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  2. Estrogen Receptor/ERR
  3. ERB-196

ERB-196 (Synonyms: WAY-202196)

Cat. No.: HY-19468
Handling Instructions

ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.

For research use only. We do not sell to patients.

ERB-196 Chemical Structure

ERB-196 Chemical Structure

CAS No. : 550997-55-2

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10 mg USD 3366 Get quote

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ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.

IC50 & Target


In Vivo

ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist. ERB-196 significantly reduces histopathologic evidence of injury to the gastrointestinal mucosal surface (0.7±0.1 vs. 2.3±0.2 for control; p<0.05). The mucosal mass of 10-cm segments of small bowel mucosa shows better preservation of mucosal mass than control treatment (63±20 [ERB-196] vs. 31±24 [control]), but this difference fails to reach statistical significance (p<0.06). The administration of ERB-196 is highly effective in the prevention of lethality. Consistent with the neutropenic rat model, ERB-196 significantly increases survival when compare with vehicle control[1].


Please store the product under the recommended conditions in the Certificate of Analysis.

Animal Administration

The neutropenic rat model of pseudomonas sepsis are used in this study. For the survival study, ERB-196 (50 mg/kg; n=12) or vehicle control (n=8) is administered daily by orogastric feeding beginning on day 4 after the first dose of cyclophosphamide and continuing for 8 days. Animals are assessed clinically and pathologically by measuring daily body weight, body temperature, presence of bacteremia, circulating endotoxin levels, and pathologic evidence of damage to the gastrointestinal epithelium and liver by light microscopy and electron microscopy. Blood and tissue samples are serially diluted in sterile saline and incubated at 37°C on pseudomonas agar for quantitative assessment of bacterial concentrations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-19468