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  3. MB-07811

MB-07811 (Synonyms: VK-2809)

Cat. No.: HY-111288
Handling Instructions

MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist. MB-07811 has cholesterol and triglycerides lowering activity.

For research use only. We do not sell to patients.

MB-07811 Chemical Structure

MB-07811 Chemical Structure

CAS No. : 852948-13-1

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Description

MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist[1]. MB-07811 has cholesterol and triglycerides lowering activity[2].

IC50 & Target

Thyroid hormone receptor-β[2]

In Vitro

MB-07811 (VK-2809) is potential for liver targeting with a low affinity for thyroid hormone receptors (TRβ Ki=14.6 ± 0.5 μM; TRα Ki=12.5 ± 0.6 μM)[2].

In Vivo

MB-07811 (VK-2809) (0.3-30 mg/kg; orally once daily for 14 days) reduces cholesterol and triglycerides in diet-induced obese mice[2].

Animal Model: 4-week-old male C57BL/6 mice (diet-induced obese (DIO) mice)[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Orally once daily; 14 days
Result: Reduced total plasma cholesterol, and reduced plasma triglycerides (40%) at the highest doses.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

514.98

Formula

C₂₈H₃₂ClO₅P

CAS No.

852948-13-1

SMILES

OC1=CC=C(CC2=C(C)C=C(OC[[email protected]]3(OCC[[email protected]@H](C4=CC=CC(Cl)=C4)O3)=O)C=C2C)C=C1C(C)C

Shipping

Room temperature in continental US; may vary elsewhere

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MB-07811
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MB-07811

Cat. No.: HY-111288