent agonist of TRβ. TRβ agonist 3 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 3 is a new potential TRβ-selective thyromimetics .

HY-147500

*TRβ agonist* 2**	Thyroid Hormone Receptor	Metabolic Disease
TRβ agonist 2 (Compound 1) is a potent agonist of TRβ. TRβ agonist 2 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 2 is a new potential TRβ-selective thyromimetics .

HY-175676

*THR-β agonist* 10**	Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
THR-β agonist 10 is an orally active and selective *THR-β* agonist, with an EC₅₀ of 11 nM. THR-β agonist 10 significantly reduces ALT (Alanine Aminotransferase), TC (Total Cholesterol), and LDL-C (Low-Density Lipoprotein Cholesterol) levels, and improves steatosis, ballooning, inflammation and fibrosis in the metabolic dysfunction-associated steatohepatitis (MASH) mouse model. THR-β agonist 10 can be used for the study of MASH .

HY-19468

ERB-196 WAY-202196	Estrogen Receptor/ERR	Neurological Disease Inflammation/Immunology
ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.

Cat. No.	Product Name

HY-L218

Animal Drug Library

167 compounds

Animal drug (also veterinary drug) refers to a drug intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease in animals. Animal Drugs @ FDA is a searchable online database that includes most FDA-approved and conditionally approved animal drugs. The major classes of veterinary drugs include antibiotics, anthelmintics, coccidiostats, nonsteroidal anti-inflammatory drugs, sedatives, corticosteroids, beta-agonists, and anabolic hormones.

MCE has collected 167 FDA-approved veterinary drug compounds for use in scientific research.

Cat. No.	Product Name	Type

HY-A0070AG

Liothyronine 1 Publications Verification Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Fluorescent Dyes
Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-D1734

FITC-GW3965	Fluorescent Dyes
FITC-GW3965 is a fluorescence-labelled liver X receptor β (LXRβ) agonist GW3965 (HY-10627). FITC-GW3965 is a tracer, that can be designed by replacing the trifluoromethyl of GW3965 with an amide to link the FITC. FITC-GW3965 can be used to study the function of LXRβ .

Cat. No.	Product Name	Type

HY-A0070AG

Liothyronine 1 Publications Verification Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Biochemical Assay Reagents
Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0070

Liothyronine sodium Maximum Cited Publications 39 Publications Verification Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium	Monophenols Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-N0377

Liquiritigenin 10+ Cited Publications 4',7-Dihydroxyflavanone	Neurological Disease Classification of Application Fields Plants Flavonoids Microorganisms Leguminosae Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch. Source Classification	Estrogen Receptor/ERR
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC₅₀ of 36.5 nM for activation of the ERE tk-Luc.

HY-B0412

Estriol 5 Publications Verification Oestriol	Monophenols Immune System Disorder Classification of Application Fields Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer Source Classification	Estrogen Receptor/ERR Endogenous Metabolite
Estriol (Oestriol), an orally active estrogen, is a ERα and ERβ agonist. Estriol is a potent GPR30 antagonist in estrogen receptor-negative breast cancer cells. Estriol can ameliorate disease severity through immunomodulatory mechanisms that decrease tissue inflammation. Estriol has powerful proconvulsant effects .

HY-A0070B

Liothyronine sodium hydrate Maximum Cited Publications 39 Publications Verification Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate	Monophenols Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070AR

Liothyronine (Standard) 30+ Cited Publications Triiodothyronine (Standard); 3,3',5-Triiodo-L-thyronine (Standard); T3 (Standard)	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Thyroid Hormone Receptor Endogenous Metabolite Reference Standards
Liothyronine (Standard) is the analytical standard of Liothyronine. This product is intended for research and analytical applications. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070R

Liothyronine sodium (Standard) Triiodothyronine sodium (Standard); 3,3',5-Triiodo-L-thyronine sodium (Standard); T3 sodium (Standard)	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Reference Standards Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine (sodium) (Standard) is the analytical standard of Liothyronine (sodium). This product is intended for research and analytical applications. Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070C

Liothyronine hydrochloride Triiodothyronine hydrochloride; 3,3',5-Triiodo-L-thyronine hydrochloride; T3 hydrochloride	Monophenols Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-N15473

Isopaucifloral F (±)-Isopaucifloral F	Phenols Polyphenols Plants Dipterocarpaceae Vatica pauciflora (Korth.) Blume Source Classification	Estrogen Receptor/ERR Drug Derivative
Isopaucifloral F ((±)-Isopaucifloral F) is a Resveratrol (HY-16561)-derived sesquiterpenes. Isopaucifloral F is an orally active ERβ agonist (EC₅₀: 46.96 μM). Isopaucifloral F has antiosteoporosis activity. LD₅₀ in rats: > 5 mg/kg .

Cat. No.	Product Name	Chemical Structure

HY-A0070AS1

Liothyronine-13C9,15N
Liothyronine- ¹³C₉, ¹⁵N is the ¹³C and ¹⁵N labeled Liothyronine . Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070AS2

Liothyronine-13C6-1
Liothyronine- ¹³C₆-1 is a ¹³C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-A0070AS3

Liothyronine-d3
Liothyronine-d₃ is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-160266

*THR-β agonist* 7**
THR-β agonist-1 (Example 2) is a *THR-β* agonist, with EC₅₀ values of 52 nM and 1017 nM for THR-β and THR-α, respectively .

HY-163712S

17-Epiestriol-d5-1

17-Epiestriol-d₅-1 is the deuterium labeled 17-Epiestriol (HY-163712). 17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase .

HY-W742012

Clencyclohexerol-d10
Clencyclohexerol-d₁₀ is the deuterium-labeled Clencyclohexerol (HY-117406). Clencyclohexerol-d₁₀ is a *β-agonist*. Clencyclohexerol-d₁₀ can be used as a growth promoter in animals .

HY-N0377S

Liquiritigenin-d4
Liquiritigenin-d₄ (4',7-Dihydroxyflavanone-d₄) is the deuterium labeled Liquiritigenin (HY-N0377). Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC₅₀ of 36.5 nM for activation of the ERE tk-Luc.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0070AG

Liothyronine 1 Publications Verification Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor	Endocrinology Cancer
Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

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